Covid 19 vaccine

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NHMike
Posts: 2542
Joined: Fri Jul 21, 2017 3:43 am

Re: Covid 19 vaccine

Postby NHMike » Fri Mar 05, 2021 9:03 pm

boxhill wrote:Glad to hear that SOMEONE is getting vaccinated! They're still working on people 70+ only here in Maine.


In NH, those over 65 are getting vaccinations. Our vaccine supply has tripled this week though.

I'm in the 50-65 category and we can start making resrvations March 22 for vaccinations starting March 25. I have no doubt that actually getting one will probably be more like late April or May as I expect to see an absolute crush for the online reservation system.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8, 2/12 1.2
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal
2/19: Clean CT

boxhill
Posts: 730
Joined: Fri Apr 06, 2018 11:40 am

Re: Covid 19 vaccine

Postby boxhill » Mon Mar 08, 2021 11:28 am

Last week they opened up vaccination to the 60+ age group in Maine. I was lucky enough to get an appointment on Friday the 5th for the first vaccination. The second one will be on March 26th.
F, 64 at DX CRC Stage IV
3/17/18 blockage, r hemi
11 of 25 LN,5 mesentery nodes
5mm liver met
pT3 pN2b pM1
BRAF wild, KRAS G12D
dMMR, MSI-H
5/18 FOLFOX
7/18 and 11/18 CT NED
12/18 MRI 5mm liver mass, 2 LNs in porta hepatis
12/31/18 Keytruda
6/19 Multiphasic CT LNs normal, Liver stable
6/28/19 Pause Key, predisone for joint pain
7/31/19 Restart Key
9/19 CT stable
Pain: all fails but Celebrex
12/23/19 CT stable
5/19 MRI stable/NED
Stop Key
All MRIs NED

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CRguy
Posts: 10317
Joined: Sun Feb 10, 2008 6:00 pm

Re: Covid 19 vaccine

Postby CRguy » Mon Mar 08, 2021 8:15 pm

Did a brief update in the linked topic regarding early Vax rollout locally in Canada

COVID vaccine rollout for Colorectal CANUCKS !

Gladly all four approved Vaccines are now in the chain.
Caregiver x 4
Stage IV A rectal cancer/lung met
14 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

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mmblz
Posts: 58
Joined: Sat Oct 10, 2015 3:03 pm

Re: Covid 19 vaccine

Postby mmblz » Fri Mar 12, 2021 4:28 am

NHMike wrote:
boxhill wrote:Glad to hear that SOMEONE is getting vaccinated! They're still working on people 70+ only here in Maine.


In NH, those over 65 are getting vaccinations. Our vaccine supply has tripled this week though.

I'm in the 50-65 category and we can start making resrvations March 22 for vaccinations starting March 25. I have no doubt that actually getting one will probably be more like late April or May as I expect to see an absolute crush for the online reservation system.


Hopefully they will be on the NH built system by then? VAMS is a disaster.
40yo married 16 years. 4 kids 12, 10, 7, 5
2015-09-21 colonoscopy finds tumor in sigmoid, partial obstruction
2015-09-22 CT no mets, path G2 adenocarcinoma, CEA 1.2
2015-09-29 lap hemicolectomy at MSKCC
2015-10-06 pT3 N1a M0 stage IIIB
2015-10-22 folfox started - 12 rounds, last 4 no oxaliplatin
2016-10-27 clear CT !
2021-03-25 "cured"

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CRguy
Posts: 10317
Joined: Sun Feb 10, 2008 6:00 pm

Re: Covid 19 vaccine

Postby CRguy » Tue Mar 16, 2021 12:46 pm

stu wrote:So both myself and my sons got the AstraZeneca vaccine. Was surprised to feel quite ill for 24 hours . My parents had the same one and were fine .

