sch wrote:Hi Nate,
I managed to complete all 12 rounds of my FOLFOX (5FU, Oxy and folinic acid) treatment
I had a round of FOLFOX every two weeks for 6 months.
However, after the 11th round, I managed to contract an upper respitory infection (thanks to a cold).
This pushed my temperature above a pre-defined level and I had to go to hospital and spend a couple of days there while they used a drip to give me antibiotics.
Honestly, I felt fine, it was just the procedure I had to follow.
A couple of weeks after I got out of hospital, I completed my treatment!
I personally found the side effects of the oxaliplatin worse than the infection, but everyone is different.
Let me know if you have any other questions.
O Stoma Mia wrote:Adjuvant therapy for elderly patients with stage III colon cancer
Evidence summary and recommendationshttps://wiki.cancer.org.au/australia/Clinical_question:Adjuvant_therapy_in_elderly_CRC_patients
In elderly patients (≥ 70 years) following surgery for stage III colon cancer, subset analyses of three randomised controlled trials found no survival benefit from the addition of oxaliplatin to a fluoropyrimidine containing adjuvant chemotherapy (involving either 5-fluorouracil or capecitabine), compared to adjuvant chemotherapy with a fluoropyrimidine alone. , , , 
Elderly patients (≥ 70 years) with stage III colon cancer who are fit for adjuvant chemotherapy should receive 6 months of a single-agent fluoropyrimidine (either 5FU or capecitabine).
The addition of oxaliplatin to adjuvant fluoropyrimidine-based therapy in elderly patients (≥ 70 years) with stage III colon cancer did not improve survival outcomes.
martd wrote:I completed 12 rounds of folfox but reduced the oxi by 50% round 11and eliminated round 12 due to neuropathy. It's very important your dad communicates all side effects to the Onc. Supplements are very helpful but also discuss them with the Dr before taking anything. Stay hydrated, drink lots of fluids before and during chemo.
I was very fortunate and had a complete response to chemo, I've been off treatment now only 10 months but so far so good.
Best of luck to your dad
rp1954 wrote:... But we never used iri-, oxi-, Avastin either - to avoid their usual side effects and compatibility issues while gaining performance from the other, nicer choices... Chemistry doesn't have to be expensive or nasty, it just needs to be right for the particular biology.
Cured wrote:Nate, I am blessed not to need blood products, nor nupegen, and am able to avoid infections when on chemo.
I encourage you and others to do the full FOLFOX regimen. Statistically the Oxaliplatin adds to your life expectancy. The platinum has some misery- neuropathy- but I accept temporary inconvenience in order to stay alive. Here in the Club I have read too many people quitting the treatment due to it being uncomfortable. My FOLFOX was 8 cycles post surgery; which gave me 10 years cancer free. It would have been 12 cycles - but since I had 6 weeks of continuously pumped 5FU while doing daily radiation before surgery, my ONC said 8 cycles adjunct (after surgery mop-up chemo) was enough.
Since my cancer metastisized 10 years later, I had to do more chemo: this time 12 rounds of FOLFIRI. This time the 5FU was accompanied by Irinotecan instead of Oxaliplatin; still with Leucovorin. It was easier to tolerate- no “electrical shock” of fingers nor frying of nerve-endings. Instead I endured diarrhea- which is still better than leaving my family behind.
May God give you the strength to endure the chemo.
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