CRC and Comorbidity, Part I: Bibliography

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CRC and Comorbidity, Part I: Bibliography

Postby JJH » Sat Feb 20, 2021 2:33 pm

  1. What Is Comorbidity? When a Person Has More Than One Condition.
    Sherry Christiansen
  2. Magnitude of the Age-Advancement Effect of Comorbidities in Colorectal Cancer Prognosis.
    Daniel Boakye MPH, et al.
    Journal of the National Comprehensive Cancer Care Network
  3. The impact of comorbidities on post-operative complications following colorectal cancer surgery.
    David E. Flynn, et al.
    PLoS ONE
  4. Comorbidity network analysis and genetics of colorectal cancer.
    Branimir Ljubica et al.
    Informatics in Medicine Unlocked
  5. Epidemiology of Colorectal Cancer Comorbidities and Stage at Diagnosis, Survival, and Second Primary Malignancies in Kentucky, 2003-2016.
    Nikita Leigh Vundi
    University of Kentucky - Theses and Dissertations
  6. Comorbidity prevalence among cancer patients: a population-based cohort study of four cancers.
    Helen Fowler, et al.
    BMC Cancer
  7. The effects of comorbidity on colorectal cancer mortality in an Australian cancer population.
    Maleshwane Lettie Pule, et al.
    Scientific Reports
  8. Contrasting effects of comorbidities on emergency colon cancer diagnosis: a longitudinal data-linkage study in England.
    Cristina Renzi et al.
    BMC Health Services Research
  9. The effect of comorbidities on outcomes in colorectal cancer survivors: a population-based cohort study.
    Colleen A Cuthbert, et al.
    Journal of Cancer Survivivorship
  10. Pattern of Comorbidities among Colorectal Cancer Patients in Spain.
    Miguel Angel Luque-Fernandez et al.
    University of Granada
  11. Impact of age and comorbidity on survival in colorectal cancer.
    Elmer E. van Eeghen,et al.
    Journal of Gastrointestinal Oncology
  12. Comorbidity and survival of Danish patients with colon and rectal cancer from 2000–2011: a population-based cohort study.
    Eva Bjerre Ostenfeld et al.
    Clinical Epidemiology
  13. Does comorbidity interact with colorectal cancer to increase mortality? A nationwide population-based cohort study.
    Rune Erichsen, et al.
    British Journal of Cancer
  14. Increasing prevalence of comorbidity in patients with colorectal cancer in the South of the Netherlands 1995–2010.
    N.J. van Leersum, et al.
    International Journal of Cancer
  15. Impact of comorbidity and healthcare utilization on colorectal cancer stage at diagnosis: literature review.
    Mark Corkum et al.
    Cancer Causes Control
  16. Comorbidities Alone Do Not Explain the Undertreatment of Colorectal Cancer in Older Adults: A French Population‐Based Study.
    Valérie Quipourt MD, et al.
    J. American Geriatrics Society
    https://agsjournals.onlinelibrary.wiley ... 11.03334.x
  17. Comorbidity, age, race and stage at diagnosis in colorectal cancer: a retrospective, parallel analysis of two health systems.
    S Yousuf Zafar, et al.
    BMC Cancer
  18. The effect of comorbidity on the use of adjuvant chemotherapy and survival from colon cancer: a retrospective cohort study.
    Diana Sarfati et al.
    BMC Cancer
  19. Does the timing of comorbidity affect colorectal cancer survival? A population based study.
    Lorraine G Shack, et al.
    Postgraduate Medical Journal
  20. Poverty, comorbidity, and survival of colorectal cancer patients diagnosed in Connecticut.
    A P Polednak
    Journal of Health Care for the Poor and Underserved
  21. Comorbidity and colorectal cancer according to subsite and stage: a population-based study.
    M F De Marco et al.
    European Journal of Cancer
"The darkest hour is just before the dawn" - Thomas Fuller (1650)

Posts: 397
Joined: Mon Apr 24, 2017 7:26 am

Re: CRC and Comorbidity, Part I: Bibliography

Postby JJH » Fri Jan 21, 2022 1:46 am


Does anyone here have any thoughts or insights about the relationship between colorectal cancer and comorbidity?
"The darkest hour is just before the dawn" - Thomas Fuller (1650)

Posts: 165
Joined: Sun May 02, 2021 5:52 pm
Location: Massachusetts

Re: CRC and Comorbidity, Part I: Bibliography

Postby MadMed » Fri Jan 21, 2022 12:14 pm

Not sure what you are asking JJH, you posted a lot of data that seems to show correlation between comorbidities and bad or worse prognosis. I think that is rational, maybe not only due to being in poor health to begin with and maybe the treatment not being as aggressive as possible. For example, i was told point blank by my onc that I was getting FOLFIRINOX because i was younger and in good overall health. She said she would not prescribe it if I had other issues than the cancer or was older.
Maybe I am missing what you're asking.
52M DX: RC lower rectum, guessing now 2cm from AV 4/27/2021
T3N0M0 adenocarcinoma with signet ring cell features
Tumor size 30mm
Tumor grade: G3
Baseline CEA 1.0
MSI status: MSS pMMR
Started Folfox 5/12/2021
Switched to FOLFIRINOX from session 2. 8 rounds total.
CT+MRI tumor contained shrunk 80%, no spread to other organs.
CRT started xeloda + 28 days Radiation 9/27-11/04
NED as of 4/06 CT/MRI/sigmoidoscopy
On W&W 04/06/2022

Posts: 365
Joined: Sun Jun 28, 2020 4:44 pm

Re: CRC and Comorbidity, Part I: Bibliography

Postby prayingforccr » Sat Jan 22, 2022 7:44 am

I had hypertension controlled with atenolol prior to diagnosis.
11/19: colonoscopy
12/19: diagnosed with stage 3 rectal cancer 6+cm tumor
1-3/20: 20 sessions of radiation, mon-fri capecetibine+clinical trial drug m3814
7/20: 8 treatmentsFOLFOX
11/20: Primary tumor had complete response.
5/21: Multiple lung nodules (3-6mm) on ct scan
10/21: md anderson gives me 1 year without treatment/3 years with folfiri/avastin (refused)
3/22 No growth in nodules 6 months
8/22 beginning sbrt and immunotherapy
10/22 TIL Therapy

Posts: 698
Joined: Tue Mar 12, 2019 2:41 pm
Location: Montana

Re: CRC and Comorbidity, Part I: Bibliography

Postby Claudine » Mon Jan 24, 2022 3:40 pm

I would say that since my husband had Crohn's disease as a teenager and young adult, he was probably at higher risk of developing CRC (from what I've read).
Wife of Dx 04/18 (51 yo). MSS, KRAS G12A, no primary
Lytic met L4 vertebrae, EBRT 04/18, SBRT 02/19
Resect small intestine 05/18 (no cancer - Crohn's)
Failed adjuvant Xelox ; Folfiri + Avastin 03/19 to 01/20
6.7 cm left adrenal mass 03/19, successful resection 02/20
Multiple small lung nodules (03/19) now gone/calcified
L3-L4-L5 fusion surgery and partial corpectomy 05/20
CEA since 03/19: high 81.1, low 3.2, now 66
MRI 2/11/22: rectal adenocarcinoma pT3 pN0 stage 2A
LAR surgery April 11

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