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Proteinuria from bevacizumab

Posted: Thu May 27, 2021 6:56 pm
by catstaff
DH has (low) Grade 2 proteinuria after five cycles of folfiri+bevacizumab. He does not have hypertension, at least not yet. There does not seem to be an established treatment other than suspending or possibly discontinuing bevacizumab. I am concerned that it may be the secret ingredient making the chemo work this time and am worried they may stop it. Does anybody have experience with this? Does it tend to become progressive or just bounce around in Grade 2?

Some clinicians have apparently treated it with angiotensin-receptor blockers with success but I don't know what his onc will think of that.

Re: Proteinuria from bevacizumab

Posted: Tue Jan 31, 2023 10:08 am
by crikklekay
Hello!

Sorry to pop in on such an old thread, but I wanted to see how your husband is doing, and how you guys dealt with the proteinuria? We just landed in the same boat, and I'm terrified they will want to stop the Avastin. We're waiting to hear how his oncologist wants to handle it. The Avastin is working well and his options are limited for future treatments, so I'm scared to stop the Avastin. But I also don't want my husband to have horrible kidney damage either. It feels like we're in a lose-lose situation.

Re: Proteinuria from bevacizumab

Posted: Tue Jan 31, 2023 8:08 pm
by rp1954
Might be worth while to shop several naturopaths and integrative/orthomolecular/functional medicine MD/DO drs for nutraceutical kidney support. I seldom find a full set of good answers in one spot.

~20 years ago, after a trainwreck with a soon withdrawn antibiotic for refractory bronchitis, I had rising foamy, proteinuria and neuropathies, as some of the side effects to serious malabsorption (worst month, I lost 30 lbs despite some huge meals.) This experience made me more sympathetic to celiacs, that in the early 2000s were reported to take an average of 11 years for a diagnosis after visiting 20+ doctors. However my list of tested nutrients for relief, was twice as long, and much higher potency, than SOC nutrition for celiacs.

The malabsorption was much ameliorated with pancreatic enzymes, and later, even better with a digestive acidulant, betaine hydrochloride.

The foam and the neuropathies disappeared after several weeks megavitamin treatment with enhanced to obscene amounts of vitamin B1, B2, B3, B6 and B12 (and vitamin C, CoQ10 and magnesium) that have a certain amount of literature on kidney injuries, diabetes and reversing oxalates.

Re: Proteinuria from bevacizumab

Posted: Mon Feb 13, 2023 1:32 am
by Achilles Torn
My experience after years of Bev/Avastin was constant proteinuria even after an extended break. My oncologist decided that, since the level was in the abnormal but not dangerous range and since all other tests were fine, to restart Avastin. Since then the number has remained elevated but has not increased much at all.

I have been on another extended break after lung surgery but it will be interesting to see where my numbers go when I restart Chemo in a month.

Just my experience.

AT