Right vs Left colon

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natelaugh
Posts: 95
Joined: Wed Apr 03, 2019 11:40 pm

Right vs Left colon

Postby natelaugh » Sun Apr 07, 2019 10:18 pm

Hi,

I read that right colon cancer is harder to cure than left colon cancer. Any experience/thought on this?

Thanks,
Nate.
Caregiver to 80M
DX:CC,RC,desc
11/2018 rightPain
1/19/19 scopy,path
1/23 CTscan
2/19 surgery
2/26-2/28 NGTube
2/28-3/14 TPN bc ileus
3/2 2nd surgeryCloseOpenWound
3/4-3/28 woundVac
size: 6cm Adenocarcinoma
grade Poorly
Stage IIIC T3N2aMx
PositiveLymph:5of28
BaselineCEA:68
LVI:Y
PNI:N
Surgical margins:clear
MSI:MMR (MLH1, MSH2, MSH6, PMS2) Intact nuclear expression
Lynch status:N
Laparascopic, partial colectomy
CEA:3/28/19 2.8
Chemo:4/16/19-9/17/19 5FU,12cycles,every 14days,leucoverin,zofran,Dexamethasone

rp1954
Posts: 1540
Joined: Mon Jun 13, 2011 1:13 am

Re: Right vs Left colon

Postby rp1954 » Mon Apr 08, 2019 12:29 am

Most people are not right sided CRC. One way to use this site is to trawl through the histories.

Previous stories can be scary but they are a way to identify problems and hurdles earlier, without smacking into them personally. Addressing problems early can remove or ameliorate those often left for later as a surprise. If you indexed and outlined your right sided finds here it might help generate discussion with other RHS patients and old timers.
watchful, active researcher and caregiver for stage IVb/c CC. surgeries 4/10 sigmoid etc & 5/11 para-aortic LN cluster; 8 yrs immuno-Chemo for mCRC; now no chemo
most of 2010 Life Extension recommendations and possibilities + more, some (much) higher, peaking ~2011-12, taper to almost nothing mid 2018, mostly IV C

KimT
Posts: 693
Joined: Sat Feb 20, 2010 8:53 pm

Re: Right vs Left colon

Postby KimT » Mon Apr 08, 2019 4:05 am

I’m 10 years out from a stage 2 right sided colon cancer that I did not do chemo for. 10 years ago, I heard right sided cancer was a better diagnosis. Data changes. IMO every case is different.
2/10 dx colon cancer
right hemicolectomy 3/19/10
Stage 2a 0/43 nodes
Lynch syndrome
3/14/10 colon resection/ removal of metal clips
Nov 11 dx ovarian cancer

mpbser
Posts: 953
Joined: Wed Apr 19, 2017 11:52 am

Re: Right vs Left colon

Postby mpbser » Mon Apr 08, 2019 5:35 am

Latest research shows no significant differences in the treatment responses for right-sided tumors compared with left-sided tumors, including or excluding the rectum. However, patients suffering from left-sided CC were revealed to exhibit better clinical outcomes compared with patients suffering from right-sided CC when molecularly-targeted agent regimens were administered.

https://www.ncbi.nlm.nih.gov/pubmed/30675246
Wife 4/17 Dx age 45
5/17 LAR
Adenocarcinoma
low grade
1st primary T3 N2b M1a
Stage IVA
8/17 Sub-total colectomy
2nd primary 5.5 cm T1 N0
9 of 96 nodes
CEA: < 2.9
MSS
Lynch no; KRAS wild
Immunohistochemsistry Normal
Fall 2017 FOLFOX shrank the 1 met in liver
1/18 Liver left hepatectomy seg 4
5/18 CT clear
12/18 MRI 1 liver met
3/7/19 Resection & HAI
4/1/19 Folfiri & FUDR
5/13/19 HAI pump catheter dislodge, nearly bled to death
6-7 '19 5FU 4 cycles
NED

Beckster
Posts: 433
Joined: Thu Jan 12, 2017 3:01 pm
Location: New Jersey

Re: Right vs Left colon

Postby Beckster » Mon Apr 08, 2019 7:20 am

Welcome....I am right sided too....When I met with my onc, we discussed the bilogical difference between right and left (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768473/). In stages I-III, chemo is the same for both sides; however, if a right sided I-III. has a recurrence (now stage IV), it limits chemo agents because some do not work on right sided and I would be limited on what they can use. My oncologist told me that if I had a recurrence, they would be less options for chemo agents. Pathology needs to be done at a major cancer center....many Stage II have had a different pathology outcome when they sought out a second opinion...viewtopic.php?f=1&t=60639&start=15

You need to advocate for yourself and make sure that you get ALL the information needed to make a decision. Current research is suggesting that Stage II right sided has a better prognosis than left sided. Stage III does not.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089587/

https://www.practiceupdate.com/content/ ... mors/63276

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662378/

https://www.researchgate.net/publicatio ... tic_review

Beckster



natelaugh wrote:Hi,

I read that right colon cancer is harder to cure than left colon cancer. Any experience/thought on this?

