Cause of colon cancer discovered

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rockhound
Posts: 106
Joined: Fri Jul 14, 2017 5:00 pm

Re: Cause of colon cancer discovered

Postby rockhound » Tue Feb 13, 2018 11:07 am

Rikimaroo wrote:We are just unlucky, cries....No more casinos for me unlucky there too. LOL


I won $15 playing blackjack once, but more than made up for that via losses...that is the truth about casinos!!
42 yr old male
Diagnosed December 2016, age 41
Stage 1/IIA rectal cancer - T2/3N0M0 via MRI (MRI indicates stage 1; onc/surgeon = stage 2a)
Lynch syndrome, MSH6 mutation, MSI
2 to 3/2017 Xeloda + Radiation
5/10/17 - Robotic LAR with temp. loop illeostomy, 0/20 lymph nodes
6 to 7/2017 - Six cycles Folfox @ full strength
9/20/17 - Ileostomy takedown
10/17 - CT, NED
1/18 - 5mm polyp removed during colonoscopy
5/18 - CT, NED

mpbser
Posts: 390
Joined: Wed Apr 19, 2017 11:52 am

Re: Cause of colon cancer discovered

Postby mpbser » Tue Feb 13, 2018 3:40 pm

My husband drank at least 2 liters of diet soda for many many years before his diagnosis. His consumption dramatically reduced afterwards.

I credit that partially to my reading of the section on aspartame in Ty Bollinger's book Cancer: Step Outside the Box to him when he was in the hospital having his heart catheterization (sp?) angiogram for clearance for surgery last year. I cringe when he buys it every now and then, but THANK GOD it is not very often.
Wife 4/17 Dx age 45
5/17 - Lap left hemi
Adenocarcinoma
5 x 4 x 1 cm
low grade
T3 N2b M1a
Stage IV A
lymph nodes: 9 of 54
8/17 Sub-total colectomy
2nd tumor 5.5 cm T1 N0
CEA: 1.4, 2.1, 1.5, 1.9, 1.9, 2.1, 2.1, 2.4, 1.7, 2.0
MSS/MSI-L
Lynch no; KRAS wild
Immunohistochemsistry: Normal MLH1, MSH2, MSH6, and PMS2
Tumor DNA variants: MTOR, APC, TP53
Liver left hepatectomy seg 4 1/31/18

heiders33
Posts: 221
Joined: Sat Nov 04, 2017 11:08 am

Re: Cause of colon cancer discovered

Postby heiders33 » Tue Feb 13, 2018 7:49 pm

I never drank or drink diet soda, but I'm sure there were environmental and food factors that played into my diagnosis, combined with an unlucky random mutation. I mentioned on a previous thread that I have lived with one of my triplet sisters for the last decade, and we have essentially had a similar diet, etc. Yet her colon is clean as a whistle.
36 year-old female
May 2017: Dx rectal cancer at T3N2M0
MSS, no genetic mutations
June-July 2017: 28 days of chemo/radiation
September 2017: laparoscopic LAR surgery with loop ileostomy
October 2017 - February 2018: six rounds of mop-up XELOX
March 12, 2018: reversal
April 16, 2018: CEA 2.1, all blood counts within normal ranges
May 2018: CT scan showed liver spot, MRI scheduled

User avatar
Shana
Posts: 371
Joined: Sun Jul 30, 2017 9:45 pm
Location: Sonoma, CA

Re: Cause of colon cancer discovered

Postby Shana » Wed Feb 14, 2018 2:34 pm

heiders33 wrote:I never drank or drink diet soda, but I'm sure there were environmental and food factors that played into my diagnosis, combined with an unlucky random mutation. I mentioned on a previous thread that I have lived with one of my triplet sisters for the last decade, and we have essentially had a similar diet, etc. Yet her colon is clean as a whistle.


Wow that's an interesting factor having a triplet sister and living together and sharing same diet. Makes one wonder what kind of environmental exposures play into all of this as well as random mutation as you said.