Anyway just grateful to have it and there is talk of a third top up in Autumn. The Strain identified in Brazil has arrived in Scotland but contained just now so I think it’s possibly to cover all possibilities.
The good news our infection rate has sharply plummeted from 60000 to 6000 daily ! This is working !
Stu

Just a question for you Stu :

any further discussions where you are, concerning the recent blood clots issue from the AZ vaccine ?
We are hearing it was associated with just one particular vaccine batch and the numbers present as similar to the general population with other vaccines. We are also hearing that seniors here would not get the AZ ... BUTT that apparently has been reversed as of today ????

https://globalnews.ca/news/7698838/astr ... s-seniors/

Glad you all got a vax and are doing well
Cheers and best wishes
CRguy
Caregiver x 4
Stage IV A rectal cancer/lung met
14 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

stu
Posts: 1503
Joined: Sat Aug 17, 2013 5:46 pm

Re: Covid 19 vaccine

Postby stu » Thu Mar 18, 2021 4:13 pm

Hi ,

They have made a statement that it is safe and “ no prove causal link between the blood clots and the vaccine “ . To be fair literally millions of us in the U.K. have had it . The elderly population mostly got AZ as it so much easier for storage in the GP practices as far as I am aware ! Most have had no reaction whatsoever. However now we are getting to younger age groups more are reporting a rough 24 hours . Not sure if there is any science behind it but the it does seem as though the elderly population tolerated it better ! But it might just be the way it’s been reported.
We have administered nearly 26 million so a reasonable sample within that number . Europe have just given the green light to start using it again .

Also delaying the second dose seems to be paying off and the death rate in the 80 plus group from covid has plummeted. Our schools have just started to filter back so I expect a bit of a rise with that but it’s been so encouraging to see the numbers come down .
How is the vaccination program going in Canada ?

take care ,
Stu
supporter to my mum who lives a great life despite a difficult diagnosis
stage4 2009 significant spread to liver
2010 colon /liver resection
chemo following recurrence
73% of liver removed
enjoying life treatment free
2016 lung resection
Oct 2017 nice clear scan . Two lung nodules disappeared
Oct 2018. Another clear scan .

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CRguy
Posts: 10317
Joined: Sun Feb 10, 2008 6:00 pm

Re: Covid 19 vaccine

Postby CRguy » Sat Mar 20, 2021 10:01 pm

stu wrote:Also delaying the second dose seems to be paying off and the death rate in the 80 plus group from covid has plummeted. Our schools have just started to filter back so I expect a bit of a rise with that but it’s been so encouraging to see the numbers come down .
How is the vaccination program going in Canada ?

take care ,
Stu

Glad to see numbers on the decline !!!!

Canada ..... sporadic / protean / political and less intense/ effective than I would have expected :twisted:

BUTT onward we go

Cheers and stay safe
CRguy
Caregiver x 4
Stage IV A rectal cancer/lung met
14 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

NHMike
Posts: 2542
Joined: Fri Jul 21, 2017 3:43 am

Re: Covid 19 vaccine

Postby NHMike » Sat Apr 03, 2021 6:36 pm

NH opened appointments to everyone yesterday. I had to reschedule my second dose because Walgreens screwed up and they don't have second appointments available. I found something but it's not ideal. First dose of Pfizer this past Thursday. My arm was sore Thursday night until Friday afternoon. It was quite annoying as I have Golfer's Elbow in the right arm so I had to consider carefully in picking something up or doing something above my shoulder.

I schedule the second appointment on a day when I have nothing else scheduled for two days in case I wind up with the flu-like symptoms for a day or two.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8, 2/12 1.2
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal
2/19: Clean CT

