Today’s CT Scan Of Lung Nodules——Panicking,Resigned To Dying?

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Hooandtrue93
Posts: 18
Joined: Tue May 11, 2021 10:28 pm

Re: Today’s CT Scan Of Lung Nodules——Panicking,Resigned To Dying?

Postby Hooandtrue93 » Wed Aug 11, 2021 2:37 pm

This lab has a clinical trial for a vaccine to prevent cancer recurrence for gastrointestinal cancers but in some of their mice the vaccine was able to clear lung nodules too. Maybe reach out and explain your situation see if they can help you out?

I would also see if your doctor has any recommendations for any trials or other centers that could treat your situation that you are able to access?


https://research.jefferson.edu/labs/res ... atory.html
28 year old, son of 62 year old mom
Stage 3B Duodenal Adenocarcinoma.
7/13 lymph nodes positive
02/22/2021: Whipple Surgery
04/08/2021: Port Surgery. CtDNA test sample taken (positive)
04/13/2021: Folfox-6 begins for 6 months
07/16/2021: ctDNA cleared. Continue with 3 more months of adjuvant chemo
09/21/2021: Last cycle of adjuvant chemotherapy.

JMRWife
Posts: 99
Joined: Mon Oct 05, 2015 9:41 pm

Re: Today’s CT Scan Of Lung Nodules——Panicking,Resigned To Dying?

Postby JMRWife » Wed Aug 11, 2021 2:58 pm

I won't pretend I know what you are going through right now. But it's never a bad idea to take it one day at a time. One day, you can handle. It's manageable. Praying for you and looking for updates.
Age 58.
4/27/2021 - Dx obstructing "apple core" sigmoid tumor at 30cm. MMR proficient. 4/28: Diverting colostomy.
Neoadjuvant Folfox 5/18; CEA 107.
9/8: 9 rounds Folfox completed. CEA 2.1.
Pathology: COLON, SIGMOID: -- INVASIVE ADENOCARCINOMA, MOD DIFFERENTIATED Clinical stage IIA.

9/28/21 CAT scan: Tumor was 6.4 x 3.8 cm, now 2.6 x 4.5 cm.

10/4/21: Sigmoid colectomy. 36 lymph nodes removed, 0 cancerous. Stage T2N0M0.

roadrunner
Posts: 460
Joined: Sun Jan 12, 2020 8:46 pm

Re: Today’s CT Scan Of Lung Nodules——Panicking,Resigned To Dying?

Postby roadrunner » Wed Aug 11, 2021 3:27 pm

I am very sorry you got this news. I have seen at least some reports of complete response from regimens where FOLFIRI or FOLFOX is combined with another agent, and believe that such treatment (and less dramatic approaches even down to Xeloda monotherapy) can also extend survival with reasonable or even excellent QOL, which has intrinsic value and may also create time to identify other strategies for treatment. I believe that genomic testing of a metastasis may be necessary for an optimal therapeutic course, and wonder if you’ve discussed that with your team. It may also be possible to combine or “stage” chemotherapeutic or immunotherapy approaches with surgery, ablation, or brachytherapy in the absence of a complete response from those alone. I would discuss all options in these regards with my team, keeping an open mind as to second or third opinions, then consider alternative, experimental approaches if nothing seems promising in the conventional realm. But I think there are likely approaches that may yield productive results. I wish you the best of luck.
7/19: RC: Staged IIIA, T2N1M0
approx 4.25 cm, low/mid rectum, mod. well diff.; lung micronodule
8/19-10/19 4 rds.FOLFOX neoadjuvant, 3 w/Oxiplatin (reduced 70-75%)
neoadjuvant chemorad 11/19
4 rounds FOLFOX July-August 2020
ncCR 10/20; biopsies neg
TAE 11/20, tumor cells removed
Chest CT 3/30/21 growth in 2 nodules (3 and 5mm)
VATS 12/8/21 sub-pleural met 7mm.
SBRT nodule 1/22
6/20/22 TAE rectal polyp benign)
NED from 3/22 - 3/23
4 cycles FOLFIRI
LUL VATS lobectomy for radio resistant met 7/7/23

roadrunner
Posts: 460
Joined: Sun Jan 12, 2020 8:46 pm

Re: Today’s CT Scan Of Lung Nodules——Panicking,Resigned To Dying?

Postby roadrunner » Wed Aug 11, 2021 4:14 pm

Yeah, I am doing three month follow-up. I have two that may be problematic, was offered a choice to watch or resect. I chose to watch because of small size and because the scan that suggested growth was contrast after non-contrast (which can dramatically increase perceived size), and they appear stable. So far so good. But still in monitoring mode.

As far as waiting goes, I’d get recommendations from your team (and second opinions as necessary) that align with your goals. I was diving into this fairly deeply before the stable scan, but have given myself a break since (psychological breaks can be as important as chemo breaks!). In my case, if later scans show growth, I would go ahead with a resection as soon as the nodules appear big enough for genomic testing, to find, and to grab without unnecessary removal of healthy lung tissue.

It seems like your situation is more complex. If I understand it right, your doctors will likely recommend systemic therapy. I have no idea what the best options are there, and there may well be multiple choices, some potentially mutually exclusive. So I’d want to consider those options carefully. But since you asked, no, I wouldn’t wait just to wait if I were you. It seems from your report that these have declared themselves as disease. If it were me, I’d say it’s time to fight them. Just my perspective. Of course, your doctors will have an opinion there that is infinitely more valuable than mine. And ultimately only you know what you value the most.
7/19: RC: Staged IIIA, T2N1M0
approx 4.25 cm, low/mid rectum, mod. well diff.; lung micronodule
8/19-10/19 4 rds.FOLFOX neoadjuvant, 3 w/Oxiplatin (reduced 70-75%)
neoadjuvant chemorad 11/19
4 rounds FOLFOX July-August 2020
ncCR 10/20; biopsies neg
TAE 11/20, tumor cells removed
Chest CT 3/30/21 growth in 2 nodules (3 and 5mm)
VATS 12/8/21 sub-pleural met 7mm.
SBRT nodule 1/22
6/20/22 TAE rectal polyp benign)
NED from 3/22 - 3/23
4 cycles FOLFIRI
LUL VATS lobectomy for radio resistant met 7/7/23

roadrunner
Posts: 460
Joined: Sun Jan 12, 2020 8:46 pm

Re: Today’s CT Scan Of Lung Nodules——Panicking,Resigned To Dying?

Postby roadrunner » Wed Aug 11, 2021 6:35 pm

Well, it may be worth considering that curative intent can spring up along the way sometimes. Systemic chemo historically has had trouble eliminating pulmonary mets (though there are success stories), but it can often do part of the job. At which point sometimes another approach can be tried. Plus it can be helpful in cleaning out other stuff that may otherwise have shown up later. And time is a big deal. Again, just my perspective.
7/19: RC: Staged IIIA, T2N1M0
approx 4.25 cm, low/mid rectum, mod. well diff.; lung micronodule
8/19-10/19 4 rds.FOLFOX neoadjuvant, 3 w/Oxiplatin (reduced 70-75%)
neoadjuvant chemorad 11/19
4 rounds FOLFOX July-August 2020
ncCR 10/20; biopsies neg
TAE 11/20, tumor cells removed
Chest CT 3/30/21 growth in 2 nodules (3 and 5mm)
VATS 12/8/21 sub-pleural met 7mm.
SBRT nodule 1/22
6/20/22 TAE rectal polyp benign)
NED from 3/22 - 3/23
4 cycles FOLFIRI
LUL VATS lobectomy for radio resistant met 7/7/23


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