Sloan Clinical Trial

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saltygirl
Posts: 34
Joined: Sun Feb 07, 2021 4:46 pm
Facebook Username: Salty.girl

Sloan Clinical Trial

Postby saltygirl » Mon Jun 21, 2021 10:01 pm

I wonder what clinical trial at Sloan. Any idea?
https://www.everydayhealth.com/cancer/c ... al-cancer/

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Green Tea
Posts: 421
Joined: Mon Oct 24, 2016 10:48 am

Re: Sloan Clinical Trial

Postby Green Tea » Tue Jun 22, 2021 12:27 am

saltygirl wrote:I wonder what clinical trial at Sloan. Any idea?
https://www.everydayhealth.com/cancer/c ... al-cancer/

...Before she started chemotherapy at Memorial Sloan Kettering Cancer Center, Spill’s doctors tested her tumor for a mutation that would qualify her for a clinical trial of an immunotherapy drug the center was overseeing.

It was positive. Spill became the fourth person in the United States to try the therapy, which has far fewer side effects than traditional radiation and chemotherapy, and it preserved her ability to conceive in the future.

She was scheduled for nine treatments over the course of six months. By her fourth, the tumor had shrunk by half. It was then that her doctor told her that the therapy had completely cleared the tumors in the three other women enrolled in the trial. By the final treatment, her tumor had completely disappeared..."
https://www.everydayhealth.com/cancer/colon-cancer/why-are-more-and-more-young-people-being-diagnosed-with-colorectal-cancer/

I have no idea which mutation or which immunotherapy product they are referring to. There are over 300 colorectal cancer clinical trials (past and present) listed for Memorial Sloan-Kettering. Here is one clinical trial for patients with BRAF mutation V600E, but MSKCC has not yet started recruiting its patients for this one. It uses the immunotherapy drug Encorafenib. But there are other immunotherapy clinical trials at Memorial Sloan-Kettering that are now open and recruiting patients. You need to know which mutation you are interested in if you are going to search the clinical trials database.

https://clinicaltrials.gov/ct2/show/NCT04607421/

catstaff
Posts: 102
Joined: Wed Mar 03, 2021 11:37 am

Re: Sloan Clinical Trial

Postby catstaff » Tue Jun 22, 2021 9:49 am

High probability she was MMR deficient. I didn't find a date on the article either, so it could have been a while ago.
D/H Dx 10/2019 RC age 61
Clinical T4bN2M1a (common iliac and para-aortic lymph nodes)
MSS KRAS G12D
CRT 11/19-1/20 FOLFOX 3/20-7/20
Pelvic exenteration w/LAR 8/20
ypT4bN0Mx G3 0/14 nodes LVI not seen PNI-
CEA 10/19:20, 1/20-11/20:1.6, 4.3, 3.4, 2.7, 2/21:9.0 3/21:18,40 4/21:28,19, 5/21:13.3,8.6
PET 3/21 recurrence in distal nodes, L5 vertebra, pelvis
FOLFIRI+bev 3/21-

saltygirl
Posts: 34
Joined: Sun Feb 07, 2021 4:46 pm
Facebook Username: Salty.girl

Re: Sloan Clinical Trial

Postby saltygirl » Wed Jun 23, 2021 11:06 am

Thank you both! It’s interesting to learn more.


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