What is the side effect of folfiri and zaltrap

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Alex83
Posts: 15
Joined: Sun May 31, 2020 4:39 pm

What is the side effect of folfiri and zaltrap

Postby Alex83 » Wed Jun 03, 2020 3:19 pm

Mom started today the first cycle of folfiri and zaltrap, she has to take at the hospital and stay for 48 hrs, everything is going well so far but the oncologist said she might lose the hair or become thin.
However any one tried this protocol and as per expert zaltrap is a new medicine approved by FDA in 2012 and works with folfiri pretty well and could give better result than using avastin according to statistics.
Please share with me your experience with this 2nd line chemo therapy.
Thanks.
Supporting my mom
November 2017, Colon re-suction adenocarcinoma Moderately differentiated (3 lymph nodes active)
October 2018, CT scan showed nodules in lung and liver
Starts chemo (Oxalaplatin and Avastin) + Xeloda
January 2020 all nodules gone.
May 2020, again nodules in Lung
June 2020, starts new protocol (Folfiri and Zaltrap)
Kras mutated g12c
MSI negative

stu
Posts: 1613
Joined: Sat Aug 17, 2013 5:46 pm

Re: What is the side effect of folfiri and zaltrap

Postby stu » Thu Jun 04, 2020 5:32 am

Hi ,
I can’t help with the advise but wanted to wish your mum all the very best and will look with interest to see how she gets on .
Take care ,
Stu
supporter to my mum who lives a great life despite a difficult diagnosis
stage4 2009 significant spread to liver
2010 colon /liver resection
chemo following recurrence
73% of liver removed
enjoying life treatment free
2016 lung resection
Oct 2017 nice clear scan . Two lung nodules disappeared
Oct 2018. Another clear scan .

Alex83
Posts: 15
Joined: Sun May 31, 2020 4:39 pm

Re: What is the side effect of folfiri and zaltrap

Postby Alex83 » Thu Jun 04, 2020 2:01 pm

stu wrote:Hi ,
I can’t help with the advise but wanted to wish your mum all the very best and will look with interest to see how she gets on .
Take care ,
Stu


Thank you stu, so far there is no major side effect except raising in blood sugar.
Hope to cross this period successfully.
Supporting my mom
November 2017, Colon re-suction adenocarcinoma Moderately differentiated (3 lymph nodes active)
October 2018, CT scan showed nodules in lung and liver
Starts chemo (Oxalaplatin and Avastin) + Xeloda
January 2020 all nodules gone.
May 2020, again nodules in Lung
June 2020, starts new protocol (Folfiri and Zaltrap)
Kras mutated g12c
MSI negative

User avatar
beach sunrise
Posts: 1034
Joined: Thu Mar 05, 2020 7:14 pm

Re: What is the side effect of folfiri and zaltrap

Postby beach sunrise » Thu Jun 04, 2020 3:03 pm

Hi Alex, I hope it works for your Mum. Can I ask why her glucose is rising? Has she had trouble with it before treatment?
8/19 RC CEA 82.6 T3N0M0
5FU/rad 6 wk
IVC 75g 1 1/2 wks before surgery. Continue 2x a week
Surg 1/20 -margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24 post 5.9
FOLFOX
7 rds 6-10 CEA 11.4 No more
CEA
7/20 11.1 8.8
8/20 7.8
9/20 8.8, 9, 8.6
10/20 8.1
11/20 8s
12/20 8s-9s
ADAPT++++ chrono
CEA
10/23/22 26.x
12/23/22 22.x
2023
1/5 17.1
1/20 15.9
3/30 14.9
6/12 13.3
8/1 2.1
Nodule RML SUV 1.3 5mm
Rolles 3 of 4 lung nodules cancer
KRAS
Chem-sens test failed Not enough ca cells to test

Alex83
Posts: 15
Joined: Sun May 31, 2020 4:39 pm

Re: What is the side effect of folfiri and zaltrap

Postby Alex83 » Thu Jun 04, 2020 3:21 pm

beach sunrise wrote:Hi Alex, I hope it works for your Mum. Can I ask why her glucose is rising? Has she had trouble with it before treatment?


