Proteinuria from bevacizumab

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Joined: Wed Mar 03, 2021 11:37 am

Proteinuria from bevacizumab

Postby catstaff » Thu May 27, 2021 6:56 pm

DH has (low) Grade 2 proteinuria after five cycles of folfiri+bevacizumab. He does not have hypertension, at least not yet. There does not seem to be an established treatment other than suspending or possibly discontinuing bevacizumab. I am concerned that it may be the secret ingredient making the chemo work this time and am worried they may stop it. Does anybody have experience with this? Does it tend to become progressive or just bounce around in Grade 2?

Some clinicians have apparently treated it with angiotensin-receptor blockers with success but I don't know what his onc will think of that.
D/H Dx 10/2019 RC age 61
Clinical T4bN2M1a (common iliac and para-aortic lymph nodes)
CRT 11/19-1/20 FOLFOX 3/20-7/20
Pelvic exenteration w/LAR 8/20
ypT4bN0Mx G3 0/14 nodes LVI not seen PNI-
CEA 10/19:20, 1/20-11/20:1.6, 4.3, 3.4, 2.7, 2/21:9.0 3/21:18,40 4/21:28,19, 5/21:13.3,8.6
PET 3/21 recurrence in distal nodes, L5 vertebra, pelvis
FOLFIRI+bev 3/21-

Posts: 142
Joined: Thu Feb 15, 2018 9:47 am
Location: Richmond, VA

Re: Proteinuria from bevacizumab

Postby crikklekay » Tue Jan 31, 2023 10:08 am


Sorry to pop in on such an old thread, but I wanted to see how your husband is doing, and how you guys dealt with the proteinuria? We just landed in the same boat, and I'm terrified they will want to stop the Avastin. We're waiting to hear how his oncologist wants to handle it. The Avastin is working well and his options are limited for future treatments, so I'm scared to stop the Avastin. But I also don't want my husband to have horrible kidney damage either. It feels like we're in a lose-lose situation.
Caring for DH John
Stage IIIC, Lymph nodes: 6/22
Chemo: FOLFOX (6)
12/17 ER and emergency surgery
02/18 Hospital w/MSSA infected port, PICC line inserted, chest CT scan showed septic emboli & blood clots
03/18 Hospital w/CDIFF
08/18 CT Scan Clear, NEMD
2018/2019/2021 Colonoscopy Clear
2019/2020/2021/2022 CT Scan Clear
2021 PET scan & MRI show one spot on liver
08/21 Liver surgery to remove spot, confirmed mCRC. Now Stage IV
09/21 Start Folfiri + Avastin
03/22 CEA Rise, continuing chemo

Posts: 1638
Joined: Mon Jun 13, 2011 1:13 am

Re: Proteinuria from bevacizumab

Postby rp1954 » Tue Jan 31, 2023 8:08 pm

Might be worth while to shop several naturopaths and integrative/functional medicine MD/DO drs for nutraceutical kidney support.
I seldom find a full set of good answers in one spot.

20 years ago, after a trainwreck with a soon withdrawn antibiotic for refractory bronchitis, I had rising foamy, proteinuria and neuropathies, as some of the side effects to serious malabsorption (worst month, I lost 30 lbs despite some huge meals.) This experience made me more sympathetic to celiacs, that in the early 2000s were reported to take an average of 11 years for a diagnosis after visiting 20+ doctors. However my list of tested nutrients for relief, was twice as long, and much higher potency, than SOC nutrition for celiacs.

The malabsorption was much ameliorated with pancreatic enzymes, and later, even better with a digestive acidulant, betaine hydrochloride.
The foam and the neuropathies disappeared after several weeks megavitamin treatment with obscene amounts of vitamin B1, B2, B3, B6 and B12 (and vitamin C, CoQ10 and magnesium) that have a certain amount of literature on kidney injuries, diabetes and reversing oxalates.
watchful, active researcher and caregiver for stage IVb/c CC. surgeries 4/10 sigmoid etc & 5/11 para-aortic LN cluster; 8 yrs immuno-Chemo for mCRC; now no chemo
most of 2010 Life Extension recommendations and possibilities + more, some (much) higher, peaking ~2011-12, taper to almost nothing mid 2018, mostly IV C

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