Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

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prayingforccr
Posts: 124
Joined: Sun Jun 28, 2020 4:44 pm

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Postby prayingforccr » Thu Jun 10, 2021 5:43 pm

beach sunrise wrote:What name, make and model of scan machine was used? Where did you have your scans?


The scans were done and read at sloan kettering.

I don’t see the name, make, model of the machine they used.

The scans in may were done at jupiter medical center.
Nov 2019: colonoscopy
Dec 2019: diagnosed with stage 3 rectal cancer 6+cm tumor
Jan-mar 2020: 20 sessions of radiation, mon-fri capecetibine, mon-fri clinical trial drug m3814
Apr 2020: tumor/scar 3.7cm
July 2020: began 8 treatmentsFOLFOX
August 2020: ct scan reveals scarbed reduced to 2.7cm CEA is 1.5
Nov 2020: Primary tumor had complete response. Possible tumor deposits on latest mri. Biopsy negative for cancer.
May 2021: Multiple lung nodules (3-6mm) on ct scan

Brearmstrong
Posts: 107
Joined: Sun Mar 26, 2017 3:24 pm
Location: CT

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Postby Brearmstrong » Fri Jun 11, 2021 5:00 am

Hi there, I don’t think you mentioned it but how is your CEA? Is that hinting that something is going on? You said MSK confirmed disease. Based on shape, appearance?

Brenda
48 F Jan 17 2 sons
tumor appendix/colon
Muc Adeno 4cm
mod diff G2 T4aN2
nodes 8/50
CEA 4.6 after surgery <.05
KRAS G12D MSS
FOLFOX Apr-sep 17
Clean CT Jul 2017, oct 17, CEA 3.4, 8.1. May 18 2.3,1.0,1.3, 1.3, 1.0, 2.3, 2.2, 2.1,2.2,1.6,1.4,1.5,2.8,2.2
Oct 2017 clean CT
Nov 17 PET para aortic nodes Stage IV
Folfori w/avastin Dec 17
May 18- surgery on nodes xeloda continues
Aug 18-CT NED Clear CT's Nov 18-May 20
July 20- it’s back! Rt ovary Full hysterectomy CEA 1.7 chemo break

prayingforccr
Posts: 124
Joined: Sun Jun 28, 2020 4:44 pm

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Postby prayingforccr » Fri Jun 11, 2021 6:03 am

CEA is 2.6.

Both mskcc and jupiter medical indicated suspected metastasis because of history of rectal cancer and how they reflected the contrast, but they are currently too small to biopsy.

So, not 100%.

I’m hoping they are a bunch of atelectasis or mucus plugs from hyperbaric oxygen therapy.

I’m going to be getting new scans in august.
Nov 2019: colonoscopy
Dec 2019: diagnosed with stage 3 rectal cancer 6+cm tumor
Jan-mar 2020: 20 sessions of radiation, mon-fri capecetibine, mon-fri clinical trial drug m3814
Apr 2020: tumor/scar 3.7cm
July 2020: began 8 treatmentsFOLFOX
August 2020: ct scan reveals scarbed reduced to 2.7cm CEA is 1.5
Nov 2020: Primary tumor had complete response. Possible tumor deposits on latest mri. Biopsy negative for cancer.
May 2021: Multiple lung nodules (3-6mm) on ct scan

Claudine
Posts: 524
Joined: Tue Mar 12, 2019 2:41 pm
Location: Montana

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Postby Claudine » Fri Jun 18, 2021 1:37 pm