She does not have diabetes, but the doctor said that the high blood sugar due to the treatment (folfori and zaltrap) side effect
Supporting my mom
November 2017, Colon re-suction adenocarcinoma Moderately differentiated (3 lymph nodes active)
October 2018, CT scan showed nodules in lung and liver
Starts chemo (Oxalaplatin and Avastin) + Xeloda
January 2020 all nodules gone.
May 2020, again nodules in Lung
June 2020, starts new protocol (Folfiri and Zaltrap)
Kras mutated g12c
MSI negative

User avatar
beach sunrise
Posts: 1034
Joined: Thu Mar 05, 2020 7:14 pm

Re: What is the side effect of folfiri and zaltrap

Postby beach sunrise » Thu Jun 04, 2020 3:38 pm

Thank you for the reply. Its good its chemo related then. I never had problems either until chemo. When I asked during neo-adjuvant the onc told me the same thing and I was just on 5FU pump. Mine is till high with adjuvant FOLFOX6. I've been experimenting with fasting before blood draws and it goes up and down but still high.
8/19 RC CEA 82.6 T3N0M0
5FU/rad 6 wk
IVC 75g 1 1/2 wks before surgery. Continue 2x a week
Surg 1/20 -margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24 post 5.9
FOLFOX
7 rds 6-10 CEA 11.4 No more
CEA
7/20 11.1 8.8
8/20 7.8
9/20 8.8, 9, 8.6
10/20 8.1
11/20 8s
12/20 8s-9s
ADAPT++++ chrono
CEA
10/23/22 26.x
12/23/22 22.x
2023
1/5 17.1
1/20 15.9
3/30 14.9
6/12 13.3
8/1 2.1
Nodule RML SUV 1.3 5mm
Rolles 3 of 4 lung nodules cancer
KRAS
Chem-sens test failed Not enough ca cells to test

Alex83
Posts: 15
Joined: Sun May 31, 2020 4:39 pm

Re: What is the side effect of folfiri and zaltrap

Postby Alex83 » Thu Jun 04, 2020 5:22 pm

beach sunrise wrote:Thank you for the reply. Its good its chemo related then. I never had problems either until chemo. When I asked during neo-adjuvant the onc told me the same thing and I was just on 5FU pump. Mine is till high with adjuvant FOLFOX6. I've been experimenting with fasting before blood draws and it goes up and down but still high.


Wish to get an excellent result you are taking Folfox only in your treatment
Supporting my mom
November 2017, Colon re-suction adenocarcinoma Moderately differentiated (3 lymph nodes active)
October 2018, CT scan showed nodules in lung and liver
Starts chemo (Oxalaplatin and Avastin) + Xeloda
January 2020 all nodules gone.
May 2020, again nodules in Lung
June 2020, starts new protocol (Folfiri and Zaltrap)
Kras mutated g12c
MSI negative

User avatar
beach sunrise
Posts: 1034
Joined: Thu Mar 05, 2020 7:14 pm

Re: What is the side effect of folfiri and zaltrap

Postby beach sunrise » Thu Jun 04, 2020 5:31 pm

Yes, just folfox.
8/19 RC CEA 82.6 T3N0M0
5FU/rad 6 wk
IVC 75g 1 1/2 wks before surgery. Continue 2x a week
Surg 1/20 -margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24 post 5.9
FOLFOX
7 rds 6-10 CEA 11.4 No more
CEA
7/20 11.1 8.8
8/20 7.8
9/20 8.8, 9, 8.6
10/20 8.1
11/20 8s
12/20 8s-9s
ADAPT++++ chrono
CEA
10/23/22 26.x
12/23/22 22.x
2023
1/5 17.1
1/20 15.9
3/30 14.9
6/12 13.3
8/1 2.1
Nodule RML SUV 1.3 5mm
Rolles 3 of 4 lung nodules cancer
KRAS
Chem-sens test failed Not enough ca cells to test

