Update on trial NCT04553692- IGM8444 Started July 23 Antibody drug plus folfiri and avastin Cea 27.9 July 8.3 August 4.8 sept 4.4. Sept 3.7. Oct 4.0. Nov 3.7. Dec 3.0. Jan Reduction in liver met, lung nodules. -35.8% from baseline to now. I feel most of this response is from chemo, hard to tell what...

I have found that no specific food triggered lars. Some days the same food you’ve eaten with no issues causes you issues. I had the lars managed very well after two months reversal with the addition of Metamucil and Imodium before each meal and limiting eating after 5 pm. There were days of intermit...

Super great news! Think about the positive now. You probably already know this so reminder that walking and a spirometer def helps get lung function back quickly. This will be my second vats IF all goes “well” The first one banged me up for about a month, but all things considered, wasn’t a big dea...

My husband is hoping to get into a bot/bal trial next, now that folfiri and panitumumab have run their course. I’ll update on here if he gets into one. Hate that it is random and he could end up being assigned to a standard of care line. Hi Bpaint, It seems like some people are seeing results on th...

Thank you for the input praying for ccr. I guess I’m comparing the results I got with folfox after 4 treatments last year. I thought with the addition of avastin and this antibody trial drug there would be more shrinkage. I get how you were done with more soc chemo. Folfiri is very rough with radiat...

First scan results after 3 treatments CEA - 27 to 4.8 Liver met - 2.4 from 3.2 cm Lung nodules. All reduced. 8mm- 4mm, 6mm-3mm (Thought there were 6. 3 original at diagnosis. Which hadn’t changed , 3 new ones) Not certain of this is a good result. I’m classified as stable for trial purposes as mine ...

I’m sure this is a stupid question: is p53 mutation the same as a tp53 mutation?

L0729 - I think you mentioned earlier that your regular oncologist was recommending Guardant Testing for you. Is periodic Guardant monitoring "at every step of the treatment journey" still in effect now that your treatment is being monitored by the IGM-4888 clinical trials oncologist? I p...

Hi all, curious if anyone has any experience with the RELATIVITY-123 trial? My onc is keen for me to give it a go. Phase 3, combination fixed-dose relatlimab/nivolumab, with Lonsurf or rego as control arm. I understand this is an established therapy for metastatic melanoma, and they’re looking to u...

... I like to look ahead at what other possible trials to do if I’m able down the line... . Your tumor had a RAD52D mutation, which is linked to a hereditary condition called "HR- deficiency" : " Homologous recombination (HR) is a vital process for repairing DNA double-strand breaks....

Are you going to start a clinical trial this month? [/list][/quote] I started the IGM8444 antibody trial last week and did receive the treatment arm of this trial along with folfiri/avastin. I like to look ahead at what other possible trials to do if I’m able down the line. The oncologist running th...

Clinical trial NCT05608044
Has anyone joined the clinical trial for botensilimab/balstilimab? Curious of any feedback, believe it is in phase2. eligibility requirement of No liver Met involvement at this time, so I would not be able to do this but looks interesting.

IGM-8444 Overview https://igmbio.com/pipeline/igm-8444 . IGM Biosciences Announces Update on IGM-8444 Phase 1 Trial and Future Clinical Development (June 2, 2023) https://investor.igmbio.com/static-files/4564168a-cb65-433b-9cf2-bc82839b0225 . Expanded Access IGM Biosciences recognizes that some pati...

This trial has two possible dose levels, 3mg/kg and 10mg/kg. I don't know why they are putting you on 3m/kg. I did confirm today that it will be a 3mg/kg dose. That will not change. I will inquire about a 10 mg/kg dosing. I thought I was told that subsequent trials with this drug will include the e...

[*] Drug name [*] Dosage to be administered** [*] Sequence in which the drug is to be administered (i.e., 1st, 2nd, 3rd, 4th, or 5th) [*] Expected length of time for this infusion segment There are two reasons for doing this: [list] [*] The IGM-4888 drug is highly dose-dependent , and you need to k...