sharijohn wrote:... I am eagerly looking for a promising treatment for my mom. ...How was your experience? What was the response rate? Was it remission response for all patients that showed a response? Any inside on the gene mutations that could potentially benefit from this treatment? My mom is non msi-high stage iv with kras g12v mutation. Any suggestions would be helpful...
Very briefly: My experience is all on my blog (see link in sig.) there were many ups and downs.
Response Rate: They have not published the results yet, since it is an ongoing trial. I have heard of four patients who are experiencing a durable response. There may be more that I don't know of, however.
Gene Mutations: They expect to find a variety of mutations that will work. They're still learning. They attempt to create a treatment with whatever mutations and HLA the patient brings them.
Dr. Yang (who works with Dr. Rosenberg at NIH) has a trial specifically for G12V mutations, if the patient has a particular HLA. That trial info is here
The trial that I did is listed in my sig.
If you'd like to learn about other trials, check out the Clinical Trial Finder
Another great resource is colontown
my blog: Cancer RiotNED since April 2016!
April 2016: lower left lung lobectomy. NED
8 mo. f/u: 1 of 7 tumors progressed.
6 mo. f/u PR
confirmed (Jan 2016)
Jul 2015: NIH TIL trial NCT01174121 NCI/NIH Surgery Branch FAQ
Dec 2014 confirmed stage IV w/bilateral lung mets
FOLFOX + Radiation (bladder)
KRAS G12D :: MSS
dx Sep 2013 @47yo: IIIc T4b N2b MX [bladder invasion, 17/21 lymph nodes]
Married 28 yrs. kids: 24
SE Michigan home schooler, unemployed mechanical engineer, and programmer.