boxhill
Posts: 789
Joined: Fri Apr 06, 2018 11:40 am

Re: What is the side effect of folfiri and zaltrap

Postby boxhill » Sat Jun 06, 2020 1:21 pm

The steroid often given with infusions to head off reactions often raises blood sugar, too.
F, 64 at DX CRC Stage IV
3/17/18 blockage, r hemi
11 of 25 LN,5 mesentery nodes
5mm liver met
pT3 pN2b pM1
BRAF wild, KRAS G12D
dMMR, MSI-H
5/18 FOLFOX
7/18 and 11/18 CT NED
12/18 MRI 5mm liver mass, 2 LNs in porta hepatis
12/31/18 Keytruda
6/19 Multiphasic CT LNs normal, Liver stable
6/28/19 Pause Key, predisone for joint pain
7/31/19 Restart Key
9/19 CT stable
Pain: all fails but Celebrex
12/23/19 CT stable
5/20 MRI stable/NED
6/20 Stop Key
All MRIs NED

Alex83
Posts: 15
Joined: Sun May 31, 2020 4:39 pm

Re: What is the side effect of folfiri and zaltrap

Postby Alex83 » Mon Jun 08, 2020 11:17 am

boxhill wrote:The steroid often given with infusions to head off reactions often raises blood sugar, too.


Yes the blood sugar raising up for 2 days up to 360, also she feels so tired is that kind of these side effects
Supporting my mom
November 2017, Colon re-suction adenocarcinoma Moderately differentiated (3 lymph nodes active)
October 2018, CT scan showed nodules in lung and liver
Starts chemo (Oxalaplatin and Avastin) + Xeloda
January 2020 all nodules gone.
May 2020, again nodules in Lung
June 2020, starts new protocol (Folfiri and Zaltrap)
Kras mutated g12c
MSI negative

michelle c
Posts: 1929
Joined: Wed Dec 02, 2009 3:58 am

Re: What is the side effect of folfiri and zaltrap

Postby michelle c » Tue Jun 09, 2020 5:52 am

I only had FOLFIRI but it played havoc with my digestive system, my hair thinned and it affected my neutrophils and had to have neupogen injections a few times between treatments to help boost them. Best wishes to your mom.
May 25 2009 Dx with CC (sigmoid colon) 2 days after my 44th b'day
CEA prior to surgery 4.7
Jun 3 2009 LAR - Stage III 3/10 lymph nodes
Jul 6 - Dec 10 2009 - 12 cycles FOLFIRI
Genetic testing - inconclusive for Lynch
Jul 2012 port removed & hernia repair

Cured
Posts: 581
Joined: Thu Nov 27, 2008 10:53 pm
Location: MO

Re: What is the side effect of folfiri and zaltrap

Postby Cured » Tue Jun 09, 2020 2:23 pm

Alex, Best wishes to your Mom. Adding in a prayer.
I have never even heard of Zaltrap until you’re post; so please keep us posted on how she does.
I am currently doing Folfiri but with Avastin added. However I refused treatment this week as it weakened my immune system too much. Plus mouth sores were hurting and causing the glands in my neck to swell.

Michelle C.: I’m with you in that Folfiri can be messy.
Alex: buy adult diapers by the case as the diarrhea can be explosive. Now they infuse me with Atropine at the start, to avoid immediate diarrhea; which seems to work, but the night of the infusion is uncomfortable. One doesn’t know how much is due to the chemo or to the helper drugs.

I’m planning to take a non “standard of care” treatment this week, using Fenbendazole (dog wormer) plus supplements. As my neutrophils are low and a 2008 study showed neutrophils to increase with use of FZ. We met a man who is successfully taking the regimen. Online there are tales of people with amazing responses to it.I came to the Club today to see if anyone has problems who took this. The myth is at my cancer story.rocks.

