KRAS and MSS

[SilverWedding]

Everything I read says that this is a bad combo with a worse survival rate.

1. Are there any KRAS/MSS success stories to give hope?

2. Also, given this new finding, should we move out of our local can we Center and into the care of a higher level one?

3. FOLFOX starts next week. I hope that sounds right.

We need good news. I love my husband so much, and I hate this.

Thank you,
Cynthia

[AlexandraZ]

Isn't your husband stage III? I might be wrong, but I really don't think it makes that much of a difference in that case. If you want, you can google Stacy Hurt and read her story. She was a stage 4B patient with KRAS mutation and MSS and she's been NED for years.

For what it's worth, I'd trade my boyfriend's stage 4B for a Stage III with KRAS mutation any day!

[fumaros]

You need to stay hopeful. Many brilliant scientist are working on targeting KRAS mutations, and some pharamceutical company have drugs currently under clinical trial with positive results. You can read this article (https://www.fiercebiotech.com/research/ ... ers-clinic).

Stay as healthy as one can for as long they can, and the arc of progress will eventually find a drug that will work. Even on current treatment regimens, colon cancer patients are living longer than ever before.

[claudine]

Yes! Fumaros said it all. Cancer research is moving by leaps and bounds... And like Alexandraz noted, your husband is stage 3. I understand what a shock the diagnosis is (went through that) but try to stay positive XXX

[claudine]

Also thanks for the link, Fumaros. My husband is G12A, which apparently is only 6% of KRAS mutations, so anything that targets KRAS in general is good news! I guess with his absence of primary and relatively uncommon mets, he just can't do anything like the rest of the world

[NHMike]

I'm KRAS G12D, probably the most common mutation in Colorectal Cancer. Stage is 3B, same as your husband. I was diagnosed 2.5 years ago and am still around. I'm currently in the state of No Evidence of Disease. Survival stats are 71% (5-year) but this has improved considerably over the past ten years and, obviously, the number is five years old.

[SilverWedding]

Everyone - Thank you for giving me hope and putting things into perspective.

It’s just so upsetting, and it seems we keep losing ground. Your advice and success stories are a big key to my optimism. Thank you.

Cynthia

[Jacques]

...
2. Also, given this new finding, ...
...

I don't understand... How could this possibly be a "new finding" on October 31 when you said four weeks ago that you just received the "full report"?

... I was able to get the full report and have updated my signature...

Also, you claim that you updated your signature, but your current signature does not contain any of this information on MSI status, or KRAS/BRAF mutations.

This doesn't make any sense to me. Can you explain? What was the date of the specimen they used for these biomarker tests, and what was the date when you actually received this "new finding"?

Thank you.

Out-of-date signature:

DH, 56, Sigmoid & rectum
Adenocarcinoma 2cm
 G2: Moderately differentiated
T3N2aM0
Stage IIIb
LN 6/22
5/19 Baseline CEA value - 18.9
Lymphovascular invasion (LVI): present
Perineural invasion (PNI): not identified
Surgical margins: proximal -negative; distal - negative 1.5cm; circumferential - negative 1mm)
MSI status: Waiting‬
Lynch status: ?
KRAS/BRAF: ?
Open Restorative Proctectomy, J-Pouch Coloanal Anastomosis, Loop Ileo w/Appendectomy
Neo-adjuvant Xeloda/radiation
Adjuvant Chemo: to begin 11/19