DH has (low) Grade 2 proteinuria after five cycles of folfiri+bevacizumab. He does not have hypertension, at least not yet. There does not seem to be an established treatment other than suspending or possibly discontinuing bevacizumab. I am concerned that it may be the secret ingredient making the chemo work this time and am worried they may stop it. Does anybody have experience with this? Does it tend to become progressive or just bounce around in Grade 2?
Some clinicians have apparently treated it with angiotensin-receptor blockers with success but I don't know what his onc will think of that.
D/H Dx 10/2019 RC age 61
Clinical T4bN2M1a (common iliac and para-aortic lymph nodes)
MSS KRAS G12D
CRT 11/19-1/20 FOLFOX 3/20-7/20
Pelvic exenteration w/LAR 8/20
ypT4bN0Mx G3 0/14 nodes LVI not seen PNI-
CEA 10/19:20, 1/20-11/20:1.6, 4.3, 3.4, 2.7, 2/21:9.0 3/21:18,40 4/21:28,19, 5/21:13.3,8.6
PET 3/21 recurrence in distal nodes, L5 vertebra, pelvis