I believe that each of us needs to be in touch with his or her body. In all of my previous rounds of chemo I never needed blood products or pharmaceuticals to increase White Blood Counts. I’m older now (plus the Onc said my body is different due to previous Chemo) so I’m making sure I don’t get too weak.

May God help your Mom and you.
7-18 Stg 4
5-08:Stg 3 Rectal: 6/14 Nodes
Ace Surgn Remvd 90%Rectm,lots of Colon-Full Incision
Ileo Rev'd 6 Mos.
Radian+5fu Pre-Surg
FOLFOX 8 Cyc,1-09
Clear Scope 8-17; CEA 2-18
Glory to God! Healed by prayers of many: for 10 yrs
7-18: tumor pressing brain Remove
Met to lung. CEA 6.9
Folfiri
CEA 4.5 after 1 chemo
8rds CEA 3 1.8, 2.3,1.7 then up:32
12rd Folfiri
Avastin ev 2 wks
Seizure Anti-seiz meds work-no driving for 6m
4-20PET: Lng spots=Chemo
2-21 tumr gth =Folfiri
Radiation 7-22

Alex83
Posts: 15
Joined: Sun May 31, 2020 4:39 pm

Re: What is the side effect of folfiri and zaltrap

Postby Alex83 » Thu Jun 11, 2020 11:34 am

Cured wrote:Alex, Best wishes to your Mom. Adding in a prayer.
I have never even heard of Zaltrap until you’re post; so please keep us posted on how she does.
I am currently doing Folfiri but with Avastin added. However I refused treatment this week as it weakened my immune system too much. Plus mouth sores were hurting and causing the glands in my neck to swell.

Michelle C.: I’m with you in that Folfiri can be messy.
Alex: buy adult diapers by the case as the diarrhea can be explosive. Now they infuse me with Atropine at the start, to avoid immediate diarrhea; which seems to work, but the night of the infusion is uncomfortable. One doesn’t know how much is due to the chemo or to the helper drugs.

I’m planning to take a non “standard of care” treatment this week, using Fenbendazole (dog wormer) plus supplements. As my neutrophils are low and a 2008 study showed neutrophils to increase with use of FZ. We met a man who is successfully taking the regimen. Online there are tales of people with amazing responses to it.I came to the Club today to see if anyone has problems who took this. The myth is at my cancer story.rocks.

I believe that each of us needs to be in touch with his or her body. In all of my previous rounds of chemo I never needed blood products or pharmaceuticals to increase White Blood Counts. I’m older now (plus the Onc said my body is different due to previous Chemo) so I’m making sure I don’t get too weak.

May God help your Mom and you.

Mom side effect of zaltrap and folfiri for the 1st session are
Diaherra and weakness so far
Supporting my mom
November 2017, Colon re-suction adenocarcinoma Moderately differentiated (3 lymph nodes active)
October 2018, CT scan showed nodules in lung and liver
Starts chemo (Oxalaplatin and Avastin) + Xeloda
January 2020 all nodules gone.
May 2020, again nodules in Lung
June 2020, starts new protocol (Folfiri and Zaltrap)
Kras mutated g12c
MSI negative

Alex83
Posts: 15
Joined: Sun May 31, 2020 4:39 pm

Re: What is the side effect of folfiri and zaltrap

Postby Alex83 » Sun Aug 02, 2020 3:01 pm

Hi friends,
after 4 sessions of folfiri and zaltrap, mom had a CT scan and the result was excellent (absence of nodules and decrease of other from 25mm to 7mm).
But I would like to know about the adenopathy in mediastinal since it exists 2 adenopathy, so what are these adenopathy mediastinal means?

Thanks
Supporting my mom
November 2017, Colon re-suction adenocarcinoma Moderately differentiated (3 lymph nodes active)
October 2018, CT scan showed nodules in lung and liver
Starts chemo (Oxalaplatin and Avastin) + Xeloda
January 2020 all nodules gone.
May 2020, again nodules in Lung
June 2020, starts new protocol (Folfiri and Zaltrap)
Kras mutated g12c
MSI negative


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