Can chemo increase ALT & AST

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teresajj1
Posts: 42
Joined: Sun Mar 27, 2016 7:36 pm
Location: Florida

Can chemo increase ALT & AST

Postby teresajj1 » Sun Dec 22, 2019 12:04 pm

Hey everybody. It's been awhile since I've posted. Im on 5FU (3rd round) and my AST and ALT numbers increased and I'm a bit worried. Although I am Stage 4, I've not yet had any cancer in my liver. It always comes back in my belly or pelvic area. This increase concerns me that something is wrong with my liver. Has anyone had an increase in these numbers while on chemo? I plan to ask my oncologist, but won't see him again until after Christmas.

Thanks, Teresa
Dx 3/16 @ 36yrs Stage IIIB
RT Hemi-colectomy
T3N1M0. 2/37 lymph nodes
4/2016 Started 12 rounds of 5 FU & Oxi Chemo
7/2016 Stopped chemo after 5 rounds due to chest pain
8/2017 MUYTH Gene
10/2017 Clear CT Scan; CEA 1.9
5/2018 CEA 447
6/2018 Stage IV w/drop metastases to peritoneal cavity
7/2018 Cytoreductive surgery & Hipec (3 tumors, 2 nodules on bladder, and ovaries removed)
05/2019 Clear CT
10/2019 2 new nodules in pelvic area/CEA 19
11/2019 6 Rounds of Chemo

Punky44
Posts: 446
Joined: Mon Oct 01, 2018 4:29 pm

Re: Can chemo increase ALT & AST

Postby Punky44 » Sun Dec 22, 2019 12:16 pm

Yes, this happened to my mom while on chemo and then they went down. I posted about it here:

viewtopic.php?f=1&t=61486&p=486249#p486249
Caregiver to my amazing mom (68 at dx)
10/1/18 DX with rectal cancer; CEA 17
T3N2M0
Total neoadjuvant therapy:
8 rounds Folfox 11/5/18 - 2/11/19
Short course radiation 3/14/19 - 3/20/19
Robotically assisted laparoscopic LAR 3/21/19
Pathology report says yT2N0M0 with 0/38 nodes
6/28/19 Reversal and port out
CEA 2.1; 1.9; 2.6; 2.8; 2.3; 2.4
Latest update: 6/20–Clear CT; 9/22—CEA 2.4

Me: 34, first colonoscopy 11/16/18—normal! Come back in 5 years.

teresajj1
Posts: 42
Joined: Sun Mar 27, 2016 7:36 pm
Location: Florida

Re: Can chemo increase ALT & AST

Postby teresajj1 » Sun Dec 22, 2019 12:19 pm

Oh thank goodness!
Dx 3/16 @ 36yrs Stage IIIB
RT Hemi-colectomy
T3N1M0. 2/37 lymph nodes
4/2016 Started 12 rounds of 5 FU & Oxi Chemo
7/2016 Stopped chemo after 5 rounds due to chest pain
8/2017 MUYTH Gene
10/2017 Clear CT Scan; CEA 1.9
5/2018 CEA 447
6/2018 Stage IV w/drop metastases to peritoneal cavity
7/2018 Cytoreductive surgery & Hipec (3 tumors, 2 nodules on bladder, and ovaries removed)
05/2019 Clear CT
10/2019 2 new nodules in pelvic area/CEA 19
11/2019 6 Rounds of Chemo

Rock_Robster
Posts: 517
Joined: Thu Oct 25, 2018 5:27 am
Location: Melbourne, Australia

Re: Can chemo increase ALT & AST

Postby Rock_Robster » Mon Dec 23, 2019 6:08 am

Absolutely! I got to over 500 ALT and 300 AST, and they recovered fine without issues. My oncologist was happy to keep treating throughout. The chemo nurses said the “normal” ranges on the pathology reports don’t really apply to chemo patients... :)

Rob
38M Australia
10/2018 Dx RC, 12cm high
Mod diff, EMVI+ LVI+. 4 liver mets
pT3N1aM1a Stage IVa. MSS NRAS G13R
CEA: Oct-18= 12; Nov-18= 14, Mar-19= 2.4, Aug-19 <2.0, Mar-20=2.2, May-20=1.9, Jun-20=2.1, Sep-20: 2.1
11/18 FOLFOX x6
3/19 Liver resect
5/19 25x pelvic radiation; complete met. response
07/19 ULAR w ileo, 1/27 LN+
08/19 Found liver spot
08/19 FOLFOX x1, FOLFOXIRI x1, FOLFIRI x5
12/19 Liver resect
02/20 Ileo reversed
03/20 NED (PET+MRI)
06/20 NED (CT+MRI)
07/20 Clear scope
09/20 NED (PET)

Deb m
Posts: 558
Joined: Tue Jan 14, 2014 10:08 am

Re: Can chemo increase ALT & AST

Postby Deb m » Mon Dec 23, 2019 9:12 am

Yes. My husbands ALT was high towards the end of his chemo, went back down a few months after completing treatments. Remember is really poison going into you system and after a while, your liver starts to talk to you.

User avatar
juliej
Posts: 3114
Joined: Thu Aug 05, 2010 12:59 pm

Re: Can chemo increase ALT & AST

Postby juliej » Thu Dec 26, 2019 6:09 pm

Deb m wrote:Remember is really poison going into you system and after a while, your liver starts to talk to you.

Me: Here's some nice Folfox for you. Yum!

My liver:@#$%&*!!!

Me: I know, but the doctors say it's gooood for you. It'll make you well! Really! (fingers crossed behind back)

My liver: That [explictive deleted] stuff is [explictive deleted] hard on me! My AST is up. My ALT is up. My Alk Phos is up. Are you sure this isn't killing me?

Me: Uh... it's killing the tumors. And, well, maybe causing a few problems for you too, but you can handle it, right?

My liver: @#$%&*!!!

Me: Gotta run. Talk later.
Stage IVb, liver/lung mets 8/4/2010
Xelox+Avastin 8/18/10 to 10/21/2011
LAR, liver resec, HAI pump 11/2011
Adjuvant Irinotecan + FUDR
Double lung surgery + ileo reversal 2/2012
Adjuvant FUDR + Xeloda
VATS rt. lung 12/2012 - benign granuloma!
VATS left lung 11/2013
NED 11/22/13 to 12/18/2019, CEA<1

Deb m
Posts: 558
Joined: Tue Jan 14, 2014 10:08 am

Re: Can chemo increase ALT & AST

Postby Deb m » Fri Dec 27, 2019 12:22 pm

Julie,

I always teased my husband when he was going thru folfox in saying that if this doesn't work, well just go home and have you drink some week killer. That might kill the tumor and hopefully not you!


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