CLINICAL TRIALS and Important Links

[CRguy]

Dear ColonTalk Forum Members :

We are anchoring this topic to act as an ongoing resource of important links, and as requested, all of our links to Clinical Trials are now being listed here as a permanent index.

The impetus for this was from the topic Clinical Trial Information started by our dear friend lilacbreastedroller,
who sadly, is no longer with us ( lilacbreastedroller has earned her wings )


Please note :

All individual discussions should be started on the regular forum so this topic remains JUST as an index of important links.
It will be curated much like our ongoing 2009- 2016 "In Memoriam" topic and ***News Stories Thread*** ONGOING 2016.

Any member who wishes to post a link here may do so as long as the format is consistent :
Subject = the name of the link or trial
body of the post = an active link to the site or clinical trail and a brief description.

The first listing will be an example, but PM me if you have any problems.

Best wishes all and let's get those links OUT THERE !

Cheers
CRguy

[CRguy]

Cancer Research Institute has posted a list Cancer Immunotherapy Clinical Trials

and an interactive trial finder Here

[CRguy]

Our own member DK37 will update his list of Science Posts HERE
to keep his research investigations current for both basic science as well as new CRC clinical trials.

[Mastan]

Keep up the good work on this important topic.

Thanks,

Mark

[bitchslapped]

STANDARD OF CARE-
National Comprehensive Cancer Network (NCCN):
Downloadable guideline for standard of care
http://www.nccn.org/patients/guidelines ... aspx#colon


Clinical versions are also available here :
https://www.tri-kobe.org/nccn/guideline/colorectal/english/rectal.pdf
https://www.tri-kobe.org/nccn/guideline/colorectal/english/colon.pdf


SUPPORT RESOURCES (financial, travel, lodging, etc)-
Lynch Syndrome International
"Hover" over Resource page (not just for Lynch patients)
http://lynchcancers.com/

Michael's Mission (The Colon Club partner):
http://www.michaelsmission.org/resources-library/

http://www.needhelppayingbills.com/index.html

National Association of Healthcare Advocacy Consultants (private, fee-based personal care management)
http://nahac.memberlodge.com/

Patient Advocate Foundation (free)-
http://www.patientadvocate.org/


CLINICAL TRIALS GLOBAL DATABASE-
CenterWatch
Publishing/information services listing of institutional review board (IRB)-approved clinical trials.
http://www.centerwatch.com/clinical-trials/listings/

U.S. National Institutes of Health (NIH), (private & public sponsored)
https://www.clinicaltrials.gov/

National Cancer Institute (NCI), (U.S., Canada)
http://www.cancer.gov/about-cancer/trea ... als/search


CLINICAL TRIAL MATCH UP SERVICES (phone support)-
Paid by their sponsors/partners @ no cost to the public

American Cancer society (Global)
Partnered w/eviti clinical trial finder database (software for clinicians)
http://www.cancer.org/treatment/treatme ... find-trial

Emergingmed (U.S., Canada) Many websites (including Foundation Medicine/Foundation One) have partnered with this designer of clinical trial finders:
https://www.emergingmed.com/pub_home_page.asp

From our own Colon Club partner Michael's Mission (U.S.)-
http://curelauncher.com/

National Cancer Institute (NCI), (U.S)
Will provide contacts to clinical trial navigators globally
http://www.cancer.gov/contact

[O Stoma Mia]

Why Should I Participate in a Clinical Trial?
http://www.nih.gov/health-information/nih-clinical-research-trials-you/why-should-i-participate-clinical-trial

Benefits and risks of clinical trials

The decision to join a clinical trial is similar to making decisions about other aspects of your treatment. There are both pros and cons associated with clinical trials. Some people decide that there are too many risks, while others decide that they are willing to take those risks to try a new treatment.

Here is how participating in a clinical trial can help you:

You may gain access to new treatments that are not available to the public.
You will get expert medical care at leading health care facilities during the clinical trial.
You will be helping others by contributing to medical research.

Here are some of the potential risks:

There may be side effects from medications or treatments.
The treatment may not work.
The clinical trial may require more of your time for trips to the study site, treatments, hospital stays, or complex dosage requirements than would be required for a standard treatment.
The new treatment may not be available to you right away once the clinical trial is finished.

Reference: Benefits and Risks of Clinical Trials
http://www.cancer.net/navigating-cancer-care/how-cancer-treated/clinical-trials/deciding-participate-clinical-trial

[chrisca]

This one is closed, but worth watching:

The Value of Botox-A for Management of Low Anterior Resection Syndrome
https://www.clinicaltrials.gov/ct2/show/NCT01589471

Looks like they are trying to create a rectosigmoid junction to block the nerve signals from the colon from reaching the neorectum and provide better functioning.