Well, it's now been 16 months since my husband's last Folfiri + Avastin cycle, and his lungs are still looking good: "Lungs, Pleura and Airways: Scattered calcified granulomata again noted unchanged. No new nodules identified". I hope yours disappear without treatment, prayingforccr, or that they're not mets in the first place, but if they are - know that systemic chemo can control them!
Wife of Dx 04/18 (51 yo). MSS, KRAS G12A
No primary (involuted?)
Lytic tumor L4 vertebrae, EBRT 04/18, SBRT 02/19
Resect small intestine 05/18 (no cancer - Crohn's)
Failed adjuvant Xelox
Folfiri + Avastin 03/19 to 01/20
6.7 cm left adrenal mass 03/19, successful resection 02/20
CEA since 03/19: high 58, low 3.2, now 75.5
Scan 03/19: Multiple small lung nodules, now gone/calcified
PET 04/20 uptake by L4
L3-L4-L5 fusion surgery and partial corpectomy 05/20
Scan 06/17/2021: stable

prayingforccr
Posts: 124
Joined: Sun Jun 28, 2020 4:44 pm

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Postby prayingforccr » Fri Jun 18, 2021 5:36 pm

Thank you, Claudine.

It’s hard for me to not fear the worst, but I do think it unusual to go from ZERO to NINE nodules in all lobes of the lung in a matter of five months.

The variable was the hyperbaric oxygen therapy I began in december and continued up until the scan, so I am really, really hoping that what was picked up was treatment results from the hbot (atelectasis/mucous plugs/granuloma).

If it isn’t, I don’t think I’ll be around long :(

I am doing the Tippens Protocol in the interim and hoping for the best.

Scans in august.
Nov 2019: colonoscopy
Dec 2019: diagnosed with stage 3 rectal cancer 6+cm tumor
Jan-mar 2020: 20 sessions of radiation, mon-fri capecetibine, mon-fri clinical trial drug m3814
Apr 2020: tumor/scar 3.7cm
July 2020: began 8 treatmentsFOLFOX
August 2020: ct scan reveals scarbed reduced to 2.7cm CEA is 1.5
Nov 2020: Primary tumor had complete response. Possible tumor deposits on latest mri. Biopsy negative for cancer.
May 2021: Multiple lung nodules (3-6mm) on ct scan

rp1954
Posts: 1550
Joined: Mon Jun 13, 2011 1:13 am

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Postby rp1954 » Sat Jun 19, 2021 12:53 am

Our trials for alternative adjuncts' performance were faster, mostly around broad, sensitive blood work for us.
Some tissue work. Nonperformance has to be factored in, how to recognize it, and what to do about it soonest.
CEA may not be sensitive enough for your situation, alone (needs more series data at least for "noise" scatter) - my wife on her cancer treatment and low, baseline CEA had less CEA scatter than I do. Signal (meaningful CEA changes) to CEA noise ratio is important for detection and more informed decisions amongst blood panels. She had a lot of ant-inflammatories, from oral supplements to celecoxib and 1/4 aspirin to IVC. Imaging factors into the bloodwork too.

We would have rated your Tippens' protocol at least "insufficient" on the individual level and try to find another combination soonest, with or without the Tippens part.

Our alternative starting point after 8 yrs chemo is essentially chronomodulated oral 5FU chemo prodrugs, potent nutraceuticals, and celecoxib, then consider add-ons and observe responses across 6-12 blood panels for the cancer, and more for side effects, or side benefits. I am very impressed with 5FU compounds, in the right formulations, against most but not all CRC disease.
The thing is that -azole dewormers tend to be very harsh to combine with 5FU drugs, but not all dewormers are azoles (e.g. like IVM).

To us, the trick is to get enough punch to kill/damage/dissolve smaller mets, stop spread, and get advanced surgeries as necessary. In your case, the German laser lung treatment might be important to consider with better chemo. Conventional cyclic chemo treatments are too toxic for continuous treatment and most continuous regimes are too low powered without add-ons and changes. The add-ons are best targeted by some prior measurement, or observed for performance, or both.
watchful, active researcher and caregiver for stage IVb/c CC. surgeries 4/10 sigmoid etc & 5/11 para-aortic LN cluster; 8 yrs immuno-Chemo for mCRC; now no chemo
most of 2010 Life Extension recommendations and possibilities + more, some (much) higher, peaking ~2011-12, taper to almost nothing mid 2018, mostly IV C

prayingforccr
Posts: 124
Joined: Sun Jun 28, 2020 4:44 pm

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Postby prayingforccr » Sat Jun 19, 2021 8:09 am

I’m not sure I understand rp1954.

