5-fu 200ml push - should I keep it?

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CancerBum21
Posts: 29
Joined: Fri Feb 26, 2021 6:27 am

5-fu 200ml push - should I keep it?

Postby CancerBum21 » Sun May 02, 2021 1:44 pm

I'm going into my 3rd round of FOLFOX. Woot half way... My oncologist recommended I drop the 200 mL 5-FU push after my first round because I had pretty bad nausea. I wasn't ready to drop the dosage and we ended-up adding emend. I kind of felt like it was giving up in a way. The emend worked pretty well the first 3 days but day 4 and 5 sucked. Taking 8 mg ondansetron as needed and prochlorperazine 10 mg as needed.

My oncologist does not seem to think the 200ml push of 5-FU does anything besides give side effects. Has anyone else dropped the push? Thoughts? info?
34/M
DX:(Rectal Cancer) 2/15/21
Stage: T1N0M0
TAMIS Surgery 3/10/21
Pathology: T1NxM0 - LIV positive, 1/1 lymph positive Stage IIIA
FOLFOX 6 rounds
Radation & Xelota 5 weeks

Brearmstrong
Posts: 112
Joined: Sun Mar 26, 2017 3:24 pm
Location: CT

Re: 5-fu 200ml push - should I keep it?

Postby Brearmstrong » Sun May 02, 2021 4:55 pm

I had to drop it after 7 rounds but it was because of low white blood counts even with nuelasta. Did it make a difference? Who knows but I did have a recurrence 2 months after finishing folfox.
Hopefully you can get the nausea under control. Medical marijuana was a life saver for me and I dropped all the prescription meds and felt much better.
-Brenda
50 F diag 1/17
Muc Adeno 4cm
mod diff G2 T4aN2
nodes 8/50
CEA 4.6 after surgery <.05
KRAS G12D MSS
FOLFOX Apr-sep 17
Nov 17 PET p aortic nodes Stage IV
Folfori w/avastin
May 18 surgery on nodes xeloda 2yr
Aug 18-May 20 NED
July 20 hysterectomy
July 21 vats right lung
Clinical trial- failed liver Mets biopsy shows now poorly differentiated carcinoma.
HAI pump at MSK may 2022
Nov met to pancreas- causing pain
Radiation ablation to pancreas Dec 22
New lung Mets watch and wait

CancerBum21
Posts: 29
Joined: Fri Feb 26, 2021 6:27 am

Re: 5-fu 200ml push - should I keep it?

Postby CancerBum21 » Sun May 02, 2021 5:32 pm

Thanks! You're the second person today to suggest medical marijuana. I'm going to have to check it out. As much as a bad ass I am at dealing with pain, nausea is my kryptonite. Do you know if any of the CBD stuff has the same effect?
34/M
DX:(Rectal Cancer) 2/15/21
Stage: T1N0M0
TAMIS Surgery 3/10/21
Pathology: T1NxM0 - LIV positive, 1/1 lymph positive Stage IIIA
FOLFOX 6 rounds
Radation & Xelota 5 weeks

zephyr
Posts: 363
Joined: Thu Aug 18, 2016 7:31 am

Re: 5-fu 200ml push - should I keep it?

Postby zephyr » Sun May 02, 2021 7:09 pm

I don't think you will get the same effect from CBD alone but all you probably need is a touch of THC. The way one person explained it to me was like this: think of Michael Jordan and Scottie Pippin. All by themselves they are each superstars but put them together and the whole is greater than the sum of the parts -- that's the combination of CBD and THC. If you want the benefit of both but don't want the head high, maybe look for an edible in the 5:1 range, that's 5 parts CBD to 1 part THC. That should be just enough THC to do the trick, and I think you'll find the head high roughly similar to a glass of wine.

Another idea for nausea is a ReliefBand. It's like an electronic SeaBand. You can buy one on Amazon and return it within ... I think 30 days ... if it doesn't work for you. You put in on at the very first sign of nausea, that kind of aura feeling like something's starting to go sideways. It gives a small zap to the acupressure point on the inside of your wrist. It's really helped me.

https://www.amazon.com/Reliefband-1-5-Motion-Morning-Sickness/dp/B00PG4NUOS

For the record: I don't own stock in Amazon or ReliefBand :wink: ...sure wish I did!
Nov-2009 Early stage CRC, routine colonoscopy
2010-2014 F/U colonoscopies, all clear
Jun-2016 CRC during F/U colonoscopy, surgery, Stage 4, KRAS, MSS
Aug-2016-May-2018 Folfox, 5FU, Folfiri & Avastin
Aug/Sep-2018 YAG laser surgeries (Germany), 11 nodules removed
Nov-2018 clean CT scan
Mar-2019 New lung nodules
Apr-2019 Dec-2020 Xeloda/Avastin, SBRT, cont. Xeloda/Avastin
Mar-2021 Forfiri/Avastin
Mar-2022 Ablation & Thoracotomy
Feb-2023 Folfiri & Avastin
Nov-2023 Xeloda & Avastin

Nor Cal
Posts: 89
Joined: Sun Dec 06, 2020 8:18 pm

Re: 5-fu 200ml push - should I keep it?

