I did two rounds of FOLFOX, 4 cycles each time. The first time ALT and AST were interesting indeed. I just did a quick look at the results, and saw values as high as AST 129 and ALT 299. They may have gone higher, but that range seems right for the higher end going by memory. My medical oncologist was never too concerned, but he did hold Oxi once and that seemed to help. I remember debating whether it was the Lovenox I was taking or the Oxi, but he was pretty strong about it being the Oxi, and the values did return to normal after chemo (though there is some literature on the body “acclimating” to Lovenox, so?) I did a lot of research at the time, and overall I don’t think it was a big deal. For what it’s worth, FOLFOX reduced my rectal tumor from close to 5 cm to a nCCR.
7/19: Rectal cancer: Initially staged as IIIA, T2N1M0
Initially approx 4.25 cm, low/mid rectum, mod. well diff. adenocarcinoma
8/22 -10/14 4 rounds FOLFOX neoadjuvant, 3 w/Oxiplatin (lots of side effects/reduced size est. 70-75%)
Switched to neoadjuvant chemorad in 11/19 (Xeloda and approx. IMRT, 60 Gy, 33 fractions)
Trying to achieve cCR.