CRC and Comorbidity, Part I: Bibliography

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JJH
Posts: 352
Joined: Mon Apr 24, 2017 7:26 am

CRC and Comorbidity, Part I: Bibliography

Postby JJH » Sat Feb 20, 2021 2:33 pm

  1. What Is Comorbidity? When a Person Has More Than One Condition.
    Sherry Christiansen
    (2021)
    https://www.verywellhealth.com/comorbidity-5081615#examples-of-comorbidities
    ====
  2. Magnitude of the Age-Advancement Effect of Comorbidities in Colorectal Cancer Prognosis.
    Daniel Boakye MPH, et al.
    Journal of the National Comprehensive Cancer Care Network
    (2020)
    https://jnccn.org/view/journals/jnccn/18/1/article-p59.xml
    ====
  3. The impact of comorbidities on post-operative complications following colorectal cancer surgery.
    David E. Flynn, et al.
    PLoS ONE
    (2020)
    https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0243995
    ====
  4. Comorbidity network analysis and genetics of colorectal cancer.
    Branimir Ljubica et al.
    Informatics in Medicine Unlocked
    (2020)
    https://www.sciencedirect.com/science/article/pii/S2352914820306432
    ====
  5. Epidemiology of Colorectal Cancer Comorbidities and Stage at Diagnosis, Survival, and Second Primary Malignancies in Kentucky, 2003-2016.
    Nikita Leigh Vundi
    University of Kentucky - Theses and Dissertations
    (2020)
    https://uknowledge.uky.edu/cph_etds/271/
    ====
  6. Comorbidity prevalence among cancer patients: a population-based cohort study of four cancers.
    Helen Fowler, et al.
    BMC Cancer
    (2020)
    https://bmccancer.biomedcentral.com/articles/10.1186/s12885-019-6472-9
    ====
  7. The effects of comorbidity on colorectal cancer mortality in an Australian cancer population.
    Maleshwane Lettie Pule, et al.
    Scientific Reports
    (2019)
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561932/
    ====
  8. Contrasting effects of comorbidities on emergency colon cancer diagnosis: a longitudinal data-linkage study in England.
    Cristina Renzi et al.
    BMC Health Services Research
    (2019)
    https://bmchealthservres.biomedcentral.com/track/pdf/10.1186/s12913-019-4075-4.pdf
    ====
  9. The effect of comorbidities on outcomes in colorectal cancer survivors: a population-based cohort study.
    Colleen A Cuthbert, et al.
    Journal of Cancer Survivivorship
    (2018)
    https://pubmed.ncbi.nlm.nih.gov/30191524/
    ====
  10. Pattern of Comorbidities among Colorectal Cancer Patients in Spain.
    Miguel Angel Luque-Fernandez et al.
    University of Granada
    (2018)
    https://www.encr.eu/sites/default/files/2018-ENCR-Conference/MALUQUE_ENCR18_CoMCoR.pdf
    ====
  11. Impact of age and comorbidity on survival in colorectal cancer.
    Elmer E. van Eeghen,et al.
    Journal of Gastrointestinal Oncology
    (2015)
    https://jgo.amegroups.com/article/view/5200/html
    ====
  12. Comorbidity and survival of Danish patients with colon and rectal cancer from 2000–2011: a population-based cohort study.
    Eva Bjerre Ostenfeld et al.
    Clinical Epidemiology
    (2013)
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820479
    ====
  13. Does comorbidity interact with colorectal cancer to increase mortality? A nationwide population-based cohort study.
    Rune Erichsen, et al.
    British Journal of Cancer
    (2013)
    https://www.researchgate.net/publication/256489677_Does_comorbidity_interact_with_colorectal_cancer_to_increase_mortality_A_nationwide_population-based_cohort_study
    ====
  14. Increasing prevalence of comorbidity in patients with colorectal cancer in the South of the Netherlands 1995–2010.
    N.J. van Leersum, et al.
    International Journal of Cancer
    (2012)
    https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.27871
    ====
  15. Impact of comorbidity and healthcare utilization on colorectal cancer stage at diagnosis: literature review.
    Mark Corkum et al.
    Cancer Causes Control
    (2012)
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747100/
    .....
  16. Comorbidities Alone Do Not Explain the Undertreatment of Colorectal Cancer in Older Adults: A French Population‐Based Study.
    Valérie Quipourt MD, et al.
    J. American Geriatrics Society
    (2011)
    https://agsjournals.onlinelibrary.wiley ... 11.03334.x
    ====
  17. Comorbidity, age, race and stage at diagnosis in colorectal cancer: a retrospective, parallel analysis of two health systems.
    S Yousuf Zafar, et al.
    BMC Cancer
    (2008)
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613913/
    ====
  18. The effect of comorbidity on the use of adjuvant chemotherapy and survival from colon cancer: a retrospective cohort study.
    Diana Sarfati et al.
    BMC Cancer
    (2009)
    https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-9-116/
    ====
  19. Does the timing of comorbidity affect colorectal cancer survival? A population based study.
    Lorraine G Shack, et al.
    Postgraduate Medical Journal
    (2009)
    https://pmj.bmj.com/content/86/1012/73
    ====
  20. Poverty, comorbidity, and survival of colorectal cancer patients diagnosed in Connecticut.
    A P Polednak
    Journal of Health Care for the Poor and Underserved
    (2001)
    https://pubmed.ncbi.nlm.nih.gov/11475548/
    ====
  21. Comorbidity and colorectal cancer according to subsite and stage: a population-based study.
    M F De Marco et al.
    European Journal of Cancer
    (2000)
    https://pubmed.ncbi.nlm.nih.gov/10741301/
"The darkest hour is just before the dawn" - Thomas Fuller (1650)

