Stage 3, likelihood of recurrence after resection & chemotherapy

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LivinginHope
Posts: 40
Joined: Sat Oct 31, 2020 4:42 am

Re: Stage 3, likelihood of recurrence after resection & chemotherapy

Postby LivinginHope » Sat Feb 27, 2021 8:32 am

horizon wrote:
I would try not to think of it as "risky". In my opinion not doing the recommended treatment would be risky. He did what was suggested for the best chance for a positive outcome. I was anxious to get some semblance of normalcy back after 6 months of chemo. That's not to say I didn't have big worries when it came time to do scans!



Definitely a better way of looking at it! We’re definitely at that anxious point right now! Only a few more days to go and then he’s done with treatment :) keen for it to finish so he can recover properly but you know the mixed feelings it brings. Dreading the scanxiety already!

Quick question,hope someone will know the answer...from what point are you classed as NED? If his scan/colonoscopy are clear...is he considered NED from that point OR is is the anniversary of the surgery?! We’re a bit confused!
Only thought about it as we are considered a move abroad and you need to be 5yrs NED of Colon cancer. (We’re trying to be optimistic and pray that we’re lucky enough to make it that far)
Husband (36):
- 5/10/20 Rectal CA
- 21/10/20 LAR, 21 nodes removed
- 31/10/20 5/21 positive=Adj Chemo. Surgery=R0
- 11/20 Sperm banked
- 1/12/20 Onc appt: confirmed T3N2M0, regional not distant nodes. Pre-op CEA 2.7/post op 0.7. No mutations. Plan 6m of CAPOX.
- 12/20 Round 1
- 4/1/21 Onc appt: new evidence, 3m is as good as 6m, REDUCED regime to 3m! Round 2. Pre-chemo CEA 0.6
- 25/1/21 Round 3. Pre-chemo CEA 1.1
- 17/2/21 Round 4.
- 2/3/21 Chemo ends
- 07/21 CLEAR CT SCAN & CEA 0.7
-10/21 CEA 1.1

LivinginHope
Posts: 40
Joined: Sat Oct 31, 2020 4:42 am

Re: Stage 3, likelihood of recurrence after resection & chemotherapy

Postby LivinginHope » Sun Jul 04, 2021 1:02 pm

July 2021 UPDATE...

In April, he had a good CEA tracker result of 0.7...which is consistent with his previous results so that was a big relief.

Since finishing chemo we've pretty much gone back to normal, he's back at the gym 3x a week (as he has been since January). Thankfully he's had no lasting side effects of the chemotherapy - we will have to wait until the cold weather returns to see if he gets any neuropathy, but overall we feel really lucky.

Today he has his first post-treatment, surveillance CT scan, so as standard I'm super anxious and he's calm as anything!

We are hoping to start trying for a baby in September :) (6m post chemo as advised) so we are praying nothing holds us back. We are also planning on getting semen analysis done in September too to see if the chemo did do any damage to his swimmers :cry:

So all in all, not much to update, just to say that things a good for now and we pray it continues!
Husband (36):
- 5/10/20 Rectal CA
- 21/10/20 LAR, 21 nodes removed
- 31/10/20 5/21 positive=Adj Chemo. Surgery=R0
- 11/20 Sperm banked
- 1/12/20 Onc appt: confirmed T3N2M0, regional not distant nodes. Pre-op CEA 2.7/post op 0.7. No mutations. Plan 6m of CAPOX.
- 12/20 Round 1
- 4/1/21 Onc appt: new evidence, 3m is as good as 6m, REDUCED regime to 3m! Round 2. Pre-chemo CEA 0.6
- 25/1/21 Round 3. Pre-chemo CEA 1.1
- 17/2/21 Round 4.
- 2/3/21 Chemo ends
- 07/21 CLEAR CT SCAN & CEA 0.7
-10/21 CEA 1.1

Hooandtrue93
Posts: 18
Joined: Tue May 11, 2021 10:28 pm

Re: Stage 3, likelihood of recurrence after resection & chemotherapy

Postby Hooandtrue93 » Mon Jul 05, 2021 2:52 pm

polluxx wrote: I was also staged at 3c and I interpreted what I read online to mean that only 25% of 3c patients were even alive in 5 years. Either way, I like 60% much better.