Do you not like the Tippens Protocol for a specific reason?

I’m taking fenbendazole dissolved in dmso/curcumin/full spectrum cbd oil/resveratrol/vitamin d3/vitamin b complex/turkey tail mushrooms/dha each day.

It’s the best I could come up with.
Nov 2019: colonoscopy
Dec 2019: diagnosed with stage 3 rectal cancer 6+cm tumor
Jan-mar 2020: 20 sessions of radiation, mon-fri capecetibine, mon-fri clinical trial drug m3814
Apr 2020: tumor/scar 3.7cm
July 2020: began 8 treatmentsFOLFOX
August 2020: ct scan reveals scarbed reduced to 2.7cm CEA is 1.5
Nov 2020: Primary tumor had complete response. Possible tumor deposits on latest mri. Biopsy negative for cancer.
May 2021: Multiple lung nodules (3-6mm) on ct scan

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beach sunrise
Posts: 457
Joined: Thu Mar 05, 2020 7:14 pm

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Postby beach sunrise » Sat Jun 19, 2021 1:15 pm

Interesting for sure.
Keep us updated on the Tippens protocol. I hope it does the trick and scan is clear.
I take xeloda and ivermectin as part of my personal ADAPT+++, so far I have a great response. Scan on Friday.
8/19 RC CEA 82.6 T3N0M0
Neoadj 5FU/rad 6 wk
High dose IVC 1 1/2 wks before surgery. Continue still twice a week
Surg 1/20 APR - margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24/post 5.9
FOLFOX
7 rds 6-10 CEA 11.4 No more
7/20 CEA 11.1, 8.8
8/20 CEA 7.8
9/20 CEA 8.8, 9, 8.6
10/20 CEA 8.1
11/20 CEA 8's
12/20 CEA 8's & 9's
ADAPT+++ TM drug
MHL1+
PMS2+
MSH2+
MSH6+
POLD1 , KRAS Q61H
Chem-sens test NCI "Test failed, neo adj CR worked. Not enough ca cells to test"

prayingforccr
Posts: 124
Joined: Sun Jun 28, 2020 4:44 pm

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Postby prayingforccr » Sat Jun 19, 2021 2:34 pm

beach sunrise wrote:Interesting for sure.
Keep us updated on the Tippens protocol. I hope it does the trick and scan is clear.
I take xeloda and ivermectin as part of my personal ADAPT+++, so far I have a great response. Scan on Friday.


Wishing you a clean scan.......I may need to bend your ear on the ADAPT+++

My next scans are in august, so I will have been on the Tippens Protocol for about 12 weeks.

How would I dose, procure and take the ivermectin? What form to buy?

Very curious on my end as well.
Nov 2019: colonoscopy
Dec 2019: diagnosed with stage 3 rectal cancer 6+cm tumor
Jan-mar 2020: 20 sessions of radiation, mon-fri capecetibine, mon-fri clinical trial drug m3814
Apr 2020: tumor/scar 3.7cm
July 2020: began 8 treatmentsFOLFOX
August 2020: ct scan reveals scarbed reduced to 2.7cm CEA is 1.5
Nov 2020: Primary tumor had complete response. Possible tumor deposits on latest mri. Biopsy negative for cancer.
May 2021: Multiple lung nodules (3-6mm) on ct scan

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beach sunrise
Posts: 457
Joined: Thu Mar 05, 2020 7:14 pm

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Postby beach sunrise » Sat Jun 19, 2021 3:12 pm

