FGFR1 amplification and EGFR amplification

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Joined: Fri Apr 11, 2014 12:04 pm

FGFR1 amplification and EGFR amplification

Postby boswind » Sun Jan 31, 2021 4:52 pm

Hi All,

Long time no see. Amazingly my disease is still kind of "stable". Recently, I had a liquid biopsy done, showing
FGFR1 amplification (medium) and
EGFR amplification (low).

My oncologist is thinking that after my current treatment fails, he would use an off-label medicine targeting at FGFR1 amplification. Currently there are 6 medicines approved for anti-FGFR1 amplification; none of them is for colon cancer. But he honestly says none of them would work since I already used regorafenib and failed.

Also now I am saying to him that we may try Cetuximab+ Irinotecan for EGFR amplification. But he does not think it would work.

I would appreciate your comments

01.24.14 Male, DX @54 Rectosigmoid Cancer, MRI: T3N0M0
03.19.14 Completed 5-week Radia+Xeloda
05.07.14 Had surgery
02.25.15 CT showed stage 4 inoperable
03.15 - 08.15, folfox + Avastin
08.15 - 07.17, 5FU+leucovorin+Avastin
07.17 - 01.18, Folfuri + Avastin
02.18 - 03.19, Centuximab + Irinotecan
03.19 - 05.19, Keytruda
05.19 - 9.19, Folfox+Avastin
10.19 -01.20: Centuximab+Irinotecan
03.20 - 06.20: STIVARGA
07.20 - present: lonsurf+Avanstin
131 rounds of chemos received (as of 12.31.20)

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