TIL Immunotherapy at NCI

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Claudine
Posts: 680
Joined: Tue Mar 12, 2019 2:41 pm
Location: Montana

Re: TIL Immunotherapy at NCI

Postby Claudine » Thu Apr 28, 2022 8:56 am

That’s fantastic :D
I’m surprised that given the good results, it’s not a more common treatment. Trial was 7 years ago now! Is it only offered in very specific, limited cases?
Wife of Dx 04/18 (51 yo). MSS, KRAS G12A, no primary
Lytic met L4 vertebrae, EBRT 04/18, SBRT 02/19
Resect small intestine 05/18 (no cancer - Crohn's)
Failed adjuvant Xelox ; Folfiri + Avastin 03/19 to 01/20
6.7 cm left adrenal mass 03/19, successful resection 02/20
Multiple small lung nodules (03/19) now gone/calcified
L3-L4-L5 fusion surgery and partial corpectomy 05/20
CEA since 03/19: high 81.1, low 3.2, now 66
MRI 2/11/22: rectal adenocarcinoma pT3 pN0 stage 2A
LAR surgery April 11

prayingforccr
Posts: 317
Joined: Sun Jun 28, 2020 4:44 pm

Re: TIL Immunotherapy at NCI

Postby prayingforccr » Thu Apr 28, 2022 5:47 pm

Claudine wrote:That’s fantastic :D
I’m surprised that given the good results, it’s not a more common treatment. Trial was 7 years ago now! Is it only offered in very specific, limited cases?


Oncologists are more comfortable with a toxic treatment from 1957 that doesnt work.
11/19: colonoscopy
12/19: diagnosed with stage 3 rectal cancer 6+cm tumor
1-3/20: 20 sessions of radiation, mon-fri capecetibine+clinical trial drug m3814
7/20: 8 treatmentsFOLFOX
11/20: Primary tumor had complete response. Possible tumor deposits on latest mri. Biopsy negative for cancer.
5/21: Multiple lung nodules (3-6mm) on ct scan
10/21: md anderson gives me 1 year without treatment/3 years with folfiri/avastin (refused)
3/22 No growth in nodules 6 months…..most showing cavitation.

User avatar
Peregrine
Posts: 41
Joined: Tue Mar 01, 2022 1:18 am

Re: TIL Immunotherapy at NCI

Postby Peregrine » Fri Apr 29, 2022 5:10 am

Hi Celine,

Thanks for the update! It was nice to see your post with that distinctive avatar of yours designed by your children!

For those of you who were not around here back when the news of the success of this trial was first published in the New York Times, The Wall Street Journal and elsewhere, here are links to some of the stories:

https://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=49736&p=447707#p447707

For those who would like a more recent summary of your journey, here is a link to your recent blogpost update:

http://cancerriot.blogspot.com/2022/02/ ... n.html?m=1

For those interested in the scientific details of the TIL clinical trial that you were on, here is a link to that trial:

NCT01174121

prayingforccr
Posts: 317
Joined: Sun Jun 28, 2020 4:44 pm

Re: TIL Immunotherapy at NCI

Postby prayingforccr » Mon May 02, 2022 8:48 pm

Discussing TIL with Dr Formenti tomorrow.

The fact that she scheduled at telehealth is encouraging.

If it’s an option, I’d start tomorrow.
11/19: colonoscopy
12/19: diagnosed with stage 3 rectal cancer 6+cm tumor
1-3/20: 20 sessions of radiation, mon-fri capecetibine+clinical trial drug m3814
7/20: 8 treatmentsFOLFOX
11/20: Primary tumor had complete response. Possible tumor deposits on latest mri. Biopsy negative for cancer.
5/21: Multiple lung nodules (3-6mm) on ct scan
10/21: md anderson gives me 1 year without treatment/3 years with folfiri/avastin (refused)
3/22 No growth in nodules 6 months…..most showing cavitation.

Claudine
Posts: 680
Joined: Tue Mar 12, 2019 2:41 pm
Location: Montana

Re: TIL Immunotherapy at NCI

Postby Claudine » Mon May 02, 2022 9:05 pm

That’s exciting! Please let us know how it goes!
Wife of Dx 04/18 (51 yo). MSS, KRAS G12A, no primary
Lytic met L4 vertebrae, EBRT 04/18, SBRT 02/19
Resect small intestine 05/18 (no cancer - Crohn's)
Failed adjuvant Xelox ; Folfiri + Avastin 03/19 to 01/20
6.7 cm left adrenal mass 03/19, successful resection 02/20
Multiple small lung nodules (03/19) now gone/calcified
L3-L4-L5 fusion surgery and partial corpectomy 05/20
CEA since 03/19: high 81.1, low 3.2, now 66
MRI 2/11/22: rectal adenocarcinoma pT3 pN0 stage 2A
LAR surgery April 11

prayingforccr
Posts: 317
Joined: Sun Jun 28, 2020 4:44 pm

Re: TIL Immunotherapy at NCI

Postby prayingforccr » Fri May 06, 2022 6:11 pm

Claudine wrote:That’s exciting! Please let us know how it goes!


Not appropriate at this time.

Nodules too small to biopsy.

We are all hoping for stable, then remission.

I love Dr Formenti. Love.
11/19: colonoscopy
12/19: diagnosed with stage 3 rectal cancer 6+cm tumor
1-3/20: 20 sessions of radiation, mon-fri capecetibine+clinical trial drug m3814
7/20: 8 treatmentsFOLFOX
11/20: Primary tumor had complete response. Possible tumor deposits on latest mri. Biopsy negative for cancer.
5/21: Multiple lung nodules (3-6mm) on ct scan
10/21: md anderson gives me 1 year without treatment/3 years with folfiri/avastin (refused)
3/22 No growth in nodules 6 months…..most showing cavitation.


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