FDA investigates 'serious risk' of secondary cancer following CAR-T treatment

Please feel free to read, share your thoughts, your stories and connect with others!
Rock_Robster
Posts: 1017
Joined: Thu Oct 25, 2018 5:27 am
Location: Brisbane, Australia

Re: FDA investigates 'serious risk' of secondary cancer following CAR-T treatment

Postby Rock_Robster » Tue Nov 28, 2023 4:43 pm

As a non-American I won’t comment on your last line, but I’m not aware of any conventional cancer treatment that doesn’t cause increased risk of secondary cancer. Of course something to be aware of, but I always say I’ll always take an effective treatment for the cancer I have a 100% chance of having, with a possibly increased risk of another one later.
41M Australia
2018 Dx RC
G2 EMVI LVI, 4 liver mets
pT3N1aM1a Stage IVa MSS NRAS G13R
CEA 14>2>32>16>19>30>140>70
11/18 FOLFOX
3/19 Liver resection
5/19 Pelvic IMRT
7/19 ULAR
8/19 Liver met
8/19 FOLFOX, FOLFOXIRI, FOLFIRI
12/19 Liver resection
NED 2 years
11/21 Liver met, PALN, lung nodules
3/22 PVE, lymphadenectomy, liver SBRT
10/22 PALN SBRT
11/22 Liver mets, peri nodule. Xeloda+Bev
4/23 XELIRI+Bev
9/23 ATRIUM trial
12/23 Modified FOLFIRI+Bev

rp1954
Posts: 1848
Joined: Mon Jun 13, 2011 1:13 am

Re: FDA investigates 'serious risk' of secondary cancer following CAR-T treatment

Postby rp1954 » Tue Nov 28, 2023 11:55 pm

Big pharma overstating benefits and ignoring side effects and negative data. Who would of thought?

However, I'm not sure that it even counts as a Faustian bargain for 2nd and 3rd line patients, rather "just" a reduction in benefits, unless the long term effect is even uglier than the original spiral down and out.

My biggest question is whether some of the supplements and generic drugs could eliminate or control some of the early secondary cancer cell lines, because there are clear cases and series of lab experiments where vitamin C and/or K2 bought time or remissions in established leukemias. (but not too soon if there is interaction with the CAR-T treatment itself and generic)

Rock_Robster wrote:but I’m not aware of any conventional cancer treatment that doesn’t cause increased risk of secondary cancer.

This even applies to scans with Xrays and PET-FDG, and other effects for contrasts.

However there are huge differences between families of chemo for cancer risk e.g. 5FU is not nearly as bad as some others. This actually came up with blood monitoring for my wife where chemo activity indication of increased chemo-cancer inhibition effectiveness correlated with increased secondary cancer risk 3 years later for some Pt combination drugs for other cancers (but not 5FU). e.g. screaming down the race track at 126, "more chemo" and better, when other drugs crater you later at 115...
watchful, active researcher and caregiver for stage IVb/c CC. surgeries 4/10 sigmoid etc & 5/11 para-aortic LN cluster; 8 yrs immuno-Chemo for mCRC; now no chemo
most of 2010 Life Extension recommendations and possibilities + more, some (much) higher, peaking ~2011-12, taper chemo to almost nothing mid 2018, IV C-->2021. Now supplements

skimom
Posts: 69
Joined: Fri Mar 17, 2023 12:24 pm
Location: Oregon USA

Re: FDA investigates 'serious risk' of secondary cancer following CAR-T treatment

Postby skimom » Wed Nov 29, 2023 11:06 am

prayingforccr wrote:“ The FDA said it had received reports of T-cell malignancies, which refer to a group of blood disorders including lymphomas and leukemias, after treatment with CAR-T therapies or chimeric antigen receptor T-cell therapies.”


Oh no! Will this effect the trial you are on? Of course a government agency would find reason to stop something that is actually working… smh… awful
47yo F at DX
DX 12/11/22 Stage IV (liver & lung mets) KRAS PIK3CA
12/15/22 Primary tumor removed from Transverse Colon (4.3x4.0x0.6cm G2 3/15 lymph nodes. Clear margins)
01/06/23 started Folfox (10 cycles)
Initial CEA 5608
CEA after 4 rounds 1319
CEA after 6 rounds 427
CEA after 9 rounds 95
HAI pump installed 06/20/23
Start FOLFIRI and FUDR 07/05/23
CEA down to 37
31
21
18
9/2023 Switch back to FOLFOX due to new lung nodules
11/23 FOLFOX fail CEA up to 62


Return to “Colon Talk - Colon cancer (colorectal cancer) support forum”



Who is online

Users browsing this forum: No registered users and 6 guests