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by Ron-guteleute
Wed Nov 23, 2022 12:16 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Signet Ring Cell Carcinoma + Malignant Ascites, T4N3Mx - Looking for feedback
Replies: 25
Views: 2541

Re: Signet Ring Cell Carcinoma + Malignant Ascites, T4N3Mx - Looking for feedback

Thank you Peregrine. My dad had the portacath placed yesterday, and he will start on Tuesday FOLFOX+Cetuximab, (biomarkers resulted KRAS/NRAS wild type, a full panel of biomarkers is still in process). In light of current events, the Monday's ultrasound revealed bladder wall thickening. The urologis...
by Ron-guteleute
Mon Nov 14, 2022 3:41 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Signet Ring Cell Carcinoma + Malignant Ascites, T4N3Mx - Looking for feedback
Replies: 25
Views: 2541

Re: Signet Ring Cell Carcinoma + Malignant Ascites, T4N3Mx - Looking for feedback

Unfortunately, placing a port-a-cath was not possible because my dad's blood INR was pretty high (1.61) and he could be at high risk of hematomas. His oncologist was not sure about using a PICC line or Midline, therefore the oncologist decided to go for CAPOX/XELOX. She said both FOLFOX and CAPOX ha...
by Ron-guteleute
Mon Nov 14, 2022 3:37 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Signet Ring Cell Carcinoma + Malignant Ascites, T4N3Mx - Looking for feedback
Replies: 25
Views: 2541

Re: Signet Ring Cell Carcinoma + Malignant Ascites, T4N3Mx - Looking for feedback

Ron - It's good that you're getting some second opinions from Comprehensive Cancer Centers. Hopefully you will get some good information that will help specify the best way forward. Please let us know what you find out. I've got some feedback from the Tumor Board (after reviewing all the docs, CT a...
by Ron-guteleute
Fri Oct 28, 2022 1:10 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Signet Ring Cell Carcinoma + Malignant Ascites, T4N3Mx - Looking for feedback
Replies: 25
Views: 2541

Re: Removal of ileocecal valve ?

Another question: Did they remove the ileocecal valve when they did the extended right hemicolectomy? If so, other digestive problems are likely to emerge and require specialized treatments. Permanent SIBO due to removal of ileocecal valve https://connect.mayoclinic.org/discussion/permanent-sibo-du...
by Ron-guteleute
Fri Oct 28, 2022 1:07 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Signet Ring Cell Carcinoma + Malignant Ascites, T4N3Mx - Looking for feedback
Replies: 25
Views: 2541

Re: Special procedures for dealing with mCRC mets to the peritoneum

Ron - In case the malignant pelvic ascites actually become peritoneal mets, here are some references to procedures for dealing with peritoneal mets: Special procedures for dealing with mCRC mets to the peritoneum Pressurized Intraperitoneal Aerosolized Chemotherapy (PIPAC) https://www.webmd.com/can...
by Ron-guteleute
Thu Oct 27, 2022 1:06 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Signet Ring Cell Carcinoma + Malignant Ascites, T4N3Mx - Looking for feedback
Replies: 25
Views: 2541

Re: Signet Ring Cell Carcinoma + Malignant Ascites, T4N3Mx - Looking for feedback

9. P.P.S - Have you discussed the possibility that your father's type of SRCC might be hereditary? Have you yourself been tested for the CDH1 gene mutation? https://www.mskcc.org/news/6-things-know-about-cdh1-gene-mutation-and-stomach That's interesting, I remember coming across this article 3 year...
by Ron-guteleute
Thu Oct 27, 2022 12:59 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Signet Ring Cell Carcinoma + Malignant Ascites, T4N3Mx - Looking for feedback
Replies: 25
Views: 2541

Re: Signet Ring Cell Carcinoma + Malignant Ascites, T4N3Mx - Looking for feedback

Ron -- As everybody has mentioned so far, time is of the essence right now. It's important to act quickly and do something effective now before things get really out of control. But you need to have good advice to begin with. How are you doing on finding good doctors and good cancer hospitals near ...
by Ron-guteleute
Mon Oct 24, 2022 11:20 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Signet Ring Cell Carcinoma + Malignant Ascites, T4N3Mx - Looking for feedback
Replies: 25
Views: 2541

Re: Signet Ring Cell Carcinoma + Malignant Ascites, T4N3Mx - Looking for feedback

Hi R. I'm sorry about your father's situation. There's no way of hiding it, it's bad. I am one of the lucky few SRCC. We make as rp said 1% of CRC, so there's very, very little data on our specific subtype. ... RP gave you some good advice, I can add a couple. Get an NCI accredited center. Get seco...
by Ron-guteleute
Mon Oct 24, 2022 11:10 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Signet Ring Cell Carcinoma + Malignant Ascites, T4N3Mx - Looking for feedback
Replies: 25
Views: 2541

Re: Signet Ring Cell Carcinoma + Malignant Ascites, T4N3Mx - Looking for feedback

What you need to do is achieve some combination of chemical components that slow or kill SRCC cells in various locations, the more locations the better, AND try to improve/preserve immune function and quality of life. You've got several possible directions 1. Collect several conventional recommenda...
by Ron-guteleute
Sat Oct 22, 2022 4:57 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Signet Ring Cell Carcinoma + Malignant Ascites, T4N3Mx - Looking for feedback
Replies: 25
Views: 2541

Signet Ring Cell Carcinoma + Malignant Ascites, T4N3Mx - Looking for feedback

Hello everyone, my father was diagnosed with Signet Ring Cell Carcinoma of the colon (pathology of the tissue T4N3Mx) and malignant asites. The tumor (8cm) was located in cecum near the ileocecal valave. 6 of 16 LN came back positive, including the distant superior mesenteric LN. He had an extended ...

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