Trying wrote:Did you guys who had growth during the break find chemo went back to working again afterwords.
Additionally, maintenance chemotherapy can be given without negatively impacting overall survival. The first progression is probably sooner with the chemotherapy-free interval, says Mahipal. However, when the therapy is reinstituted and is followed by a second progression, patients tend to have the same outcomes whether maintenance therapy was given or if they were continued on the same aggressive regimen.
Rock_Robster wrote:Thanks Pyro70, I agree there definitely seems to be a trend toward ‘less is more’, esp. when oxaliplatin is involved. My onc is suggesting I stop at 8-9 FOLFOX treatments, and no need for further adjuvant oxy if NED after last surgery (maybe a few rounds of 5FU). He believes the evidence for 12 full FOLFOX doses is pretty weak, as it is for adjuvant chemo - provided the chemo was done at some point (and the earlier the better).
Interestingly that article you linked suggests dose reduction is less detrimental to outcomes than complete breaks - seems consistent with a lot of the European work on metronomic chemo too.
One question - what do people interpret as “maintenance chemo” in this context? Is this just a lower-dose chemo designed to delay progression but not necessarily achieve shrinkage? Or is it only chemo given once NED to reduce recurrence risk?
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