saltygirl wrote:I am stage 4. My test was also negative. Not sure what it means for the future. I did have full pathological response to chemo before surgery. Surgery found 0 cancer cells. Now I am finishing my post surgery chemo. My test in Jan was negative.
Sunnycd wrote:I am also wondering....Why isn’t this test offered before you undergo preventative chemo? I had a surgery that supposedly took the tumors out, and I am currently undergoing CAPOX “just in case” there are any wandering cancer cells. Well, why is the test being offered while I am in the middle of chemo. If I had taken it before, and there were no lingering cancer cells, it would have saved me from having to do chemo? I am confused as to why the doctors say it is data that can’t be acted upon, when it seems that it could have been acted upon if tested at the right time?
Objective 3. Evaluate survival in patients treated with adjuvant versus no adjuvant chemotherapy in patients with SIGNATERA™ negative test results [Time Frame: 2 years]
Proportion of patients with a negative SIGNATERA™ ctDNA test post-surgery that are still alive the end of the trial (during surveillance) treated with adjuvant versus no adjuvant chemotherapy
...Once ctDNA technology evolves to fulfill this promise, several important objectives will be achieved: First, adjuvant chemotherapy could be withheld in patients with undetectable, post-operative ctDNA, who would ordinarily be considered high risk and receive treatment with adjuvant chemotherapy according to current guidelines...
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