Stewsbetty wrote:angielada wrote:Thanks all...and good luck!
They are testing his MSI. He does have Kras mutation.
For those currently on Keytruda:
How long have u been on it?
Did they give u a length of time you will do it for?
How often and how long are treatments?
Do you still do regular chemo with it?
And, how bad ate side effects compared to Folfiri/Folfix?
Thank you sooo much for your replies! I really hope you are doing well!
Hi Angie,
I just had my 3rd treatment of Keytruda. I was not given any end date for it. Because it is a newer thing there isn’t much data on treatment lengths. I have a dose every three weeks. The standard dose is 200mg. I think the treatment length probably varies with each infusion centre. The drug running takes about 45 minutes. But it is often more than a couple hours. Depending on how easily my port is accessed or whether the pharmacy gets the drugs over quickly, etc. I am having the Keytruda on its own, no chemo. The first cycle I was in so much pain and was extremely fatigued. The next two I have been pretty much myself. Maybe a tad more tired on the infusion week. This is way better than my reaction to folfox and folfiri. Both of those put me in the hospital at least once!
Beth
henry123 wrote:Hello
Have been declared NED with clear CT and normal CEA Levels of 1.5 .
To continue with Opdivo for now.
May stop after 6 months or a year.
Oncologist doesn't want to risk a relapse and taking conservative approach.
Will update in detail later.
henry123 wrote:Hello
Have been declared NED with clear CT and normal CEA Levels of 1.5 .
To continue with Opdivo for now.
May stop after 6 months or a year.
Oncologist doesn't want to risk a relapse and taking conservative approach.
Will update in detail later.
Heather wrote:Stewsbetty wrote:angielada wrote:Thanks all...and good luck!
They are testing his MSI. He does have Kras mutation.
For those currently on Keytruda:
How long have u been on it?
Did they give u a length of time you will do it for?
How often and how long are treatments?
Do you still do regular chemo with it?
And, how bad ate side effects compared to Folfiri/Folfix?
Thank you sooo much for your replies! I really hope you are doing well!
Hi Angie,
I just had my 3rd treatment of Keytruda. I was not given any end date for it. Because it is a newer thing there isn’t much data on treatment lengths. I have a dose every three weeks. The standard dose is 200mg. I think the treatment length probably varies with each infusion centre. The drug running takes about 45 minutes. But it is often more than a couple hours. Depending on how easily my port is accessed or whether the pharmacy gets the drugs over quickly, etc. I am having the Keytruda on its own, no chemo. The first cycle I was in so much pain and was extremely fatigued. The next two I have been pretty much myself. Maybe a tad more tired on the infusion week. This is way better than my reaction to folfox and folfiri. Both of those put me in the hospital at least once!
Beth
Hi Betty,
My mom was diagnosed with stage 4 CRC Easter 2017. She had emergency surgery to remove the blosckage the same day, followed by folfiri, which we found out failed. We are trying to figure out how to get keytruda or opdiva and are very interested in learning more about your experience. We found out yesterday that my moms tumor is KRAS and she has the dMMR gene. She is also a BC resident. We applied for the compassionate care program through MERCK but were denied. Would you be willing to chat via email or phone? I hope you’re doing well and the treatments are working for you.
henry123 wrote:Hello
Have been declared NED with clear CT and normal CEA Levels of 1.5 .
To continue with Opdivo for now.
May stop after 6 months or a year.
Oncologist doesn't want to risk a relapse and taking conservative approach.
Will update in detail later.
Stewsbetty wrote:henry123 wrote:Hello
Have been declared NED with clear CT and normal CEA Levels of 1.5 .
To continue with Opdivo for now.
May stop after 6 months or a year.
Oncologist doesn't want to risk a relapse and taking conservative approach.
Will update in detail later.
Yea! Yea! Yea! So excited to hear this. I hope to join you in the future!
Beth
henry123 wrote:Any update on approval for immunotherapy drugs for msi-high CRC in Canada ?
veckon wrote:Fatigue is the most persistent. It started out as just standard fatigue, but has since progressed to what can only be described as narcoleptic. The last two weeks I have seen a large increase in bleeding during loose bowel movements, which have become frequent enough to keep me from sleeping. I was hospitalized for slight anemia a few days ago because of this, but other than that my blood work actually looks good. I am at Sloan Kettering now actually waiting to be examined by my colorectal surgeon in greater detail.
henry123 wrote:veckon wrote:Fatigue is the most persistent. It started out as just standard fatigue, but has since progressed to what can only be described as narcoleptic. The last two weeks I have seen a large increase in bleeding during loose bowel movements, which have become frequent enough to keep me from sleeping. I was hospitalized for slight anemia a few days ago because of this, but other than that my blood work actually looks good. I am at Sloan Kettering now actually waiting to be examined by my colorectal surgeon in greater detail.
Veckon, Big Rob , what's going on? Haven't heard from you guys in a while
veckon wrote:henry123 wrote:veckon wrote:Fatigue is the most persistent. It started out as just standard fatigue, but has since progressed to what can only be described as narcoleptic. The last two weeks I have seen a large increase in bleeding during loose bowel movements, which have become frequent enough to keep me from sleeping. I was hospitalized for slight anemia a few days ago because of this, but other than that my blood work actually looks good. I am at Sloan Kettering now actually waiting to be examined by my colorectal surgeon in greater detail.
Veckon, Big Rob , what's going on? Haven't heard from you guys in a while
Still alive and fighting. Continuing pembrolizumab and have not had a recurrence of colitis since resuming treatment. My treatment related fatigue has improved moderately in the last few cycles, but insomnia and stress have conspired to still deprive me of sleep. Overall on a positive trajectory.
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