Wishing you the best as you continue your treatment :)

Shana
DX - 12/16
MSS - KRAS wild
Well-differentiated adenocarcinoma at splenic flexure
Stage IV CC with liver mets
5FU - Failed twice - 1/17 and 3/17
Irinotecan + Cetuximab: 8/17
CEA 12/17 - 38.7! 1/18 - 33! 2/18-36.5 3/18-39.8 4/18- 54 (ugh) 5/11/18 -78 :( 5/25/18-63!!!!
CT-Scan 5/18 -mixed -some progression and some shrinkage, possibly pseudo
Irinotecan increased to 200mg on 5/7/18 in response to increased CEA and it's working as of 5/25!

mpbser
Posts: 390
Joined: Wed Apr 19, 2017 11:52 am

Re: Cause of colon cancer discovered

Postby mpbser » Wed Feb 14, 2018 4:43 pm

heiders, You and your sister would make a very good case study! Studies on twins/etc yield valuable results.
Wife 4/17 Dx age 45
5/17 - Lap left hemi
Adenocarcinoma
5 x 4 x 1 cm
low grade
T3 N2b M1a
Stage IV A
lymph nodes: 9 of 54
8/17 Sub-total colectomy
2nd tumor 5.5 cm T1 N0
CEA: 1.4, 2.1, 1.5, 1.9, 1.9, 2.1, 2.1, 2.4, 1.7, 2.0
MSS/MSI-L
Lynch no; KRAS wild
Immunohistochemsistry: Normal MLH1, MSH2, MSH6, and PMS2
Tumor DNA variants: MTOR, APC, TP53
Liver left hepatectomy seg 4 1/31/18

User avatar
Shana
Posts: 371
Joined: Sun Jul 30, 2017 9:45 pm
Location: Sonoma, CA

Re: Cause of colon cancer discovered

Postby Shana » Wed Feb 14, 2018 5:40 pm

mpbser wrote:heiders, You and your sister would make a very good case study! Studies on twins/etc yield valuable results.


I agree! Identical or fraternal triplets?
My daughter went to school with triplets, two were identical and the third was fraternal, all boys.
DX - 12/16
MSS - KRAS wild
Well-differentiated adenocarcinoma at splenic flexure
Stage IV CC with liver mets
5FU - Failed twice - 1/17 and 3/17
Irinotecan + Cetuximab: 8/17
CEA 12/17 - 38.7! 1/18 - 33! 2/18-36.5 3/18-39.8 4/18- 54 (ugh) 5/11/18 -78 :( 5/25/18-63!!!!
CT-Scan 5/18 -mixed -some progression and some shrinkage, possibly pseudo
Irinotecan increased to 200mg on 5/7/18 in response to increased CEA and it's working as of 5/25!

heiders33
Posts: 221
Joined: Sat Nov 04, 2017 11:08 am

Re: Cause of colon cancer discovered

Postby heiders33 » Wed Feb 14, 2018 5:53 pm

We are all three identical sisters. I should look into case studies.
36 year-old female
May 2017: Dx rectal cancer at T3N2M0
MSS, no genetic mutations
June-July 2017: 28 days of chemo/radiation
September 2017: laparoscopic LAR surgery with loop ileostomy
October 2017 - February 2018: six rounds of mop-up XELOX
March 12, 2018: reversal
April 16, 2018: CEA 2.1, all blood counts within normal ranges
May 2018: CT scan showed liver spot, MRI scheduled

AlexMichelle
Posts: 42
Joined: Sat Oct 28, 2017 11:54 am
Location: California

Re: Cause of colon cancer discovered

Postby AlexMichelle » Wed Feb 14, 2018 8:27 pm

Yes, I'm sure a study with you triplets would be enlightening. How interesting. Yes, I do agree the Diet Coke consumption could not have helped, and may have contributed, and the only reason I stopped cold turkey a few years ago was because my daughters kept begging me to stop because they were convinced it caused cancer. I really loved to drink them and didn't think they would cause harm, but stopped for them. Now I use Stevia in moderation and hope later we don't find out it was harmful. I thought I could get cancer, but colon cancer was the last on the list with my high fiber vegetarian lifestyle.
F 9/14/17 blood, 10/05/17 endoscopy/colonoscopy 4.5 cm tumor lower colon/upper rectum/left side -11/09/17 open Rectosigmoid Colon Resection remove invasive adenocarcinoma, moderately diff marg clear.15 lymph nodes neg malignancy. benign liver w/fibrous nodule- rectum at 15cm Tumor location: above peritoneal reflection 4.2 x 2.7 cm Tumor inv muscularis closest 1.5 cm. pT2pNO Stage 1. No Lynch


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