Switching back to Pembro

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henry123
Posts: 209
Joined: Sun Oct 08, 2017 3:25 am

Re: Switching back to Pembro

Postby henry123 » Mon Sep 23, 2019 12:54 am

Month 27 .
Infusion every six weeks.
CEA under control.
Have started some non-vegan foods.
Still taking aspirin and continuing with juicing.
46yo M msi-high Lynch +ve
5/16 lap AR 14/21 L nodes +ve
T4N2M1
7/16 Capox 9 cyc
9/16 cea 2
1/17 550
PET CT mets in lung & peri
iri+ avast fail
3/17 10577
4/17 regro fail
5/17 cea 28800
5/17 CT inc in size of mes nodes ,onset of multi nodules in liver
6/17 Opdivo start
7/17 26754
8/17 5623
9/17 497
10/17 52
11/17 12
CT all clear exc a nodule in Lung. liver norm
1/18 3.6
4/18 2
Aspirin start
6/18 1.5 CT clear
12/18 1.1 NED
6/19 .9 CT clear
1/20 NED Opdivo stop

Rock_Robster
Posts: 495
Joined: Thu Oct 25, 2018 5:27 am
Location: Melbourne, Australia

Re: Switching back to Pembro

Postby Rock_Robster » Mon Sep 23, 2019 3:06 am

henry123 wrote:Month 27 .
Infusion every six weeks.
CEA under control.
Have started some non-vegan foods.
Still taking aspirin and continuing with juicing.

Outstanding Henry, well done and thanks for the update. Although I’m not MSI-H, your signature was one of the ones that motivated me in the early tough days.

Cheers
Rob
Male 38; Australia
10/2018 Dx 3.5cm RC adenocarcinoma, 12cm from AV
Mod diff, EMVI+ LVI+. 4 liver mets
pT3N1aM1a; Stage IVa. MSS, NRAS (G13R)
CEA: Oct-18= 12; Nov-18= 14, Mar-19= 2.4, Aug-19 <2.0, Mar-20=2.2, May-20=1.9.
11/18 FOLFOX x6
3/19 Liver resection
5/19 25x pelvic VMAT radiation; complete metabolic response
07/19 ULAR (robot), temp ileo, 1/27 LN
08/19 Missed a liver spot
08-11/19 FOLFOX x1, FOLFOXIRI x1, FOLFIRI x5
12/19 Liver resection #2
02/20 Ileostomy reversed
03/20 PET & MRI = NED!

User avatar
henry123
Posts: 209
Joined: Sun Oct 08, 2017 3:25 am

Re: Switching back to Pembro

Postby henry123 » Mon Sep 23, 2019 3:57 am

Rock_Robster wrote:
henry123 wrote:Month 27 .
Infusion every six weeks.
CEA under control.
Have started some non-vegan foods.
Still taking aspirin and continuing with juicing.

Outstanding Henry, well done and thanks for the update. Although I’m not MSI-H, your signature was one of the ones that motivated me in the early tough days.

Cheers
Rob

Best Wishes, Rob
46yo M msi-high Lynch +ve
5/16 lap AR 14/21 L nodes +ve
T4N2M1
7/16 Capox 9 cyc
9/16 cea 2
1/17 550
PET CT mets in lung & peri
iri+ avast fail
3/17 10577
4/17 regro fail
5/17 cea 28800
5/17 CT inc in size of mes nodes ,onset of multi nodules in liver
6/17 Opdivo start
7/17 26754
8/17 5623
9/17 497
10/17 52
11/17 12
CT all clear exc a nodule in Lung. liver norm
1/18 3.6
4/18 2
Aspirin start
6/18 1.5 CT clear
12/18 1.1 NED
6/19 .9 CT clear
1/20 NED Opdivo stop

User avatar
henry123
Posts: 209
Joined: Sun Oct 08, 2017 3:25 am

Re: Switching back to Pembro

Postby henry123 » Wed Feb 05, 2020 11:36 pm

Finally after almost 3 years of immunotherapy and 2 years of clear CT and blood work , the onco team has decided to stop further infusions.
It is still largely an uncharted territory but some data has emerged to suggest that it is time to remove the immunotherapy life jacket .
Tighter monitoring regime for a year.
A bit scary but I guess you have to stop at some point.
Have to focus on a healthy lifestyle and stress-free mindset.
My wife and daughter are a bit freaked out but that's understandable.
46yo M msi-high Lynch +ve
5/16 lap AR 14/21 L nodes +ve
T4N2M1
7/16 Capox 9 cyc
9/16 cea 2
1/17 550
PET CT mets in lung & peri
iri+ avast fail
3/17 10577
4/17 regro fail
5/17 cea 28800
5/17 CT inc in size of mes nodes ,onset of multi nodules in liver
6/17 Opdivo start
7/17 26754
8/17 5623
9/17 497
10/17 52
11/17 12
CT all clear exc a nodule in Lung. liver norm
1/18 3.6
4/18 2
Aspirin start
6/18 1.5 CT clear
12/18 1.1 NED
6/19 .9 CT clear
1/20 NED Opdivo stop

plastikos
Posts: 339
Joined: Wed Jan 14, 2015 6:09 am

Re: Switching back to Pembro

Postby plastikos » Sun Mar 15, 2020 11:20 am

henry123 wrote:Finally after almost 3 years of immunotherapy and 2 years of clear CT and blood work , the onco team has decided to stop further infusions.
It is still largely an uncharted territory but some data has emerged to suggest that it is time to remove the immunotherapy life jacket .
Tighter monitoring regime for a year.
A bit scary but I guess you have to stop at some point.
Have to focus on a healthy lifestyle and stress-free mindset.
My wife and daughter are a bit freaked out but that's understandable.

Super happy to hear this. I too hopefully am about to take this leap to stop further infusions. Scary but yes it has stop at some point.
St. IV Colon CA @ 37, male, Kras wild, MSI-high (2014)
11/2014 Right Hemicolectomy + Liver Resection
12/2014 - 6/2015 FOLFOX + Cetuximab
10/2015 - Recurrence liver
Liver resection 10/2015
FOLFIRI 11/2015 - 5/2016
Recurrence liver, nodes 11/2016
Pembrolizumab started 12/2016 -> pseudoprogression(?) -> biliary obstruction -> biliary stenting
Chemo 4x: most mets inactive and smaller on PET-CT
March 2017 - Back on Pembrolizumab again
Sept 2017 - SIRT - > NED
2019 NED

stu
Posts: 1343
Joined: Sat Aug 17, 2013 5:46 pm

Re: Switching back to Pembro

Postby stu » Sun Mar 15, 2020 1:32 pm

Wishing you both every success .
Stu
supporter to my mum who lives a great life despite a difficult diagnosis
stage4 2009 significant spread to liver
2010 colon /liver resection
chemo following recurrence
73% of liver removed
enjoying life treatment free
2016 lung resection
Oct 2017 nice clear scan . Two lung nodules disappeared
Oct 2018. Another clear scan .


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