How accurate is foundation 1 / MSI-H testing?

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Joined: Sun Mar 03, 2019 5:27 am

How accurate is foundation 1 / MSI-H testing?

Postby Wewillfight » Thu Dec 26, 2019 11:31 am

Are there stats on the accuracy of these tests?

How important is the quality if tissue sample?

Could incorrect sampling occur ?

It got me thinking there must be some error and therefore some value in late stagd immunotherapy in MSS patients?
Feb 2017 (35yr) stage IIIc, surgery, colostomy, 2 nodes ( crohns colitis since 17yr
6 months FOLFOX
MSS - low mutation burden, TMB=1
Rejoin June 2018
December 2018 symptoms
March 2019: recurrence , surgery , some spread to pertineum
Jan-June 2019 Folfiri+Cetux
No spread.
August 2019: partial blockage symptoms
Nov 2019: Aborted small bowel resection, venting gastronomy fitted , home TPN
Dec 2019- Jan 2020: Keytruda
Feb 2020: reaction
Feb 2020: treatment ceased, TPN withdrawn
March 18 2020: RIP Brother.

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