Postby Nor Cal » Sun May 02, 2021 7:50 pm

I didn't do the push while I was on FOLFOXIRI. Now that we've dropped the Oxi I am using the push. Nausea seems to vary dramatically from cycle to cycle.
Dx June 2020, stage IV, w liver mets in both lobes. M, age 50. Right-sided colon tumor. CEA 120.
BRAF+ TMB 5% MSS TDL1-1%
July 2020 - Present: 55 cycles chemo (All the various 5-FU regimens)
December 2020 - February 2021 Y90 Radioembolization, Chemoembolization x2

User avatar
beach sunrise
Posts: 1033
Joined: Thu Mar 05, 2020 7:14 pm

Re: 5-fu 200ml push - should I keep it?

Postby beach sunrise » Sun May 02, 2021 9:50 pm

I have read the type of MJ for best benefit is sativa.
8/19 RC CEA 82.6 T3N0M0
5FU/rad 6 wk
IVC 75g 1 1/2 wks before surgery. Continue 2x a week
Surg 1/20 -margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24 post 5.9
FOLFOX
7 rds 6-10 CEA 11.4 No more
CEA
7/20 11.1 8.8
8/20 7.8
9/20 8.8, 9, 8.6
10/20 8.1
11/20 8s
12/20 8s-9s
ADAPT++++ chrono
CEA
10/23/22 26.x
12/23/22 22.x
2023
1/5 17.1
1/20 15.9
3/30 14.9
6/12 13.3
8/1 2.1
Nodule RML SUV 1.3 5mm
Rolles 3 of 4 lung nodules cancer
KRAS
Chem-sens test failed Not enough ca cells to test

CancerBum21
Posts: 29
Joined: Fri Feb 26, 2021 6:27 am

Re: 5-fu 200ml push - should I keep it?

Postby CancerBum21 » Mon May 03, 2021 12:25 pm

@zephyr Thanks, that makes sense. I'll have to try the ReliefBand too.

zephyr wrote:I don't think you will get the same effect from CBD alone but all you probably need is a touch of THC.
34/M
DX:(Rectal Cancer) 2/15/21
Stage: T1N0M0
TAMIS Surgery 3/10/21
Pathology: T1NxM0 - LIV positive, 1/1 lymph positive Stage IIIA
FOLFOX 6 rounds
Radation & Xelota 5 weeks

CancerBum21
Posts: 29
Joined: Fri Feb 26, 2021 6:27 am

Re: 5-fu 200ml push - should I keep it?

Postby CancerBum21 » Thu May 13, 2021 3:27 pm

We ended up dropping the 5-fu push or Bulus as my doctor refers to it. My liver wasn’t doing so hot so they thought it best to pump the breaks. I guess there is some research showing the bulus dosent impact efficacy of the treatment. I haven’t had time to read it but I guess Emory did a study some years ago.

I’m feeling way way better from a nasuea stand point 3 days post chemo. Combination of Emen, colase, and taking zofran on a schedule has really helped.
34/M
DX:(Rectal Cancer) 2/15/21
Stage: T1N0M0
TAMIS Surgery 3/10/21
Pathology: T1NxM0 - LIV positive, 1/1 lymph positive Stage IIIA
FOLFOX 6 rounds
Radation & Xelota 5 weeks

boxhill
Posts: 789
Joined: Fri Apr 06, 2018 11:40 am

Re: 5-fu 200ml push - should I keep it?

Postby boxhill » Fri May 14, 2021 11:40 am

My infusion center gave me a sustol shot the first time and emend thereafter as a longer-acting premed--sustol injection gave me a large, nasty bump that persisted--and I was never actually nauseous, although my stomach felt a bit off sometimes on the third day. I was given ondansetron and zofran (IIRC) to have on hand.

From what I've read here some infusion centers seem to take a less aggressive approach to nausea prevention; for example, only adding emend if you are actually sick. Seems like a mistake to me. Nausea tends to breed nausea.

I had the push throughout, although the total dose was lowered eventually because of low blood counts.
F, 64 at DX CRC Stage IV
3/17/18 blockage, r hemi
11 of 25 LN,5 mesentery nodes
5mm liver met
pT3 pN2b pM1
BRAF wild, KRAS G12D
dMMR, MSI-H
5/18 FOLFOX
7/18 and 11/18 CT NED
12/18 MRI 5mm liver mass, 2 LNs in porta hepatis
12/31/18 Keytruda
6/19 Multiphasic CT LNs normal, Liver stable
6/28/19 Pause Key, predisone for joint pain
7/31/19 Restart Key
9/19 CT stable
Pain: all fails but Celebrex
12/23/19 CT stable
5/20 MRI stable/NED
6/20 Stop Key
All MRIs NED


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