List of chemo drugs approved for colorectal cancer (2021)

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O Stoma Mia
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List of chemo drugs approved for colorectal cancer (2021)

Postby O Stoma Mia » Mon Mar 01, 2021 4:36 am

For reference, here are the main chemo drugs and chemo drug-combinations in use right now, along with their dates of original FDA approval :

    Drugs used in colorectal cancer
    1962 5-FU (Fluorouracil Injection) - no restrictions
    1998 Xeloda (Capecitabine) - no restrictions
    2000 Camptosar (Irinotecan Hydrochloride) - no restrictions
    2004 Avastin (Bevacizumab) - mCRC 1st line+
    2004 Eloxatin (Oxaliplatin) - no restrictions
    2004 Erbitux (Cetuximab) - mCRC 1st line+, KRAS wild type only
    2006 Vectibix (Panitumumab) - mCRC 1st line+, KRAS wild type only
    2012 Keytruda (Pembrolizumab) - mCRC 1st line, MSI-H only
    2012 Zaltrap (Ziv-Aflibercept) - mCRC 2nd line,
    2012 Stivarga (Regorafenib) - no restrictions
    2014 Cyramza (Ramucirumab) - mCRC 2nd line
    2015 Lonsurf (Trifluridine and Tipiracil Hydrochloride) - no restrictions
    2017 Opdivo (Nivolumab) - mCRC 1st line+, MSI-H only
    2018 Yervoy (Ipilimumab) - mCRC 1st line+, MSI-H only
    2019 Zirabev (Bevacizumab.alt) - mCRC 1st line+
    2020 Braftovi (Encorafenib) - mCRC, BRAF V600E only

    Drug Combinations Used in Rectal Cancer
    FOLFIRI
    FOLFIRINOX
    FOLFIRINOX+AVASTIN
    FOLFIRI+AVASTIN
    FOLFIRI+ERBITUX
    FOLFIRI+VECTIBIX
    FOLFOX
    FOLFOX+AVASTIN
    5FU+LV
    XELIRI
    XELOX(CAPEOX)

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