AmyG wrote:I found out today that I'm wild for everything. KRAS BRAF and two others, as well as low probability for MSI-H.
I'm trying to educate myself and see my oncologist again before starting any treatment. I'm assuming that's what I wanted? No mutations?
In other news, CEA is up to 71. Was 24 in December.
AmyG wrote:I found out today that I'm wild for everything. KRAS BRAF and two others, as well as low probability for MSI-H.
I'm trying to educate myself and see my oncologist again before starting any treatment. I'm assuming that's what I wanted? No mutations?
In other news, CEA is up to 71. Was 24 in December.
AmyG wrote:Hey thanks! Not overly upset about my CEA rising. I mean, I have a pretty large liver met, so it makes plenty of sense that it's going up. I know being pregnant can also impact it as well. Same for my liver function values. Those were raised, but well within the normal limits of someone in their third trimester.
I'll see my oncologist again 4/3. I should be getting a better plan of action then. Everything is still up in the air with exactly what is happening when, but should tentatively get a port, chest, abdomen and pelvic CT as well as another MRI of my liver before any chemo starts. Folfox and Avastin for 4 cycles, then 2 cycles without Avastin, rescan, liver resection, then 6 more cycles. Maintenance chemo after all that, I think she said for 6 months?
I'm ready to get this show on the road so I can be cancer free.
boxhill wrote:I got the KRAS, BRAF, and dMMR results with my initial pathology report.
Full genetic testing was done later.
ginabeewell wrote:
If you are wild type, why are they choosing to use Avastin versus an EGFR inhibitor like Vectibix which shows better results for patients like you? Vectibix is no picnic for side effects but it has really been effective in my case so curious whether you've discussed.
AmyG wrote:
I honestly have no idea, that's just what was discussed Wednesday. When I see her next month, I will be asking her a laundry list of questions! Vectibix is the one that usually causes the rash, right?
ginabeewell wrote:AmyG wrote:
My onc has explained that EGFR inhibitors do not work on non-wild-type, but that they tend to perform better than Avastin for wild type.
Pyro70 wrote:Amy sorry to butt in here. Centuximab (EGFR) is now only recommended in first line if you have a left sided tumor. Your signature didn’t say the location of your tumor but that may be why they will start with VEGF (Avastin). Even for left sided, in the US it’s not uncommon to use Avastin first and save centuximab for second line. In EU there is a strong preference for centuximab first. I think either way is fine.
My bigger question based off your signature would be why are they not jumping straight to liver resection? Is it inoperable? If it is currently inoperable i would think to use FOLFOXFIRI to try and downstage the tumor and hopefully make it resectable.
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