I don't think anything has come out for preliminary results of these pan-KRAS inhibitors. Supposedly they also have specific KRAS inhibitors, as does Mirati, but those are all currently for G12C which is mainly seen in lung cancer, and is fairly rare in colorectal. Mirati supposedly has a G12D one ...

Thanks for the reply catstaff! I am not a biochemist but I would go with the PCR also. IHC attempts to detect proteins by using antibodies. But if the antibody is not completely specific to the variant, there could be errors. If they get a good genome sample, however, that should be definitive. Than...

Hi all, I firstly wanted to thank the community here. I'm posting for the first time, but I visit frequently to read about your experiences. It's been really helpful to gain knowledge and get some highly needed solidarity. My dad's a metastatic rectal cancer patient. Chemo was pretty effective in th...