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Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Posted: Tue Jun 08, 2021 9:18 am
by Bpaint
I hope for you that your nodules aren’t metastasis. What does your oncologist think about the nodules being caused by the oxygen therapy?

I think lung nodules can pop up quickly though, unfortunately. My husband had a couple of lung nodules that disappeared after folfox, but then when he went off chemo for 2 months for surgery, his post surgery scan showed 10 new lung nodules. They are all small (all less than 5mm), but they popped up in less than 3 months. But, his cancer was more widespread than yours to begin with, with spread in para-aortic lymph nodes.

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Posted: Tue Jun 08, 2021 10:01 am
by beach sunrise
Hopefully its just the HBOT (if it is that) kicking in lymphatic drainage.
Keep us posted!

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Posted: Tue Jun 08, 2021 10:20 am
by claudine
My husband went from none to many small lung nodules in that period of time; but he also developed a large adrenal met.

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Posted: Tue Jun 08, 2021 10:36 am
by claudine
Yes he was! That's a good plan you've got :)
IMO any met that can be surgically removed is "preferable", if that makes sense. Unfortunately for my husband, one can hardly remove a vertebrae...

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Posted: Tue Jun 08, 2021 6:35 pm
by boxhill
Hyperbaric oxygen therapy. I did hbot 2 hours a day, five days a week.


Why? If it was to treat some lung infection, that itself could have caused the lung nodules.

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Posted: Wed Jun 09, 2021 3:24 pm
by boxhill
I'm sorry you had such bad radiation injuries.

If you don't mind telling us, did the treatment seem to help? So many people have nasty effects from radiation, but this is the first time I've seen this therapy mentioned.

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Posted: Thu Jun 10, 2021 10:21 am
by jts
I read about this a little when they found my lung met. Lung met doubling time for CRC can be as little as about 30 days, which it was in my case. Here's a random paper where they find a median doubling time of about 66 days, but a pretty wide range: "Impact of Surgical Resection on Metachronous Metastases of Colorectal Cancer According to Tumor Doubling Time" Miyake et al.

What doubling time you may be seeing depends a lot on what the starting point is. What was the sensitivity of your old scan? If some nodules were 2mm then (easily overlooked), and 6mm now, that is an increase in volume of 27x, or about 4.7 doublings, which would be a DT of 38 days. If your old scan was completely clear, not even a 0.5mm hint of a nodule, then that was over 1728x increase in volume, or over 10.7 doublings - pretty extreme for 6 months.

If you want, you can look at your own scans. A 6mm nodule on your new scan should be pretty easy to see on a CT. Then go look at the same area on your old scan and see if there is /anything/. In my case the lung met was actually visible on previous scans, but the radiologists had reported it "clean" because the nodule was so small.

I hope yours turn out to be nothing!

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Posted: Thu Jun 10, 2021 5:36 pm
by beach sunrise
What name, make and model of scan machine was used? Where did you have your scans?

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Posted: Fri Jun 11, 2021 5:00 am
by Brearmstrong
Hi there, I don’t think you mentioned it but how is your CEA? Is that hinting that something is going on? You said MSK confirmed disease. Based on shape, appearance?

Brenda

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Posted: Fri Jun 18, 2021 1:37 pm
by claudine
Well, it's now been 16 months since my husband's last Folfiri + Avastin cycle, and his lungs are still looking good: "Lungs, Pleura and Airways: Scattered calcified granulomata again noted unchanged. No new nodules identified". I hope yours disappear without treatment, prayingforccr, or that they're not mets in the first place, but if they are - know that systemic chemo can control them!

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Posted: Sat Jun 19, 2021 12:53 am
by rp1954
Our trials for alternative adjuncts' performance were faster, mostly around broad, sensitive blood work for us.
Some tissue work. Nonperformance has to be factored in, how to recognize it, and what to do about it soonest.
CEA may not be sensitive enough for your situation, alone (needs more series data at least for "noise" scatter) - my wife on her cancer treatment and low, baseline CEA had less CEA scatter than I do. Signal (meaningful CEA changes) to CEA noise ratio is important for detection and more informed decisions amongst blood panels. She had a lot of ant-inflammatories, from oral supplements to celecoxib and 1/4 aspirin to IVC. Imaging factors into the bloodwork too.

We would have rated your Tippens' protocol at least "insufficient" on the individual level and try to find another combination soonest, with or without the Tippens part.

Our alternative starting point after 8 yrs chemo is essentially chronomodulated oral 5FU chemo prodrugs, potent nutraceuticals, and celecoxib, then consider add-ons and observe responses across 6-12 blood panels for the cancer, and more for side effects, or side benefits. I am very impressed with 5FU compounds, in the right formulations, against most but not all CRC disease.
The thing is that -azole dewormers tend to be very harsh to combine with 5FU drugs, but not all dewormers are azoles (e.g. like IVM).

To us, the trick is to get enough punch to kill/damage/dissolve smaller mets, stop spread, and get advanced surgeries as necessary. In your case, the German laser lung treatment might be important to consider with better chemo. Conventional cyclic chemo treatments are too toxic for continuous treatment and most continuous regimes are too low powered without add-ons and changes. The add-ons are best targeted by some prior measurement, or observed for performance, or both.

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Posted: Sat Jun 19, 2021 1:15 pm
by beach sunrise
Interesting for sure.
Keep us updated on the Tippens protocol. I hope it does the trick and scan is clear.
I take xeloda and ivermectin as part of my personal ADAPT+++, so far I have a great response. Scan on Friday.

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Posted: Sat Jun 19, 2021 3:12 pm
by beach sunrise
Several small studies had success with IVM for anti-cancer is why I was interested. It is also very good for Covid too. A win win for me, protects me two ways in my opinion.
IVM is dr Rx and gotten thru a compounding pharmacy. Most likely you would have to go thru an alt dr (out of the box thinker) or plea your case with your current SOC dr and don't take NO for an answer but have papers to back you up with very nice attitude of "My Cancer, My Choice. Not yours or NCCN SOC." I end with "We will both sleep better at night knowing we tried our best for my benefit." For me, all my dr's know SOC is in the rearview mirror. Let's move on!!!

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Posted: Sat Jun 19, 2021 4:13 pm
by beach sunrise
All of my decisions for Tx is based on my mutations really.
IVC is a great add on for kRAS mutant, proven over and over to combat it.
Do you have mutation(s)?

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Posted: Sat Jun 19, 2021 4:42 pm
by beach sunrise
Yep, research and hammer the hell out of those mutations!