[JFrog]

This is a trial starting soon with an A2A receptor inhibitor that may help PD-L1 work for MSS mCRC. No trial locations listed yet and it will be randomized but it has excellent pre-clinical data/models;

https://www.clinicaltrials.gov/ct2/show ... 016&rank=9

NCT trial number: NCT02655822

[JFrog]

The CPI-444 w/ PD-L1 now recruiting in San Antonio. DK37 posted lots of information on this trial

[Nik Colon]

To conduct clinical trials for the treatment of cancer in a consistent manner across many participating hospitals, cancer centers, and clinics requires the use of standard criteria for measuring how the disease impacts a patient’s daily living abilities (known to physicians and researchers as a patient’s performance status). The ECOG Scale of Performance Status is one such measurement. It describes a patient’s level of functioning in terms of their ability to care for themself, daily activity, and physical ability (walking, working, etc.).

http://ecog-acrin.org/resources/ecog-performance-status

[Nik Colon]

Find a Cancer Mutation
http://www.mycancergenome.org/

[O Stoma Mia]

In the U.S. there is an organization with a website for physicians and patients with very detailed decision trees (flowcharts) to help physicians decide which treatment to start off with. These decision trees require data from the various pathology reports and scan reports. The organization is NCCN (National Comprehensive Cancer Network), and it has separate web pages and separate decision trees for Colon Cancer treatment and Rectal Cancer treatment.

These two types of cancer are treated differently, for the most part because Rectal Cancer often has a chemo/radiation component which Colon Cancer does not usually have. In that sense, Rectal Cancer treatment can be considered more aggressive because it is pursued with both chemo and radiation.

Again, it is important to note that the two domains are different, and the documents consulted by physicians in determining treatment are different. (Of course, they are not totally different. There are cases where certain branches of the decision tree are exactly the same for Colon and for Rectal, but Rectal Cancer has some branches in the decision tree that Colon Cancer does not have.)

When you are consulting with your doctor, it is important to find out which document and which decision tree he/she is following, since the two documents are different and are of different lengths.

• NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Colon Cancer, Version 2.2015, 143pp
  .
• NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Rectal Cancer, Version 1.2015, 114pp

[DK37]

Our own member DK37 will update his list of Science Posts HERE
to keep his research investigations current.

Just to make clear - my Science posts links mentioned in the thread above (and now with their own sticky!) contain both basic science as well as new CRC clinical trials as I find them. So hit the link for clinical trials too!

-DK

[turtle]

Immunotherapy with CEA(6D) VRP Vaccine (AVX701) clinical trial at Duke for patients with Stage III Colorectal Cancer
Link: https://clinicaltrials.gov/ct2/show/NCT01890213?term=CEA%286D%29+VRP+Vaccine+%28AVX701%29&rank=2
A year ago, Duke told me that the clinical trial requires that a patient visit Duke in North Carolina many times, all seasons of the year (you cannot have your non-Duke oncologist do the testing and evaluation). As part of the study, at least one CT scan is done on you.

Instead of calling 919-668-1861 like the clinicaltrials.gov page indicates, you might get information faster by trying to schedule an appointment with Duke's gastrointestinal oncology center. You can be seen by Dr. Michael Morse or one of his colleagues.

ClinicalTrials.gov Identifier:
NCT01890213

[Maia]

NCT02888743
Durvalumab and Tremelimumab With or Without High or Low-Dose Radiation Therapy in Treating Patients With Metastatic Colorectal or Non-small Cell Lung Cancer
https://clinicaltrials.gov/show/NCT02888743

Not yet recruiting. At Dana-Farber - Harvard Cancer Center. Boston, Massachusetts.

All 3 arms receive the 2 immuno drugs: A: two drugs without radiation; B: two drugs with radiation at a low dose; C: B: two drugs with radiation at a higher dose.
Lesion to be radiated has to be in liver.
Only for MSS

(Patients on the CRC arm need to have: "Microbiology Susceptibility Subcategory (MSS) tumor as documented by either:
Immunohistochemistry (IHC) testing that does not suggest loss of MLH-1, MSH-2, PMS2 or MSH6
Polymerase chain reaction (PCR) testing that does not suggest microsatellite instability (MSI))

durvalumab (MEDI4736): anti PD-L1, similar to atezolizumab.
tremelimumab: anti-CTLA-4, similar to ipilimumab.
More about the combination here: (May 2014) viewtopic.php?f=1&t=46727 and (Nov 2015) viewtopic.php?f=1&t=52938