Butt wrote:I have dozens on tiny mets several mm. All over my lungs. SERB and Vats not an option because of their number. I am on chemo. It appears after 8 sessions 4 slightly increased in size and the rest are there, so chemo is not erasing them.I am MSS. I hate chemo for life prognosis. I sent DR. Drewes In Coswig Germany but he said he wouldn’t take me because he would afraid to miss some tiny ones.Any doctors, hospitals who work with such situation besides chemo for life until it stops working? Butt.
This is pretty much my only option as I have a KRAS mutation and therefore won’t be on immunotherapy.
boxhill wrote:This is pretty much my only option as I have a KRAS mutation and therefore won’t be on immunotherapy.
A KRAS mutation does not have anything to do with suitability for immunotherapy. I have a KRAS mutation and I am on immunotherapy.
A KRAS mutation precludes EGFR pathway drugs like Erbitux and Vectibix.
https://www.nature.com/articles/nrclinonc.2009.111
Amarie123 wrote:boxhill wrote:This is pretty much my only option as I have a KRAS mutation and therefore won’t be on immunotherapy.
A KRAS mutation does not have anything to do with suitability for immunotherapy. I have a KRAS mutation and I am on immunotherapy.
A KRAS mutation precludes EGFR pathway drugs like Erbitux and Vectibix.
https://www.nature.com/articles/nrclinonc.2009.111
My genetic testing report and my onc said the only immunotherapy medication I would respond to is Avastin. Maybe there’s something else with the KRAS mutation that I forgot, but that’s my situation right now.
Rock_Robster wrote:boxhill wrote:
A KRAS mutation does not have anything to do with suitability for immunotherapy. I have a KRAS mutation and I am on immunotherapy.
A KRAS mutation precludes EGFR pathway drugs like Erbitux and Vectibix.
https://www.nature.com/articles/nrclinonc.2009.111
My genetic testing report and my onc said the only immunotherapy medication I would respond to is Avastin. Maybe there’s something else with the KRAS mutation that I forgot, but that’s my situation right now.
Amarie123 wrote:Rock_Robster wrote:boxhill wrote:
A KRAS mutation does not have anything to do with suitability for immunotherapy. I have a KRAS mutation and I am on immunotherapy.
A KRAS mutation precludes EGFR pathway drugs like Erbitux and Vectibix.
https://www.nature.com/articles/nrclinonc.2009.111
My genetic testing report and my onc said the only immunotherapy medication I would respond to is Avastin. Maybe there’s something else with the KRAS mutation that I forgot, but that’s my situation right now.
Hi amarie, it is likely your microsatellite stability status on the report (presume MSS) which precludes you from the currently-approved immunotherapies (PD1 inhibitors), rather than the KRAS mutation. However you may still respond to a PD1 inhibitor if you have a high tumour mutation burden (TMB), or if it’s combined with another drug. There are also lots of immunotherapies beyond PD1 inhibitors presently available through trials. Personally I would be very interested in my TMB status and accessing immuno options for MSS patients, esp. given 5FU-based therapy is off the table.
Also Avastin isn’t usually considered an immunotherapy, rather it’s a targeted therapy known as a monoclonal antibody.
Best of luck,
Rob
Rock_Robster wrote:Amarie123 wrote:
My genetic testing report and my onc said the only immunotherapy medication I would respond to is Avastin. Maybe there’s something else with the KRAS mutation that I forgot, but that’s my situation right now.
Hi amarie, it is likely your microsatellite stability status on the report (presume MSS) which precludes you from the currently-approved immunotherapies (PD1 inhibitors), rather than the KRAS mutation. However you may still respond to a PD1 inhibitor if you have a high tumour mutation burden (TMB), or if it’s combined with another drug. There are also lots of immunotherapies beyond PD1 inhibitors presently available through trials. Personally I would be very interested in my TMB status and accessing immuno options for MSS patients, esp. given 5FU-based therapy is off the table.
Also Avastin isn’t usually considered an immunotherapy, rather it’s a targeted therapy known as a monoclonal antibody.
Best of luck,
Rob
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