ANDRETEXAS wrote:All I can state is that a friend of mine with rectal cancer was on Lonsurf and tolerated it very well without many terrible side effects. I was only on FOLFOX, so can't give you any personal experiences. She was on it for six or so months and was switched to something else that I cannot recall. Sorry I can't tell you more. Andre
Rock_Robster wrote:Hi amarie,
I’m sorry I don’t know a lot about Lonsurf, however have you investigated Stivarga (Regorafenib) with your oncologist? There is some interesting research underway at the moment using lower doses to get a response with fewer side effects (ReDOS), and also trials combining this with immunotherapy in MSS patients (REGONIVO) that may apply to you.
Best of luck,
Rob
Amarie123 wrote:Rock_Robster wrote:Hi amarie,
I’m sorry I don’t know a lot about Lonsurf, however have you investigated Stivarga (Regorafenib) with your oncologist? There is some interesting research underway at the moment using lower doses to get a response with fewer side effects (ReDOS), and also trials combining this with immunotherapy in MSS patients (REGONIVO) that may apply to you.
Best of luck,
Rob
Hi Rob,
I have read about Stiverga and it seems to be similar to Lonsurf. If I don’t have success with this I will ask my oncologist about it. Unfortunately I’m not a candidate for immunotherapy but the chemo pills are and option. Thank you for the suggestion.
boxhill wrote:Not terribly helpful, unfortunately, but a KRAS mutation does not disqualify you from immunotherapy, at least not from Keytruda. I would guess you are MSS, which would be the problem.
Sorry, I don't know anything much about Lonsurf or Stivarga, other than that my onc mentioned them as something we might try if I didn't respond to Keytruda. (Folfox didn't work for me, and my KRAS mutation precludes Erbitux and Vectibix, just as yours probably does.)
I do know that there is some research out there concentrating on KRAS mutations, and there are trials. I hope the one you were just on worked for you.
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