Several small studies had success with IVM for anti-cancer is why I was interested. It is also very good for Covid too. A win win for me, protects me two ways in my opinion.
IVM is dr Rx and gotten thru a compounding pharmacy. Most likely you would have to go thru an alt dr (out of the box thinker) or plea your case with your current SOC dr and don't take NO for an answer but have papers to back you up with very nice attitude of "My Cancer, My Choice. Not yours or NCCN SOC." I end with "We will both sleep better at night knowing we tried our best for my benefit." For me, all my dr's know SOC is in the rearview mirror. Let's move on!!!
8/19 RC CEA 82.6 T3N0M0
Neoadj 5FU/rad 6 wk
High dose IVC 1 1/2 wks before surgery. Continue still twice a week
Surg 1/20 APR - margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24/post 5.9
FOLFOX
7 rds 6-10 CEA 11.4 No more
7/20 CEA 11.1, 8.8
8/20 CEA 7.8
9/20 CEA 8.8, 9, 8.6
10/20 CEA 8.1
11/20 CEA 8's
12/20 CEA 8's & 9's
ADAPT+++ TM drug
MHL1+
PMS2+
MSH2+
MSH6+
POLD1 , KRAS Q61H
Chem-sens test NCI "Test failed, neo adj CR worked. Not enough ca cells to test"

prayingforccr
Posts: 124
Joined: Sun Jun 28, 2020 4:44 pm

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Postby prayingforccr » Sat Jun 19, 2021 4:07 pm

beach sunrise wrote:Several small studies had success with IVM for anti-cancer is why I was interested. It is also very good for Covid too. A win win for me, protects me two ways in my opinion.
IVM is dr Rx and gotten thru a compounding pharmacy. Most likely you would have to go thru an alt dr (out of the box thinker) or plea your case with your current SOC dr and don't take NO for an answer but have papers to back you up with very nice attitude of "My Cancer, My Choice. Not yours or NCCN SOC." I end with "We will both sleep better at night knowing we tried our best for my benefit." For me, all my dr's know SOC is in the rearview mirror. Let's move on!!!



Thinking ivc and fenben
Nov 2019: colonoscopy
Dec 2019: diagnosed with stage 3 rectal cancer 6+cm tumor
Jan-mar 2020: 20 sessions of radiation, mon-fri capecetibine, mon-fri clinical trial drug m3814
Apr 2020: tumor/scar 3.7cm
July 2020: began 8 treatmentsFOLFOX
August 2020: ct scan reveals scarbed reduced to 2.7cm CEA is 1.5
Nov 2020: Primary tumor had complete response. Possible tumor deposits on latest mri. Biopsy negative for cancer.
May 2021: Multiple lung nodules (3-6mm) on ct scan

User avatar
beach sunrise
Posts: 457
Joined: Thu Mar 05, 2020 7:14 pm

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Postby beach sunrise » Sat Jun 19, 2021 4:13 pm

All of my decisions for Tx is based on my mutations really.
IVC is a great add on for kRAS mutant, proven over and over to combat it.
Do you have mutation(s)?
8/19 RC CEA 82.6 T3N0M0
Neoadj 5FU/rad 6 wk
High dose IVC 1 1/2 wks before surgery. Continue still twice a week
Surg 1/20 APR - margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24/post 5.9
FOLFOX
7 rds 6-10 CEA 11.4 No more
7/20 CEA 11.1, 8.8
8/20 CEA 7.8
9/20 CEA 8.8, 9, 8.6
10/20 CEA 8.1
11/20 CEA 8's
12/20 CEA 8's & 9's
ADAPT+++ TM drug
MHL1+
PMS2+
MSH2+
MSH6+
POLD1 , KRAS Q61H
Chem-sens test NCI "Test failed, neo adj CR worked. Not enough ca cells to test"

prayingforccr
Posts: 124
Joined: Sun Jun 28, 2020 4:44 pm

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Postby prayingforccr » Sat Jun 19, 2021 4:28 pm

beach sunrise wrote:All of my decisions for Tx is based on my mutations really.
IVC is a great add on for kRAS mutant, proven over and over to combat it.
Do you have mutation(s)?