boxhill
Posts: 730
Joined: Fri Apr 06, 2018 11:40 am

Re: Covid 19 vaccine

Postby boxhill » Sat Apr 10, 2021 2:10 pm

Both my husband and I have had both shots of Pfizer with nothing more troubling that a day's worth of sore upper arm. Same thing for my mother, who is 98. As of yesterday it has been two weeks since my second shot, so I'm good to go, so to speak. :D Feels liberating.
F, 64 at DX CRC Stage IV
3/17/18 blockage, r hemi
11 of 25 LN,5 mesentery nodes
5mm liver met
pT3 pN2b pM1
BRAF wild, KRAS G12D
dMMR, MSI-H
5/18 FOLFOX
7/18 and 11/18 CT NED
12/18 MRI 5mm liver mass, 2 LNs in porta hepatis
12/31/18 Keytruda
6/19 Multiphasic CT LNs normal, Liver stable
6/28/19 Pause Key, predisone for joint pain
7/31/19 Restart Key
9/19 CT stable
Pain: all fails but Celebrex
12/23/19 CT stable
5/19 MRI stable/NED
Stop Key
All MRIs NED

Siti
Posts: 224
Joined: Thu Aug 01, 2019 10:58 am

Re: Covid 19 vaccine

Postby Siti » Thu Jul 22, 2021 8:37 am

Hey everyone,

UPDATE: My husband received the results of his on-going vaccine clinal trial. They took a sample of his blood 1 month post 2nd dose (mRNA Moderna) and the level of his antibodies are good.

According to the letter received, the amount is sufficient to offer good protection. He has about 1.5k BAU/ml.

Convalescent adults usually have a reading (≥ 33.8 BAU/mL). The higher the concentration corresponds to the level of protection which seem to also directly correlate with efficacy of the vaccine.

Since my husband is still on maintenance chemo, the good news is, it doesn’t seem to affect the vaccine’s ability to offer protection. I hope this is encouraging news to all of you too.

I’ll keep everyone posted once he received the results of his next blood test in a few months.

Take care :)

Siti
Wife of DH (54) DX on 5/7/19
Sigmoid | Adenocarcinoma | Grade: G3 | LNs: 30/31
Wild Type for KRAS, NRAS and BRAF
19/7/19 PET-CT Scan: Distant lymph nodes (para-aorta, neck & hip), est. size 0.5-1.5cm.
22/7/19 Surgery: Laparoscopic Colon Resection
26/8/19 Chemo: CAPEOX + Avastin x 7
6/11/19 CT Scan after 3rd cycle, all nodes have shrunk! Yay!! 20/12/19 Last round of Ox (NED)
1/2020 Maintenance: Cap + Avastin
4/2020 Maintenance: switch to Teysuno (S-1) + Avastin due to bad HFS side effects.

User avatar
horizon
Posts: 1621
Joined: Tue Apr 12, 2011 10:10 pm

Re: Covid 19 vaccine

Postby horizon » Thu Jul 22, 2021 8:49 am

Siti wrote:Hey everyone,

UPDATE: My husband received the results of his on-going vaccine clinal trial. They took a sample of his blood 1 month post 2nd dose (mRNA Moderna) and the level of his antibodies are good.

According to the letter received, the amount is sufficient to offer good protection. He has about 1.5k BAU/ml.

Convalescent adults usually have a reading (≥ 33.8 BAU/mL). The higher the concentration corresponds to the level of protection which seem to also directly correlate with efficacy of the vaccine.

Since my husband is still on maintenance chemo, the good news is, it doesn’t seem to affect the vaccine’s ability to offer protection. I hope this is encouraging news to all of you too.

I’ll keep everyone posted once he received the results of his next blood test in a few months.

Take care :)

Siti


Thank you for sharing this. That is really great to hear.
I'm just a dude who still can't believe he had a resection and went through chemo (currently 10 years NED). Is this real life?