Thanks,
Nate.
57/F
DX:(CC) 10/19/16
11/4/16- Lap right hemi(cecum)
CEA- Pre Op (1.9), Pre Chemo (2.5)
Type: Adenocarcinoma
Tumor size:3.5 cm x 2.5 x 0.7 cm
Grade: G3 (path) G2 (pre-op)
TNM: T3N0M0/IIA
LN: 0/24
LVI present
Surgical margins: clear
MSS
12/27/2016 - Capeox, anaphylactic reaction
1/2/17 to 6/9/17- Xeloda
6/17,12/17,6/18,12/18,6/19,12/19,12/20 CT Scan NED :D
CEA- 6/17- 3.6, 9/17- 2.8 12/17-2.8, 3/18-3.1, 6/18-3.0, 9/18 2.8, 12/18 2.5 3/19 3.1 6/19 3.1 9/19 2.6 12/19 2.8 6/20 3.0 12/20 2.7
Clear Colonoscopy 10/17, 11/19 :D

User avatar
O Stoma Mia
Posts: 1603
Joined: Sat Jun 22, 2013 6:29 am

Re: Right vs Left colon

Postby O Stoma Mia » Mon Apr 08, 2019 9:07 am

Beckster wrote:Welcome....I am right sided too....When I met with my onc, we discussed the bilogical difference between right and left (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768473/). In stages I-III, chemo is the same for both sides; however, if a right sided I-III. has a recurrence (now stage IV), it limits chemo agents because some do not work on right sided and I would be limited on what they can use. My oncologist told me that if I had a recurrence, they would be less options for chemo agents. Pathology needs to be done at a major cancer center....many Stage II have had a different pathology outcome when they sought out a second opinion...viewtopic.php?f=1&t=60639&start=15

You need to advocate for yourself and make sure that you get ALL the information needed to make a decision. Current research is suggesting that Stage II right sided has a better prognosis than left sided. Stage III does not.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089587/

https://www.practiceupdate.com/content/ ... mors/63276

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662378/

https://www.researchgate.net/publicatio ... tic_review

Beckster


Beckster -

Thank you for providing supporting evidence on the right colon vs. left colon issue. However, three of the links that you provided are invalid and need to be corrected.

A correct representation of a URL on this message board generally requires that the URL be enclosed by the bracketed [ URL ] and [ /URL ] tags. If they aren't enclosed by the bracketed URL tags, then the longer URLs are truncated to 50 character limit and the missing parts of the URL are replaced by three dots: . . . But this causes the URL to become invalid and unreadable.

- - -
FYI, Here are three valid URLs that you can use to replace the three invalid ones in your original post:

https://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=60639#p482969

https://www.practiceupdate.com/content/asco-gi-2018-unselected-patients-with-right-sided-metastatic-colorectal-tumors-experience-worse-disease-free-survival-than-those-with-left-sided-tumors/63276

https://www.researchgate.net/publication/268221060_Is_right-sided_colon_cancer_different_to_left-sided_colorectal_cancer_-_A_systematic_review

Beckster
Posts: 433
Joined: Thu Jan 12, 2017 3:01 pm
Location: New Jersey

Re: Right vs Left colon

Postby Beckster » Mon Apr 08, 2019 9:13 am

Beckster wrote:Welcome....I am right sided too....When I met with my onc, we discussed the bilogical difference between right and left (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768473/). In stages I-III, chemo is the same for both sides; however, if a right sided I-III. has a recurrence (now stage IV), it limits chemo agents because some do not work on right sided and I would be limited on what they can use. My oncologist told me that if I had a recurrence, they would be less options for chemo agents. Pathology needs to be done at a major cancer center....many Stage II have had a different pathology outcome when they sought out a second opinion...viewtopic.php?f=1&t=60639&start=15

You need to advocate for yourself and make sure that you get ALL the information needed to make a decision. Current research is suggesting that Stage II right sided has a better prognosis than left sided. Stage III does not.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089587/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662378/
https://coloncancersupport.colonclub.co ... 39#p482969
https://www.practiceupdate.com/content/ ... mors/63276
https://www.researchgate.net/publicatio ... tic_review
Top



Beckster



natelaugh wrote:Hi,

I read that right colon cancer is harder to cure than left colon cancer. Any experience/thought on this?