This always perplexed me. US Seer data and whatnot show Stage IIIc survival around 28% but Canada, for example, shows a survival rate of 52% for stage IIIC and I've talked with other IIIc who have said their doctors said they have a 50% shot of being free 5 year.

Of course at the end of the day, we are a statistic of one. And technology is changing faster than statictics can update
28 year old, son of 62 year old mom
Stage 3B Duodenal Adenocarcinoma.
7/13 lymph nodes positive
02/22/2021: Whipple Surgery
04/08/2021: Port Surgery. CtDNA test sample taken (positive)
04/13/2021: Folfox-6 begins for 6 months
07/16/2021: ctDNA cleared. Continue with 3 more months of adjuvant chemo
09/21/2021: Last cycle of adjuvant chemotherapy.

PainInTheAss
Posts: 673
Joined: Tue Jul 02, 2013 3:08 am

Re: Stage 3, likelihood of recurrence after resection & chemotherapy

Postby PainInTheAss » Sun Jul 11, 2021 2:45 am

Hooandtrue93 wrote:
polluxx wrote: I was also staged at 3c and I interpreted what I read online to mean that only 25% of 3c patients were even alive in 5 years. Either way, I like 60% much better.


This always perplexed me. US Seer data and whatnot show Stage IIIc survival around 28% but Canada, for example, shows a survival rate of 52% for stage IIIC and I've talked with other IIIc who have said their doctors said they have a 50% shot of being free 5 year.

Of course at the end of the day, we are a statistic of one. And technology is changing faster than statictics can update


Yes, this is a very scary thing to see when you are first diagnosed as a IIIc. It's important to remember that SEER is Medicaid/Medicare and that most colon cancer patience are in their 70s. So, you have to think about what that chances are that someone in their 70's will be alive PERIOD in 5 years, whether they have cancer or not.

My oncologist used the stats from their own facility and "younger" patients (people under 70, really) had a much higher percentage than SEER. I was told that doing chemo after surgery would raise my chances of being disease-free (not just alive) after 5 years to 60%. I liked those odds. And here I am, 8 years after diagnosis, disease free.
47yo single mom of 4 (24, 21, 18, 16) at Dx
6/13 - RC T4b IIIc 5LNs on PET CEA 5.4
8/13 - Finish chemorad
10/13 - APR/hyst+ovaries/perm colostomy 2/12 nodes+
6/14 - Finish Xelox 6 rds
1/15 - CT clear CEA 0.2
10/15 - CT/MRI clear CEA 0.7
4/16 - CT clear
10/16 - CT/MRI clear CEA 0.6
5/17 - PET clear? Follow up MRI to verify inflammation

LivinginHope
Posts: 40
Joined: Sat Oct 31, 2020 4:42 am

Re: Stage 3, likelihood of recurrence after resection & chemotherapy

Postby LivinginHope » Fri Aug 06, 2021 12:19 pm

August 2021

First surveillance CT scan was CLEAR :D

A huge relief for us to hear that news! And it felt like the last hurdle before we start trying for a baby in September!

I hope you're all doing well and powering on with your journeys xx
Husband (36):
- 5/10/20 Rectal CA
- 21/10/20 LAR, 21 nodes removed
- 31/10/20 5/21 positive=Adj Chemo. Surgery=R0
- 11/20 Sperm banked
- 1/12/20 Onc appt: confirmed T3N2M0, regional not distant nodes. Pre-op CEA 2.7/post op 0.7. No mutations. Plan 6m of CAPOX.
- 12/20 Round 1
- 4/1/21 Onc appt: new evidence, 3m is as good as 6m, REDUCED regime to 3m! Round 2. Pre-chemo CEA 0.6
- 25/1/21 Round 3. Pre-chemo CEA 1.1
- 17/2/21 Round 4.
- 2/3/21 Chemo ends
- 07/21 CLEAR CT SCAN & CEA 0.7
-10/21 CEA 1.1

vancanes319
Posts: 1
Joined: Wed Sep 01, 2021 1:58 pm

Re: Stage 3, likelihood of recurrence after resection & chemotherapy

Postby vancanes319 » Wed Sep 01, 2021 2:10 pm

Hi, I could not login under my old user name because I do not have access to my old email address.