roadrunner
Posts: 131
Joined: Sun Jan 12, 2020 8:46 pm

Re: Covid 19 vaccine

Postby roadrunner » Thu Jul 22, 2021 11:00 am

This is great to hear, and I doubt too many folks on here need a note of caution in this area. But perhaps it’ll be useful for someone. With respect to immune response to vaccines, including the wonderful mRNA vaccines, responses are very variable, so one person’s case is mostly relevant for that person, and not applicable to everybody. In this case, while the literature I’ve seen supports expectation of strong vaccine response in solid tumor patients, there are LOTS of variables. For example, antibody level indicators alone may not establish optimal or sufficient protection, protective levels of response may vary with the emergence of new variants (e.g., the currently dominant Delta variant, which is far more infectious than previous versions), will definitely vary by individual, may vary by type and stage of chemo, and may wane over time (or may not). We also won’t always see new, more vaccine-evasive variants until they are at least somewhat dispersed. In other words, this is a hopeful story, but I at least would urge continued caution in a community like this one until and unless vaccination levels increase in the general population (thus reducing community spread to lower levels).
7/19: Rectal cancer: Initially staged as IIIA, T2N1M0
Initially approx 4.25 cm, low/mid rectum, mod. well diff. adenocarcinoma
8/22 -10/14 4 rounds FOLFOX neoadjuvant, 3 w/Oxiplatin (lots of side effects/reduced size est. 70-75%)
neoadjuvant chemorad 11/19
4 rounds of FOLFOX July-August 2020
ncCR found 10/20; multiple biopsies negative
TAE 11/20, small amount of tumor removed, lung nodules orig id’d 6/20 stable Nov 2020
Chest CT 3/30/21 small growth in 2 nodules (3 and 5mm)
Stable in 6/28 scan.

Siti
Posts: 224
Joined: Thu Aug 01, 2019 10:58 am

Re: Covid 19 vaccine

Postby Siti » Fri Jul 23, 2021 5:33 pm

roadrunner wrote:This is great to hear, and I doubt too many folks on here need a note of caution in this area. But perhaps it’ll be useful for someone. With respect to immune response to vaccines, including the wonderful mRNA vaccines, responses are very variable, so one person’s case is mostly relevant for that person, and not applicable to everybody. In this case, while the literature I’ve seen supports expectation of strong vaccine response in solid tumor patients, there are LOTS of variables. For example, antibody level indicators alone may not establish optimal or sufficient protection, protective levels of response may vary with the emergence of new variants (e.g., the currently dominant Delta variant, which is far more infectious than previous versions), will definitely vary by individual, may vary by type and stage of chemo, and may wane over time (or may not). We also won’t always see new, more vaccine-evasive variants until they are at least somewhat dispersed. In other words, this is a hopeful story, but I at least would urge continued caution in a community like this one until and unless vaccination levels increase in the general population (thus reducing community spread to lower levels).


Absolutely. We never took for granted and have not even gone to a indoor restaurant for 1.5 years. My husband still wears a face mask when meeting even fully vaccinated colleagues because it’s the responsible thing to do. Every individual is different, healthy ones included. This study is mainly comparing those undergoing cancer treatment vs healthy adults. There is a cohort whom are undergoing immunotherapy too. The results will be published next year (it’s a 1 year study).
Wife of DH (54) DX on 5/7/19
Sigmoid | Adenocarcinoma | Grade: G3 | LNs: 30/31
Wild Type for KRAS, NRAS and BRAF
19/7/19 PET-CT Scan: Distant lymph nodes (para-aorta, neck & hip), est. size 0.5-1.5cm.
22/7/19 Surgery: Laparoscopic Colon Resection
26/8/19 Chemo: CAPEOX + Avastin x 7
6/11/19 CT Scan after 3rd cycle, all nodes have shrunk! Yay!! 20/12/19 Last round of Ox (NED)
1/2020 Maintenance: Cap + Avastin
4/2020 Maintenance: switch to Teysuno (S-1) + Avastin due to bad HFS side effects.

NHMike
Posts: 2542
Joined: Fri Jul 21, 2017 3:43 am

Re: Covid 19 vaccine

Postby NHMike » Mon Jul 26, 2021 7:24 am

President Biden ordered another 200 million Pfizer vaccine doses to be delivered from Fall to Spring. These are in anticipation of EUA for children under 12 and potentially for booster shots for immunocompromised adults.

Pfizer and Moderna are also working on boosters targeted at the newer variants. It's unfortunate that both are called boosters as they mean different things depending on the context.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8, 2/12 1.2
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal
2/19: Clean CT


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