Somatic alterations detected in this sample:
Gene Type Alteration Location Additional Information
+: A glossary of terms and icons used in this report can be found after the "Test and Methodology" section . β: MSI Note: The MSIsensor score is 0.75.
RefSeq IDs for the genes with reported variants along with a list of all 505 genes can be found on the last page
FDA Approved and/or NCCN recommended biomarker:

Mutations

KRAS Missense Mutation G13D (c.38G>A) exon 2 MAF: 24.0%
TP53 Frameshift Deletion V97Afs*26 (c.290del) exon 4 MAF: 29.6%
APC Frameshift Insertion S1426Rfs*48 (c.4276_4277dupAG) exon 16 MAF: 26.2%
GAB1 Missense Mutation T606R (c.1817C>G) exon 9 MAF: 11.0%
TCF7L2 Missense Mutation P415R (c.1244C>G) exon 11 MAF: 15.8%
MutatCopy Number Alterations
RTEL1 Whole gene Amplification 20q13.33 FC: 2.0

I’m a smart guy. Ive been doing my research. I don’t know what any of these means to me currently.
Nov 2019: colonoscopy
Dec 2019: diagnosed with stage 3 rectal cancer 6+cm tumor
Jan-mar 2020: 20 sessions of radiation, mon-fri capecetibine, mon-fri clinical trial drug m3814
Apr 2020: tumor/scar 3.7cm
July 2020: began 8 treatmentsFOLFOX
August 2020: ct scan reveals scarbed reduced to 2.7cm CEA is 1.5
Nov 2020: Primary tumor had complete response. Possible tumor deposits on latest mri. Biopsy negative for cancer.
May 2021: Multiple lung nodules (3-6mm) on ct scan

User avatar
beach sunrise
Posts: 457
Joined: Thu Mar 05, 2020 7:14 pm

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Postby beach sunrise » Sat Jun 19, 2021 4:42 pm

Yep, research and hammer the hell out of those mutations!
8/19 RC CEA 82.6 T3N0M0
Neoadj 5FU/rad 6 wk
High dose IVC 1 1/2 wks before surgery. Continue still twice a week
Surg 1/20 APR - margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24/post 5.9
FOLFOX
7 rds 6-10 CEA 11.4 No more
7/20 CEA 11.1, 8.8
8/20 CEA 7.8
9/20 CEA 8.8, 9, 8.6
10/20 CEA 8.1
11/20 CEA 8's
12/20 CEA 8's & 9's
ADAPT+++ TM drug
MHL1+
PMS2+
MSH2+
MSH6+
POLD1 , KRAS Q61H
Chem-sens test NCI "Test failed, neo adj CR worked. Not enough ca cells to test"

prayingforccr
Posts: 124
Joined: Sun Jun 28, 2020 4:44 pm

Re: Unusual To Go From Zero To Nine Lung Nodules In 6 Months?

Postby prayingforccr » Sat Jun 19, 2021 4:57 pm

beach sunrise wrote:Yep, research and hammer the hell out of those mutations!


On it.

What do you think of my original premise? Is it odd/rare to go from ZERO to NINE small (3-5mm) lung nodules, in all lobes, within 6 months?

The variable from the nov vs the may scan was the 2hrs a day hyperbaric oxygen therapy I did 5 days a week.

I’m hoping whatever was picked up is treatment effect (inflammation/atelectasis/mucous plugs) from the hbot.
Nov 2019: colonoscopy
Dec 2019: diagnosed with stage 3 rectal cancer 6+cm tumor
Jan-mar 2020: 20 sessions of radiation, mon-fri capecetibine, mon-fri clinical trial drug m3814
Apr 2020: tumor/scar 3.7cm
July 2020: began 8 treatmentsFOLFOX
August 2020: ct scan reveals scarbed reduced to 2.7cm CEA is 1.5
Nov 2020: Primary tumor had complete response. Possible tumor deposits on latest mri. Biopsy negative for cancer.
May 2021: Multiple lung nodules (3-6mm) on ct scan


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