mhf1986 wrote:DH did 5FU for 12 months and switched to Xeloda. He was on 3000mg a day. Diarrhea for most of the time, peeling hands and feet. Bilirubin went up so the onc delayed treatment for 7 weeks. He has now switched back. Yes, it was nice not carrying around the pump and it was nice going every 3 weeks (for the 3 treatments it lasted) but the side effects were too much.
Each person will react differently!
M
heiders33 wrote:My understanding is that there are two differences between Xeloda and 5FU: 1) Xeloda has more GI effects 2) 5FU gets more quickly into your bloodstream. The advantage of Xeloda is that it’s pills over a pump. My onc said he didn’t see much difference in outcomes between the two, at least in my case. I went with the pills because I had a good response with them during neo-adjuvant. I’ve had very few side effects with Xeloda except a little diahrrea and irritated feet, which may also be the Oxi. What does your onc recommend in your case?
This longitudinal study found that chronic OIPN was present in 94% and 64% of colon cancer patients at the end of oxaliplatin treatment and 1 year after treatment, respectively. The main clinical characteristics of cumulative OIPN were distal numbness and tingling in the fingers and hands/toes and feet, and these symptoms tended to worsen as the cumulative dose of oxaliplatin increased during the 12 FOLFOX treatment cycles. Grade-3 neuropathy was identified in 0, 3, and 14% of patients after 4, 8, and 12 cycles of treatment, respectively. These results are consistent with previous studies finding chemotherapy-induced neuropathy in 80–92% of the patients who were treated with the FOLFOX regimen, in which 8–15% of the neuropathies were grade 3.
NHMike wrote:I try to stay away from kids when I'm on chemo. I don't think that they're allowed in the cancer center at the local hospital (it's a separate area from the general hospital) unless they have a reason to be there (treatment).
mhf1986 wrote:DH did 5FU for 12 months and switched to Xeloda. He was on 3000mg a day. Diarrhea for most of the time, peeling hands and feet. Bilirubin went up so the onc delayed treatment for 7 weeks. He has now switched back. Yes, it was nice not carrying around the pump and it was nice going every 3 weeks (for the 3 treatments it lasted) but the side effects were too much.
Each person will react differently!
M
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