List of chemo drugs approved for colorectal cancer (2021)

Please feel free to read, share your thoughts, your stories and connect with others!
User avatar
O Stoma Mia
Posts: 1691
Joined: Sat Jun 22, 2013 6:29 am

List of chemo drugs approved for colorectal cancer (2021)

Postby O Stoma Mia » Mon Mar 01, 2021 4:36 am

For reference, here are the main chemo drugs and chemo drug-combinations in use right now, along with their dates of original FDA approval :

    Drugs used in colorectal cancer
    1962 5-FU (Fluorouracil Injection) - no restrictions
    1998 Xeloda (Capecitabine) - no restrictions
    2000 Camptosar (Irinotecan Hydrochloride) - no restrictions
    2004 Avastin (Bevacizumab) - mCRC 1st line+
    2004 Eloxatin (Oxaliplatin) - no restrictions
    2004 Erbitux (Cetuximab) - mCRC 1st line+, KRAS wild type only
    2006 Vectibix (Panitumumab) - mCRC 1st line+, KRAS wild type only
    2012 Keytruda (Pembrolizumab) - mCRC 1st line, MSI-H only
    2012 Zaltrap (Ziv-Aflibercept) - mCRC 2nd line,
    2012 Stivarga (Regorafenib) - no restrictions
    2014 Cyramza (Ramucirumab) - mCRC 2nd line
    2015 Lonsurf (Trifluridine and Tipiracil Hydrochloride) - no restrictions
    2017 Opdivo (Nivolumab) - mCRC 1st line+, MSI-H only
    2018 Yervoy (Ipilimumab) - mCRC 1st line+, MSI-H only
    2019 Zirabev (Bevacizumab.alt) - mCRC 1st line+
    2020 Braftovi (Encorafenib) - mCRC, BRAF V600E only

    Drug Combinations Used in Rectal Cancer
    FOLFIRI
    FOLFOXIRI
    FOLFOXIRI+AVASTIN
    FOLFIRI+AVASTIN
    FOLFIRI+ERBITUX
    FOLFIRI+VECTIBIX
    FOLFOX
    FOLFOX+AVASTIN
    5FU+LV
    XELIRI
    XELOX(CAPEOX)
==================================
FDA-Approved Colorectal Cancer Treatments (2020)
https://www.empr.com/wp-content/uploads/sites/7/2020/08/FDA-Approved-Colorectal-Cancer-Treatments-0820.pdf
Last edited by O Stoma Mia on Sun Oct 24, 2021 12:04 am, edited 2 times in total.

Rock_Robster
Posts: 591
Joined: Thu Oct 25, 2018 5:27 am
Location: Brisbane, Australia

Re: List of chemo drugs approved for colorectal cancer (2021)

Postby Rock_Robster » Sat Oct 23, 2021 5:06 am

I might well be wrong here, but am I right in thinking the triplet protocol for CRC would be FOLFOXIRI, not FOLFIRINOX? Although the drugs are the same, the protocol dosages/frequencies are different, and I believe FOLFIRINOX is mainly used for pancreatic cancer.
39M Australia
2018 Dx RC, 12cm high
Mod diff, EMVI+ LVI+. 4 liver mets
pT3N1aM1a Stage IVa. MSS NRAS G13R
CEA: Nov-18= 14, Mar-19= 2.4, Aug-19 <2.0, Mar-20=2.2, May-20=1.9, Jun-20=2.1, Sep-20: 2.1, Dec-20: 2.3, Mar-21=2.5, Jul-21=3.1
11/18 FOLFOX x6
3/19 Liver resection
5/19 25x pelvic radiation; complete met. response
07/19 ULAR w ileo, 1/27 LN+
08/19 Found liver spot
08/19 FOLFOX x1, FOLFOXIRI x1, FOLFIRI x5
12/19 Liver resection
02/20 Ileo reversed
03/20 NED (CT/PET/MRI/scope) - latest scans Jul-21

User avatar
O Stoma Mia
Posts: 1691
Joined: Sat Jun 22, 2013 6:29 am

Re: List of chemo drugs approved for colorectal cancer (2021)

Postby O Stoma Mia » Sat Oct 23, 2021 6:14 am

Rock_Robster wrote:I might well be wrong here, but am I right in thinking the triplet protocol for CRC would be FOLFOXIRI, not FOLFIRINOX? Although the drugs are the same, the protocol dosages/frequencies are different, and I believe FOLFIRINOX is mainly used for pancreatic cancer.

Rock_Robster -

Thanks for the heads up. I think you're right, based on what is said in this 2020 article:
FOLFIRINOX regimen is the first-line reference chemotherapy (L1) in advanced pancreatic ductal adenocarcinoma (aPDAC). FOLFOXIRI, a schedule with a lower dose of irinotecan and no bolus 5-fluorouracil, has demonstrated efficacy and feasibility in colorectal cancer.

 FOLFOXIRI vs FOLFIRINOX as first-line chemotherapy in patients with advanced pancreatic cancer: A population-based cohort study.
Reference: https://www.wjgnet.com/1948-5204/full/v12/i3/332.htm

World J Gastrointest Oncol 2020; 12(3): 332-346


Return to “Colon Talk - Colon cancer (colorectal cancer) support forum”



Who is online

Users browsing this forum: No registered users and 40 guests