All I can say is that CT with contrast did *not* catch my husband's mets.
In the MSK study described in the ASCO Post above, they say "no confirmed elevation greater than 35 ng/mL was a false-positive."
beach sunrise wrote:... I found this:
"The superiority of PET over CT alone for detection of extrahepatic disease was also suggested in a systematic overview of retrospective data that utilized a scoring system to weigh the individual studies according to the quality of the data and the clinical impact of the radiographic findings [27]. For the six articles judged to be of the highest quality [31-36], the pooled sensitivity and specificity for PET were 80 and 92 percent, respectively, for hepatic disease, and 91 and 98 percent, respectively, for extrahepatic disease [27]. The corresponding values for CT were 83 and 84 percent, respectively, for hepatic metastases, and 61 and 91 percent, respectively, for extrahepatic metastases. The percent change in clinical management from the performance of PET ranged from 20 to 32 percent (average 25 percent).
The results of restaging PET scans (particularly if negative) must be interpreted in the context of recent therapy. Chemotherapy may reduce the sensitivity of PET for the detection of liver metastases, thought due to decreased cellular metabolic activity following chemotherapy [37-39]. In one study, the false negative rate for hepatic metastases of a PET scan performed within four weeks of chemotherapy was 87 percent [38]. Thus, surgical decisions should not be based on PET scan results in the liver..."
Reference ==> https://www.uptodate.com/contents/management-of-potentially-resectable-colorectal-cancer-liver-metastases#!.
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