I was diagnosed in November 2004 at 41 years old with Stage IIIC with 6 nodes positive and a colostomy. I had 12 rounds of Folfox with Oxi. My colostomy was reversed after my chemo was completed.

My four year old son was my driving force. I was told by MSKCC to walk a lot (the first two or three years I walked around 4 miles a day 5/6 times a week, eat a healthy diet, limit red meat and no processed food, take a baby aspirin a day. I'm not sure if the baby aspirin is still advised but I continue to take it.

There is hope always.........

Lots of love and thoughts.

Lori

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O Stoma Mia
Posts: 1691
Joined: Sat Jun 22, 2013 6:29 am
Location: On vacation. Off-line for now.

Re: Stage 3, likelihood of recurrence after resection & chemotherapy

Postby O Stoma Mia » Thu Sep 02, 2021 4:17 pm

vancanes319 wrote:Hi, I could not login under my old user name because I do not have access to my old email address.

I was diagnosed in November 2004 at 41 years old with Stage IIIC with 6 nodes positive and a colostomy. I had 12 rounds of Folfox with Oxi. My colostomy was reversed after my chemo was completed.

My four year old son was my driving force. I was told by MSKCC to walk a lot (the first two or three years I walked around 4 miles a day 5/6 times a week, eat a healthy diet, limit red meat and no processed food, take a baby aspirin a day. I'm not sure if the baby aspirin is still advised but I continue to take it.

There is hope always.........

Lots of love and thoughts.

Lori


Thanks for checking in! Do you realize that you were the 373rd person to ever join this forum? -- And that was a long, long time ago!

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Jimswife
Posts: 907
Joined: Fri Nov 18, 2011 9:53 am

Re: Stage 3, likelihood of recurrence after resection & chemotherapy

Postby Jimswife » Sat Oct 02, 2021 3:08 pm

No recurr here …. Just reaching 10 years x
Victoria , Wife to Jim age 43 dx oct 2011
Stage 3 cc with 2 out of 21 positive lymph nodes
Folfox starts nov 11-may 12
All scans and bloods since surgery confirm no evidence of disease
Hoping to stay ned forever .... Fingers crossed !!!!!!!

LivinginHope
Posts: 40
Joined: Sat Oct 31, 2020 4:42 am

Re: Stage 3, likelihood of recurrence after resection & chemotherapy

Postby LivinginHope » Mon Oct 04, 2021 12:41 pm

Hi there,

Thank you so much for your posts and the reassurance!!

He just had the results from his CEA blood test (take last week)... It's 1.1...so it has risen a bit since the last test. Bit anxious about that. Prior to his surgery it was only 2.7 at its highest, post surgery and during chemo it was around 0.6/0.7 :shock:

He's due a Colonoscopy this month too so praying that's clear.

Hope you're all well.
Husband (36):
- 5/10/20 Rectal CA
- 21/10/20 LAR, 21 nodes removed
- 31/10/20 5/21 positive=Adj Chemo. Surgery=R0
- 11/20 Sperm banked
- 1/12/20 Onc appt: confirmed T3N2M0, regional not distant nodes. Pre-op CEA 2.7/post op 0.7. No mutations. Plan 6m of CAPOX.
- 12/20 Round 1
- 4/1/21 Onc appt: new evidence, 3m is as good as 6m, REDUCED regime to 3m! Round 2. Pre-chemo CEA 0.6
- 25/1/21 Round 3. Pre-chemo CEA 1.1
- 17/2/21 Round 4.
- 2/3/21 Chemo ends
- 07/21 CLEAR CT SCAN & CEA 0.7
-10/21 CEA 1.1

ecretriever6
Posts: 7
Joined: Fri Oct 22, 2021 5:48 pm

Re: Stage 3, likelihood of recurrence after resection & chemotherapy

Postby ecretriever6 » Sat Oct 23, 2021 7:38 am

Hello to all.

