I'm happy to report that after multiple attempts with multiple standards treatments, I have a found a trial that is promising for folks with the BRAF mutation. It does seem that some of us respond to agents such as folfox of folfiri, but I don't seem to one of them. The triplet therapy associated with the Beacon trial worked like a charm on me for three months, then became emphatically resistant. this new protocol aims to address the pathways that cause resistance. If anyone is interested, I can try to explain. At this point, however, I just hopeful I get into the trial soon -- first on the waiting list for the cohort starting immediately. If that doesn't work, I should be in the second cohort in 2 months.
I would be interested in hearing from folks with this mutation. What has worked for you?
Best