Postby catstaff » Wed May 19, 2021 7:51 am
My understanding is that she has not had conventional chemo yet. The inclusion criteria for this trial say that they may accept patients who have declined conventional treatment, but in most trials they'd prefer patients who have had it. For one thing, they don't want patients skipping standard of care for what is by definition an experimental, unproven treatment. Keep in mind that most new treatments fail and that seems especially true for cancer trials, sadly. What works in cells or even mice may not work in humans. For another thing, even when they are not yet comparing it to standard treatments (that would be a Phase III trial) they would like to look for signs that it works better. Right now vaccines seem especially speculative since they have a long history of flopping clinically. I am optimistic they'll figure it out but it may be a few years yet.
If you are still interested you could contact the administrator and she might be able to give you an idea of whether they'd accept your mother.
D/H Dx 10/2019 RC age 61
Clinical T4bN2M1a (common iliac and para-aortic lymph nodes)
MSS KRAS G12D
CRT 11/19-1/20 FOLFOX 3/20-7/20
Pelvic exenteration w/LAR 8/20
ypT4bN0Mx G3 0/14 nodes LVI not seen PNI-
CEA 10/19:20, 1/20-11/20:1.6, 4.3, 3.4, 2.7, 2/21:9.0 3/21:18,40 4/21:28,19, 5/21:13.3,8.6
PET 3/21 recurrence in distal nodes, L5 vertebra, pelvis
FOLFIRI+bev 3/21-