Elevated c-reactive protein (hsCRP) increases risk for rectal cancer recurrence

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lpas
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Joined: Wed Nov 19, 2014 11:11 pm

Elevated c-reactive protein (hsCRP) increases risk for rectal cancer recurrence

Postby lpas » Thu Feb 04, 2016 1:04 pm

I just posted some info about this in a response elsewhere, but thought it was important enough to deserve its own thread. If you haven't already, get your hsCRP checked!! There are lots of things that can be done to lower elevated values.

http://www.ncbi.nlm.nih.gov/pubmed/24222151
11/14 Dx sigmoid CC @ 45yo
12/14 Colectomy + hysterectomy
Stage IIIB, T3N1bM0, 2/20 nodes, MSS, G2, KRAS(A146T), TP53, SMAD4, ERBB2, CEA 1.0
2/15-7/15 XELOX & celecoxib
2/19 clean scope
11/19 clean CT
Ongoing cimetidine & other targeted supplements
Mom to a 6 & 8yo

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NZJay
Posts: 640
Joined: Mon Dec 16, 2013 3:00 pm
Location: NZ

Re: Elevated c-reactive protein (hsCRP) increases risk for rectal cancer recurrence

Postby NZJay » Thu Feb 04, 2016 6:09 pm

Interesting. My cancer was originally detected due to my doctor being suspicious of my moderately above normal, but constantly increasing, CRP
11-13 Dx CC
SPS T4b(touched stomach organ),N1(3/23),M0(Stage 3B)
11-13: resect + partial gastrect
2-14: 1 Tx Cape + Oxy; renal failure, colitis
4-14: 7 Tx Capecitabine
1-15: clear CT
7-15: clear scope
1-16: clear CT
3-17: clear CT
10-17: clear scope (5 year gap now!)
CEA@dx: 8.4 / 6-15: 4.0 / 10-15: 4.2 / 2-16: 4.9 / 7-16: 4.9 / 11-16: 5.0 / 6-17: 4.5
NED since resection

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O Stoma Mia
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Joined: Sat Jun 22, 2013 6:29 am

Re: Elevated c-reactive protein (hsCRP) increases risk for rectal cancer recurrence

Postby O Stoma Mia » Sat Feb 06, 2016 11:21 am

lpas wrote:... If you haven't already, get your hsCRP checked!! There are lots of things that can be done to lower elevated values.
http://www.ncbi.nlm.nih.gov/pubmed/24222151

This is one of the tests recommended by Dr Keith Block in his book, Life Over Cancer, (Chapter 15), as a way of checking on levels of systemic inflammation. Maybe some additional markers of systemic inflammation could be added to your list as well if you are going to go to the trouble of having some special blood work done.
Life over Cancer (2009) Keith Block M.D.

Chapter 15 “Inflammation: Overcoming Cancer’s Feiry Side”pp324-345

15.3.1 Measuring Inflammatory Status
15.3.1.1 C-reactive protein (CRP)
15.3.1.2 Erythrocyte Sedimentation Rate (ESR)
15.3.1.3 Fibrinogen
15.3.1.4 PGE-2 and LTB4 markers
15.3.1.5 Interneukin-6
15.3.1.6 TNF-alpha


lpas
Posts: 1010
Joined: Wed Nov 19, 2014 11:11 pm

Re: Elevated c-reactive protein (hsCRP) increases risk for rectal cancer recurrence

Postby lpas » Sun Feb 07, 2016 7:46 pm

O Stoma Mia wrote:
lpas wrote:... If you haven't already, get your hsCRP checked!! There are lots of things that can be done to lower elevated values.
http://www.ncbi.nlm.nih.gov/pubmed/24222151

This is one of the tests recommended by Dr Keith Block in his book, Life Over Cancer, (Chapter 15), as a way of checking on levels of systemic inflammation. Maybe some additional markers of systemic inflammation could be added to your list as well if you are going to go to the trouble of having some special blood work done.
Life over Cancer (2009) Keith Block M.D.

Chapter 15 “Inflammation: Overcoming Cancer’s Feiry Side”pp324-345

15.3.1 Measuring Inflammatory Status
15.3.1.1 C-reactive protein (CRP)
15.3.1.2 Erythrocyte Sedimentation Rate (ESR)
15.3.1.3 Fibrinogen
15.3.1.4 PGE-2 and LTB4 markers
15.3.1.5 Interneukin-6
15.3.1.6 TNF-alpha



Excellent point, OSM. If you can get all these it would be great. My naturopath tests for most of them, although I suspect a conventional oncologist might balk. Yet another reason why a good naturopath or integrative doctor can be worth their weight in gold.
11/14 Dx sigmoid CC @ 45yo
12/14 Colectomy + hysterectomy
Stage IIIB, T3N1bM0, 2/20 nodes, MSS, G2, KRAS(A146T), TP53, SMAD4, ERBB2, CEA 1.0
2/15-7/15 XELOX & celecoxib
2/19 clean scope
11/19 clean CT
Ongoing cimetidine & other targeted supplements
Mom to a 6 & 8yo

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PGLGreg
Posts: 1427
Joined: Sat Nov 04, 2006 12:38 am
Location: Waimanalo, HI

Re: Elevated c-reactive protein (hsCRP) increases risk for rectal cancer recurrence

Postby PGLGreg » Mon Feb 08, 2016 11:19 am

lpas wrote:There are lots of things that can be done to lower elevated values.

Thanks for the reference, but there is nothing in the abstract to suggest that lowering the CRP would be beneficial.
Greg
stage 2a rectal cancer 11/05 at age 63
LAR 12/05 with adjuvant radiation+5FU,leucovorin 1-2/06
NED for 12 years, cured

lpas
Posts: 1010
Joined: Wed Nov 19, 2014 11:11 pm

Re: Elevated c-reactive protein (hsCRP) increases risk for rectal cancer recurrence

Postby lpas » Mon Feb 08, 2016 1:21 pm

PGLGreg wrote:
lpas wrote:There are lots of things that can be done to lower elevated values.

Thanks for the reference, but there is nothing in the abstract to suggest that lowering the CRP would be beneficial.


Good point, Greg. We all will have different levels of comfort when it comes to experimenting with promising but unproven approaches. Given the many health benefits associated with decreasing systemic inflammation, this one is a gamble I'm willing to take. YMMV
11/14 Dx sigmoid CC @ 45yo
12/14 Colectomy + hysterectomy
Stage IIIB, T3N1bM0, 2/20 nodes, MSS, G2, KRAS(A146T), TP53, SMAD4, ERBB2, CEA 1.0
2/15-7/15 XELOX & celecoxib
2/19 clean scope
11/19 clean CT
Ongoing cimetidine & other targeted supplements
Mom to a 6 & 8yo


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