JJH
Posts: 352
Joined: Mon Apr 24, 2017 7:26 am

Re: CRC and Comorbidity, Part I: Bibliography

Postby JJH » Fri Jan 21, 2022 1:46 am

BUMP

Does anyone here have any thoughts or insights about the relationship between colorectal cancer and comorbidity?
"The darkest hour is just before the dawn" - Thomas Fuller (1650)

MadMed
Posts: 82
Joined: Sun May 02, 2021 5:52 pm
Location: Massachusetts

Re: CRC and Comorbidity, Part I: Bibliography

Postby MadMed » Fri Jan 21, 2022 12:14 pm

Not sure what you are asking JJH, you posted a lot of data that seems to show correlation between comorbidities and bad or worse prognosis. I think that is rational, maybe not only due to being in poor health to begin with and maybe the treatment not being as aggressive as possible. For example, i was told point blank by my onc that I was getting FOLFIRINOX because i was younger and in good overall health. She said she would not prescribe it if I had other issues than the cancer or was older.
Maybe I am missing what you're asking.
52M DX: RC lower rectum, guessing now 2cm from AV 4/27/2021
T3N0M0 adenocarcinoma with signet ring cell features
Tumor size 30mm
Tumor grade: G3
Baseline CEA 1.0
MSI status: MSS pMMR
Started Folfox 5/12/2021
Switched to FOLFIRINOX from session 2. 8 rounds total.
CT+MRI tumor contained shrunk 80%, no spread to other organs.
CRT started xeloda + 28 days Radiation 9/27-11/04
surgery postponed until after 2/23 sigmoidoscopy

prayingforccr
Posts: 216
Joined: Sun Jun 28, 2020 4:44 pm

Re: CRC and Comorbidity, Part I: Bibliography

Postby prayingforccr » Sat Jan 22, 2022 7:44 am

I had hypertension controlled with atenolol prior to diagnosis.
11/19: colonoscopy
12/19: diagnosed with stage 3 rectal cancer 6+cm tumor
1-3/20: 20 sessions of radiation, mon-fri capecetibine+clinical trial drug m3814
7/20: 8 treatmentsFOLFOX
11/20: Primary tumor had complete response. Possible tumor deposits on latest mri. Biopsy negative for cancer.
5/21: Multiple lung nodules (3-6mm) on ct scan
10/21: md anderson gives me 1 year without treatment/3 years with folfiri/avastin (refused)
3/22 Will begin immunotherapy/sbrt at weill cornell and nyu/langone in march

Claudine
Posts: 588
Joined: Tue Mar 12, 2019 2:41 pm
Location: Montana

Re: CRC and Comorbidity, Part I: Bibliography

Postby Claudine » Mon Jan 24, 2022 3:40 pm

I would say that since my husband had Crohn's disease as a teenager and young adult, he was probably at higher risk of developing CRC (from what I've read).
Wife of Dx 04/18 (51 yo). MSS, KRAS G12A
No primary (involuted?)
Lytic tumor L4 vertebrae, EBRT 04/18, SBRT 02/19
Resect small intestine 05/18 (no cancer - Crohn's)
Failed adjuvant Xelox
Folfiri + Avastin 03/19 to 01/20
6.7 cm left adrenal mass 03/19, successful resection 02/20
CEA since 03/19: high 81.1, low 3.2, now 51
Scan 03/19: Multiple small lung nodules, now gone/calcified
L3-L4-L5 fusion surgery and partial corpectomy 05/20
Colonoscopy 01/18/22: flat tumor (4cm) mid rectum


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