catstaff wrote:Partially necrotic tumors are common because a lot of them outgrow their blood supply. Also the new blood vessels they grow are usually leaky and don't deliver blood very well. That's one thing Avastin (bevacizumab) does--it reduces the leakage and normalizes the blood flow, which is actually a good thing since it means the other chemo (it is not used alone) can access the tumor better.
I don't recall when this tumor was found on your father but it was fairly large, correct? My husband has a tumor in a very similar location, against the sacrum. I am going to try to talk them into using radiation on the remnant. His surgeon said that there are a lot of blood vessels there so surgery isn't an option, but radiation works. However, it puts the small intestine at risk. His tumor has shrunk dramatically on folfiri/bev which should make radiation safer. Have they discussed trying to shrink his tumor before radiation?
catstaff wrote:How did they know there was a microscopic leftover? Margins weren't clear? Margins were supposedly clear on my husband but he still got a similar recurrence, though his may be a lymph node. I am not sure whether it automatically means it's aggressive if it outgrows its blood supply. I suppose it does indicate it's growing rapidly; but nearly all large tumors will have some necrotic areas.
Leaky vessels may be bad but it's what you get; the vessels a tumor induces to grow are abnormal.
There was no particular plan to shrink my husband's mets for radiation because I don't think there was a plan to use radiation on them. I am just going to try to argue to get rid of the largest ones entirely. The others were very small lymph-node mets, too small to biopsy or to be obvious on CT. I am hoping they can be managed with chemo.
boxhill wrote:worriedson, if you would do a signature it would really help the rest of us follow what is going on with your father.
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