My hair thinned and turned white (from white/grey) on FOLFOX. It was full before therapy (though full for a 55-yr. old, not full for a 18-yr.-old). There was lots in the comb during treatment, but I never went bald or even close. After chemo it came back to former thickness, perhaps thicker, and (weirdly) came back as black (with some grey). Very odd.
I get the impression this is a YMMV effect.
FOLFOX/Oxaliplatin has some significant side effects. For me the big ones were difficulty holding/touching cold things (not too bad, tolerable, but used gloves when reaching into the freezer), first-bite sensation (pain near salivary glands (sides of face) when first eating (really painful but lasts only seconds), general fatigue, crazy liver enzymes, really low WBC counts (Neulasta helped 100%). I had a lot of arrhythmias as well (not sure if from 5-FU or Oxi or both, but determined to be benign). Really unpleasant GI stuff (no nausea or diarrhea, but just general
“Yuck” feeling often). Eventually you may get numbness, tingling, or pain in hands or feet (neuropathy). That’s generally regarded as the dose limiting side effect.
That’s what I recall for now. It wasn’t as bad as it sounds (most days, anyway : )
7/19: Rectal cancer: Staged as IIIA, T2N1M0
approx 4.25 cm, low/mid rectum, mod. well diff.
8/22 -10/14 4 rounds FOLFOX neoadjuvant, 3 w/Oxiplatin (side effects/reduced size est. 70-75%)
neoadjuvant chemorad 11/19
4 rounds of FOLFOX July-August 2020
ncCR found 10/20; biopsies negative
TAE 11/20, small amount of tumor removed, lung nodules orig id’d 6/20 stable Nov 2020
Chest CT 3/30/21 small growth in 2 nodules (3 and 5mm)
VATS 12/8/21 to remove sub-pleural met 7mm. Considering SBRT for remaining nodule.