Partial intestinal obstruction and increasing ascites

[Delmundoc]

Hello all,
My husband was admitted last night at City of Hope for partial intestinal obstruction with increasing ascites. this is his 2nd recurrence after failing folfiri and irenotican. He’s been on erbitux and irenotican since February. looks like he’s not responding to this regimen. What else do you think he can use? Anybody with similar history?
Thank you so much.
Connie

[Rock_Robster]

Hi Connie, sorry it may be a silly question but has he been exposed to oxaliplatin (eg via FOLFOX) before? This is a common first-line, along with FOLFIRI. Depending on some other factors an anti-VEGF drug such as Avastin (bevacizumab) may also often be considered.

Given he has been on Erbitux I presume he doesn’t have a RAS mutation... do you happen to know his MSS status and/or tumour mutation burden (TMB)? This would be important for potential immunotherapy routes (eg Keytruda/Opdivo).

The folk at CoH should be all over this stuff though anyway. Best wishes to you both.

Rob