I just joined the forum and am pretty scared about this whole thing. My wife was diagnosed in May 2020 and had surgery in June 2020. After surgery, she was diagnosed with Stage 3 CRC. No spread however she had lymph node involvement of 18/37. Did 12 rounds of chemo of 5FU and Oxi. No reductions in the amount. Finished in December 2020 with clear CT scan. Follow up blood work was perfect and had another clear CT scan in July 2021. Also had clear Colonoscopy in April 2021. Most recent CEA has risen from 1.7 to 7. ONC said not to worry but guess what, I am worried. Does this automatically mean she has a recurrence? Just looking for some advice. Also, are there any recent survival statistics or recurrence rates that have been posted? Sorry for the questions but as most people have commented, just worried. Prayers to everyone!!
Diag: 05/20
Surgery: 06/20
Chemo: 07/20 - 12/20
CEA range after chemo: 1.5 - 1.7
LNI: 18/37
Stage: 3c
Clear CT scans 12/20 and 7/21
Wife: 47 at time of DX
Diagnosed: 05/20
Surgery: 06/20
Left Sigmoid
Lymph Nodes: 18/37
Chemo: 07/20 - 12/20 (12 rounds 5fu/oxi)
Clear CT: 12/20, 07/21 (CEA1.2)
CEA pre-surgery: 2
CEA post: 1.2 - 1.9
Stage: 3c
Colonoscopy: 05/21 - 1 polyp removed

boxhill
Posts: 756
Joined: Fri Apr 06, 2018 11:40 am

Re: Stage 3, likelihood of recurrence after resection & chemotherapy

Postby boxhill » Mon Nov 08, 2021 1:29 pm

That's an easy question to answer: nothing automatically means anything. :lol:

Seriously, there are many things that can cause CEA to rise. If CEA is a good marker for her, a certain level of concern may be warranted, but it is my understanding that a trend is more significant than a single reading. I know it is hard not to worry, but try not to freak out unless or until you know there is definitely something there. And if there is, gather yourself and help her deal with it. Best to you.
F, 64 at DX CRC Stage IV
3/17/18 blockage, r hemi
11 of 25 LN,5 mesentery nodes
5mm liver met
pT3 pN2b pM1
BRAF wild, KRAS G12D
dMMR, MSI-H
5/18 FOLFOX
7/18 and 11/18 CT NED
12/18 MRI 5mm liver mass, 2 LNs in porta hepatis
12/31/18 Keytruda
6/19 Multiphasic CT LNs normal, Liver stable
6/28/19 Pause Key, predisone for joint pain
7/31/19 Restart Key
9/19 CT stable
Pain: all fails but Celebrex
12/23/19 CT stable
5/19 MRI stable/NED
6/20 Stop Key
All MRIs NED

Julia123
Posts: 8
Joined: Sun Nov 07, 2021 4:00 pm

Re: Stage 3, likelihood of recurrence after resection & chemotherapy

Postby Julia123 » Mon Nov 08, 2021 2:11 pm

ANDRETEXAS wrote:I was Stage IIIb ...see below. Stay positive..and have your husband get as much exercise and rest he can during chemo. Come back to this forum for any questions you have. There are many people here who can give you guidance and advice.



hI, I'm new here. (Ukraine) I do not know English well tell me what type of tumor did you have?



_____________________________________
04.06(jun)2021
Mucinous adenocarcinoma sigmoid cancer
( ICD-O-3: 8480/3)

pT3 pN1a(1/36) M0 TD1 L0 V0 Pn0
CEA 2, CA19-9 0.69

MMEp/MSS: MLH1+, PMS2+,MSH2+, MSH6+



09.06 extended resection (with abdominal wall)

28.07 Folfox6 - 12 cycles

24.09 magnetic resonance tomography- clear
Cea 2.2
8.11.2021 - 7 cycles n
04.06 (июнь) 2021 г.
Муцинозная аденокарцинома сигмовидного рака
(ICD-O-3: 8480/3)

pT3 pN1a (1/36) M0 TD1 L0 V0 Pn0
CEA 2, CA19-9 0,69

MMEp / MSS: MLH1 +, PMS2 +, MSH2 +, MSH6 +



09.06 расширенная резекция (с брюшной стенкой)

28.07 Folfox6 - 12 циклов

24.09 Магнитно-резонансная томография - очистить
Cea 2.2
1.12.2021 - 8 cycles done now

Julia123
Posts: 8
Joined: Sun Nov 07, 2021 4:00 pm

Re: Stage 3, likelihood of recurrence after resection & chemotherapy

Postby Julia123 » Tue Nov 09, 2021 4:26 am

vancanes319 wrote:Hi, I could not login under my old user name because I do not have access to my old email address.