Thanks,
Nate.
57/F
DX:(CC) 10/19/16
11/4/16- Lap right hemi(cecum)
CEA- Pre Op (1.9), Pre Chemo (2.5)
Type: Adenocarcinoma
Tumor size:3.5 cm x 2.5 x 0.7 cm
Grade: G3 (path) G2 (pre-op)
TNM: T3N0M0/IIA
LN: 0/24
LVI present
Surgical margins: clear
MSS
12/27/2016 - Capeox, anaphylactic reaction
1/2/17 to 6/9/17- Xeloda
6/17,12/17,6/18,12/18,6/19,12/19,12/20 CT Scan NED :D
CEA- 6/17- 3.6, 9/17- 2.8 12/17-2.8, 3/18-3.1, 6/18-3.0, 9/18 2.8, 12/18 2.5 3/19 3.1 6/19 3.1 9/19 2.6 12/19 2.8 6/20 3.0 12/20 2.7
Clear Colonoscopy 10/17, 11/19 :D

Beckster
Posts: 433
Joined: Thu Jan 12, 2017 3:01 pm
Location: New Jersey

Re: Right vs Left colon

Postby Beckster » Mon Apr 08, 2019 9:16 am

O Stoma Mia wrote:
Beckster wrote:Welcome....I am right sided too....When I met with my onc, we discussed the bilogical difference between right and left (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768473/). In stages I-III, chemo is the same for both sides; however, if a right sided I-III. has a recurrence (now stage IV), it limits chemo agents because some do not work on right sided and I would be limited on what they can use. My oncologist told me that if I had a recurrence, they would be less options for chemo agents. Pathology needs to be done at a major cancer center....many Stage II have had a different pathology outcome when they sought out a second opinion...viewtopic.php?f=1&t=60639&start=15

You need to advocate for yourself and make sure that you get ALL the information needed to make a decision. Current research is suggesting that Stage II right sided has a better prognosis than left sided. Stage III does not.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089587/

https://www.practiceupdate.com/content/ ... mors/63276

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662378/

https://www.researchgate.net/publicatio ... tic_review

Beckster


Beckster -

Thank you for providing supporting evidence on the right colon vs. left colon issue. However, three of the links that you provided are invalid and need to be corrected.

A correct representation of a URL on this message board generally requires that the URL be enclosed by the bracketed [ URL ] and [ /URL ] tags. If they aren't enclosed by the bracketed URL tags, then the longer URLs are truncated to 50 character limit and the missing parts of the URL are replaced by three dots: . . . But this causes the URL to become invalid and unreadable.

- - -
FYI, Here are three valid URLs that you can use to replace the three invalid ones in your original post:

https://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=60639#p482969

https://www.practiceupdate.com/content/asco-gi-2018-unselected-patients-with-right-sided-metastatic-colorectal-tumors-experience-worse-disease-free-survival-than-those-with-left-sided-tumors/63276

https://www.researchgate.net/publication/268221060_Is_right-sided_colon_cancer_different_to_left-sided_colorectal_cancer_-_A_systematic_review



THANKS STOMA MIA...YOUR THE BEST!
57/F
DX:(CC) 10/19/16
11/4/16- Lap right hemi(cecum)
CEA- Pre Op (1.9), Pre Chemo (2.5)
Type: Adenocarcinoma
Tumor size:3.5 cm x 2.5 x 0.7 cm
Grade: G3 (path) G2 (pre-op)
TNM: T3N0M0/IIA
LN: 0/24
LVI present
Surgical margins: clear
MSS
12/27/2016 - Capeox, anaphylactic reaction
1/2/17 to 6/9/17- Xeloda
6/17,12/17,6/18,12/18,6/19,12/19,12/20 CT Scan NED :D
CEA- 6/17- 3.6, 9/17- 2.8 12/17-2.8, 3/18-3.1, 6/18-3.0, 9/18 2.8, 12/18 2.5 3/19 3.1 6/19 3.1 9/19 2.6 12/19 2.8 6/20 3.0 12/20 2.7
Clear Colonoscopy 10/17, 11/19 :D


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