Hi my dad got back his genome test.
What's this mean.
PD-L1 - High
RNA expression score 28
Thanks,
Nate
Pd-L1 high
Pd-L1 high
Caregiver to 80M
DX:CC,RC,desc
11/2018 rightPain
1/19/19 scopy,path
1/23 CTscan
2/19 surgery
2/26-2/28 NGTube
2/28-3/14 TPN bc ileus
3/2 2nd surgeryCloseOpenWound
3/4-3/28 woundVac
size: 6cm Adenocarcinoma
grade Poorly
Stage IIIC T3N2aMx
PositiveLymph:5of28
BaselineCEA:68
LVI:Y
PNI:N
Surgical margins:clear
MSI:MMR (MLH1, MSH2, MSH6, PMS2) Intact nuclear expression
Lynch status:N
Laparascopic, partial colectomy
CEA:3/28/19 2.8
Chemo:4/16/19-9/17/19 5FU,12cycles,every 14days,leucoverin,zofran,Dexamethasone
DX:CC,RC,desc
11/2018 rightPain
1/19/19 scopy,path
1/23 CTscan
2/19 surgery
2/26-2/28 NGTube
2/28-3/14 TPN bc ileus
3/2 2nd surgeryCloseOpenWound
3/4-3/28 woundVac
size: 6cm Adenocarcinoma
grade Poorly
Stage IIIC T3N2aMx
PositiveLymph:5of28
BaselineCEA:68
LVI:Y
PNI:N
Surgical margins:clear
MSI:MMR (MLH1, MSH2, MSH6, PMS2) Intact nuclear expression
Lynch status:N
Laparascopic, partial colectomy
CEA:3/28/19 2.8
Chemo:4/16/19-9/17/19 5FU,12cycles,every 14days,leucoverin,zofran,Dexamethasone
Re: Pd-L1 high
This means your dad might actually be a good candidate for a PD-L1 inhibitor. This is usually a bad sign as PD-L1 inhibits the immune system from attacking the cancer. Inhibition of this in people with high expression in combination with chemotherapy seems to have much better results. At least in lung cancer and with PD-1. No reason to assume the same can't happen with colon cancer. The following may be of interest to you.
This is about the typical clinical outcomes of patients with PD-L1 high expression.
https://www.ncbi.nlm.nih.gov/pubmed/30873025
This is about PD-1 and PDL1 inhibitors in general. Note Keytruda and Opdivo are PD-1 inhibitors lesser known are the PD-L1 inhibitors Tecentriq, and Bavencio. I believe the later Pfizer is conducting many clinical trials with in combinations with other chemotherapy
https://en.wikipedia.org/wiki/PD-1_and_PD-L1_inhibitors
And this last has to do with possible therapies:
https://www.ncbi.nlm.nih.gov/pubmed/31488176
Good Luck
GrouseMan
This is about the typical clinical outcomes of patients with PD-L1 high expression.
https://www.ncbi.nlm.nih.gov/pubmed/30873025
This is about PD-1 and PDL1 inhibitors in general. Note Keytruda and Opdivo are PD-1 inhibitors lesser known are the PD-L1 inhibitors Tecentriq, and Bavencio. I believe the later Pfizer is conducting many clinical trials with in combinations with other chemotherapy
https://en.wikipedia.org/wiki/PD-1_and_PD-L1_inhibitors
And this last has to do with possible therapies:
https://www.ncbi.nlm.nih.gov/pubmed/31488176
Good Luck
GrouseMan
DW 53 dx Jun 2013
CT mets Liver Spleen lung. IVb CEA~110
Jul 2013 Sig Resct
8/13 FolFox,Avastin 12Tx mild sfx, Ongoing 5-FU Avastin every 3 wks.
CEA: good marker
7/7/14 CT Can't see the spleen Mets.
8/16/15 CEA Up, CT new abdominal mets. Iri, 5-FU, Avastin every 2 wks.
1/16 Iri, Erbitux and likely Avastin (Trial) CEA going >.
1/17 CEA up again dropped from Trial, Mets growth 4-6 mm in abdomen
5/2/17 Failed second trial, Hospitalized 15 days 5/11. Home Hospice 5/26, at peace 6/4/2017
CT mets Liver Spleen lung. IVb CEA~110
Jul 2013 Sig Resct
8/13 FolFox,Avastin 12Tx mild sfx, Ongoing 5-FU Avastin every 3 wks.
CEA: good marker
7/7/14 CT Can't see the spleen Mets.
8/16/15 CEA Up, CT new abdominal mets. Iri, 5-FU, Avastin every 2 wks.
1/16 Iri, Erbitux and likely Avastin (Trial) CEA going >.
1/17 CEA up again dropped from Trial, Mets growth 4-6 mm in abdomen
5/2/17 Failed second trial, Hospitalized 15 days 5/11. Home Hospice 5/26, at peace 6/4/2017
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