Dear O Stoma Mia,
I have been reading about ’possible biopsi and ablation/surgery’.
Suddenly I remembered the feeling that I wished I had known about Cimetidine when DH had his surgeries (did not know/understand until after DH’s surgeries in 2016).
From http://coloncancersupport.colonclub.com ... ry#p447809
Maia: ”Those going for surgery (or even for biopsies) might benefit, if your doctors do not object, by taking cimetidine some days (or a week) before and after surgery (specially before). There are several articles, over the years, that state that cimetidine may help to prevent seeding and, therefore, recurrence.
Cimetidine is Tagamet, the anti-acid, over-the-counter. It is a histamine H₂ receptor antagonist that inhibits stomach acid production but happens to have this effect also.”
(She has references to studies)
In that same thread you OSM post about interactions...http://coloncancersupport.colonclub.com ... 81#p384289
I used your link posted there now and checked DH’s prescribed meds.
Metformine BGR 850mg
”cimetidine will increase the level or effect of metformin by basic (cationic) drug competition for renal tubular clearance. Use Caution/Monitor.”
”cimetidine will increase the level or effect of silodosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.”
Sadly I can not find info about perindopril)
”cimetidine will increase the level or effect of amlodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.”
So... thinking out loud.. should I order Cimetidine? and try to contact/ask our Onc before the appointment? (worried she will say no). If the PET is not good I presume the biopsi/ablation will take place soon after our appointment with the Onc so I guess then it will be too late to start Cimetidine
If you O Stoma Mia or anyone else would like to comment on this - I will be very grateful.
DH @ 65 DX 4/11/16 CC recto-sigmoid junction
Adenocarcenoma 35x15x9mm G3(biopsi) G1(surgical)
Mets 3 Liver resectable
T4aN1bM1a IVa 2/9 LN
MSS, KRAS-mut G13DCEA
: 5/18 2.5 78 8/17 1.4 48 2/14/17 1.8 29
4 Folfox 6/15-7/30 (b4 liver surgery) 8 after
CT: 8/8 no change 3/27/17 NED->Jan-19 mets to lung NED again Oct-19
Steroid induced hyperglycemia dx after 3chemoSurgeries 2016
: 3/18 Emergency colostomy
5/23 Primary+gallbl+stoma reversal+port 9/1 Liver metsRFA 2019
: Feb & Oct lung mets