I was diagnosed in November 2004 at 41 years old with Stage IIIC with 6 nodes positive and a colostomy. I had 12 rounds of Folfox with Oxi. My colostomy was reversed after my chemo was completed.

My four year old son was my driving force. I was told by MSKCC to walk a lot (the first two or three years I walked around 4 miles a day 5/6 times a week, eat a healthy diet, limit red meat and no processed food, take a baby aspirin a day. I'm not sure if the baby aspirin is still advised but I continue to take it.

There is hope always.........

Lots of love and thoughts.

Lori




why was + Oxi prescribed? what type of tumor was it? how aggressive is g? I have 3b mucinous, surgery - sigmoid resection, one lymph node out of 36 is damaged, folfox is 12 rounds. 7 is done now. I'm afraid that I'm missing something in the treatment (((((
04.06 (июнь) 2021 г.
Муцинозная аденокарцинома сигмовидного рака
(ICD-O-3: 8480/3)

pT3 pN1a (1/36) M0 TD1 L0 V0 Pn0
CEA 2, CA19-9 0,69

MMEp / MSS: MLH1 +, PMS2 +, MSH2 +, MSH6 +



09.06 расширенная резекция (с брюшной стенкой)

28.07 Folfox6 - 12 циклов

24.09 Магнитно-резонансная томография - очистить
Cea 2.2
1.12.2021 - 8 cycles done now

roadrunner
Posts: 179
Joined: Sun Jan 12, 2020 8:46 pm

Re: Stage 3, likelihood of recurrence after resection & chemotherapy

Postby roadrunner » Tue Nov 09, 2021 12:09 pm

Just pointing out that there may be some confusion here. FOLFOX by definition includes Oxaliplatin, that’s the “OX” bit. If you’ve had 7 of FOLFOX, you’ve had a lot of Oxaliplatin.
7/19: Rectal cancer: Initially staged as IIIA, T2N1M0
Initially approx 4.25 cm, low/mid rectum, mod. well diff. adenocarcinoma
8/22 -10/14 4 rounds FOLFOX neoadjuvant, 3 w/Oxiplatin (lots of side effects/reduced size est. 70-75%)
neoadjuvant chemorad 11/19
4 rounds of FOLFOX July-August 2020
ncCR found 10/20; multiple biopsies negative
TAE 11/20, small amount of tumor removed, lung nodules orig id’d 6/20 stable Nov 2020
Chest CT 3/30/21 small growth in 2 nodules (3 and 5mm)
Stable in 6/28 scan.

Julia123
Posts: 8
Joined: Sun Nov 07, 2021 4:00 pm

Re: Stage 3, likelihood of recurrence after resection & chemotherapy

Postby Julia123 » Sat Nov 13, 2021 1:55 pm

Koreysue wrote:I was 39 at diagnosis- stage 3 in 2017
Had surgery and chemo (folfox)
no recurrence so far

Yes, i can offer some pointers if ihis cheno is folfox. I will wait for an update from you,
I too recommend staying active even in treatment when possible. My onc said that can be huge in cancer prevention. With Folfox there is cold sensitivity, so walking outside probably wont be possible depending on your climate, but a stationary bike could work.

And yes- I say go with a chest port for chemo access

ksue


hello, what type of tumor did you have, G 1-2-3?
04.06 (июнь) 2021 г.
Муцинозная аденокарцинома сигмовидного рака
(ICD-O-3: 8480/3)

pT3 pN1a (1/36) M0 TD1 L0 V0 Pn0
CEA 2, CA19-9 0,69

MMEp / MSS: MLH1 +, PMS2 +, MSH2 +, MSH6 +



09.06 расширенная резекция (с брюшной стенкой)

28.07 Folfox6 - 12 циклов

24.09 Магнитно-резонансная томография - очистить
Cea 2.2
1.12.2021 - 8 cycles done now


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