List of chemo drugs approved for colorectal cancer (2021)

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O Stoma Mia
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List of chemo drugs approved for colorectal cancer (2021)

Postby O Stoma Mia » Mon Mar 01, 2021 4:36 am

For reference, here are the main chemo drugs and chemo drug-combinations in use right now, along with their dates of original FDA approval :

    Drugs used in colorectal cancer
    1962 5-FU (Fluorouracil Injection) - no restrictions
    1998 Xeloda (Capecitabine) - no restrictions
    2000 Camptosar (Irinotecan Hydrochloride) - no restrictions
    2004 Avastin (Bevacizumab) - mCRC 1st line+
    2004 Eloxatin (Oxaliplatin) - no restrictions
    2004 Erbitux (Cetuximab) - mCRC 1st line+, KRAS wild type only
    2006 Vectibix (Panitumumab) - mCRC 1st line+, KRAS wild type only
    2012 Keytruda (Pembrolizumab) - mCRC 1st line, MSI-H only
    2012 Zaltrap (Ziv-Aflibercept) - mCRC 2nd line,
    2012 Stivarga (Regorafenib) - no restrictions
    2014 Cyramza (Ramucirumab) - mCRC 2nd line
    2015 Lonsurf (Trifluridine and Tipiracil Hydrochloride) - no restrictions
    2017 Opdivo (Nivolumab) - mCRC 1st line+, MSI-H only
    2018 Yervoy (Ipilimumab) - mCRC 1st line+, MSI-H only
    2019 Zirabev (Bevacizumab.alt) - mCRC 1st line+
    2020 Braftovi (Encorafenib) - mCRC, BRAF V600E only

    Drug Combinations Used in Rectal Cancer
    FOLFIRI
    FOLFOXIRI
    FOLFOXIRI+AVASTIN
    FOLFIRI+AVASTIN
    FOLFIRI+ERBITUX
    FOLFIRI+VECTIBIX
    FOLFOX
    FOLFOX+AVASTIN
    5FU+LV
    XELIRI
    XELOX(CAPEOX)
==================================
FDA-Approved Colorectal Cancer Treatments (2020)
https://www.empr.com/wp-content/uploads/sites/7/2020/08/FDA-Approved-Colorectal-Cancer-Treatments-0820.pdf
Last edited by O Stoma Mia on Sun Oct 24, 2021 12:04 am, edited 2 times in total.

Rock_Robster
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Joined: Thu Oct 25, 2018 5:27 am
Location: Brisbane, Australia

Re: List of chemo drugs approved for colorectal cancer (2021)

Postby Rock_Robster » Sat Oct 23, 2021 5:06 am

I might well be wrong here, but am I right in thinking the triplet protocol for CRC would be FOLFOXIRI, not FOLFIRINOX? Although the drugs are the same, the protocol dosages/frequencies are different, and I believe FOLFIRINOX is mainly used for pancreatic cancer.
41M Australia
2018 Dx RC
G2 EMVI LVI, 4 liver mets
pT3N1aM1a Stage IVa MSS NRAS G13R
CEA 14>2>32>16>19>30>140>70
11/18 FOLFOX
3/19 Liver resection
5/19 Pelvic IMRT
7/19 ULAR
8/19 Liver met
8/19 FOLFOX, FOLFOXIRI, FOLFIRI
12/19 Liver resection
NED 2 years
11/21 Liver met, PALN, lung nodules
3/22 PVE, lymphadenectomy, liver SBRT
10/22 PALN SBRT
11/22 Liver mets, peri nodule. Xeloda+Bev
4/23 XELIRI+Bev
9/23 ATRIUM trial
12/23 Modified FOLFIRI+Bev

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O Stoma Mia
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Re: List of chemo drugs approved for colorectal cancer (2021)

Postby O Stoma Mia » Sat Oct 23, 2021 6:14 am

Rock_Robster wrote:I might well be wrong here, but am I right in thinking the triplet protocol for CRC would be FOLFOXIRI, not FOLFIRINOX? Although the drugs are the same, the protocol dosages/frequencies are different, and I believe FOLFIRINOX is mainly used for pancreatic cancer.

Rock_Robster -

Thanks for the heads up. I think you're right, based on what is said in this 2020 article:
FOLFIRINOX regimen is the first-line reference chemotherapy (L1) in advanced pancreatic ductal adenocarcinoma (aPDAC). FOLFOXIRI, a schedule with a lower dose of irinotecan and no bolus 5-fluorouracil, has demonstrated efficacy and feasibility in colorectal cancer.

 FOLFOXIRI vs FOLFIRINOX as first-line chemotherapy in patients with advanced pancreatic cancer: A population-based cohort study.
Reference: https://www.wjgnet.com/1948-5204/full/v12/i3/332.htm

World J Gastrointest Oncol 2020; 12(3): 332-346


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