Cause of colon cancer discovered

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Chickspeed
Posts: 43
Joined: Sat Jun 17, 2017 5:16 am

Cause of colon cancer discovered

Postby Chickspeed » Fri Feb 09, 2018 5:05 pm

12/15/2016 Mod Diff tumour 5-6 cm 10-12 cm fr AV T3 tumour cea 1.4
12/29/2016 CT no spread ln normal
1/19/2017 MRI confirms mass and shows 3 enlarged LN (suspected to be infection draining)
3/6/2017 25 sessions chemoradiation
6/20/2017 LAR with temp loop ileo
7/10/2017 Path 20mm margins tumour 0.1 CM with microscopic invasion of submucosa
aug-dec 2017 6 rnds xeloda
1/9/2018 CT all clear
1/18/2018 Colonoscopy clear
3/27/2018 ileo reversal
CEA continues to be normal

NHMike
Posts: 2555
Joined: Fri Jul 21, 2017 3:43 am

Re: Cause of colon cancer discovered

Postby NHMike » Fri Feb 09, 2018 5:32 pm

Absolutely amazing science.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8, 2/12 1.2
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal
2/19: Clean CT

mpbser
Posts: 953
Joined: Wed Apr 19, 2017 11:52 am

Re: Cause of colon cancer discovered

Postby mpbser » Sun Feb 11, 2018 7:00 am

This makes sense since it's been known for a while that a healthy gut microbiome prevents cancer.
Wife 4/17 Dx age 45
5/17 LAR
Adenocarcinoma
low grade
1st primary T3 N2b M1a
Stage IVA
8/17 Sub-total colectomy
2nd primary 5.5 cm T1 N0
9 of 96 nodes
CEA: < 2.9
MSS
Lynch no; KRAS wild
Immunohistochemsistry Normal
Fall 2017 FOLFOX shrank the 1 met in liver
1/18 Liver left hepatectomy seg 4
5/18 CT clear
12/18 MRI 1 liver met
3/7/19 Resection & HAI
4/1/19 Folfiri & FUDR
5/13/19 HAI pump catheter dislodge, nearly bled to death
6-7 '19 5FU 4 cycles
NED

Utwo
Posts: 285
Joined: Mon May 23, 2016 10:14 am
Location: T.O.

Re: Cause of colon cancer discovered

Postby Utwo » Sun Feb 11, 2018 10:41 am

They have a nice theory. However we need more work to prove it.

Anyway, you need to remember that "correlation doesn't mean causation".
58 yo male at diagnosis: T1bN0M0, 0/15 nodes, low grade/moderately differentiated adenocarcinoma
03/2016 colonoscopy: 2 small polyps removed in left colon; CEA = 1.3
04/2016 colonoscopy: caecum sessile 3.5 cm polyp piecemeal removed with kind of clear margins
05/2016 "prophylactic" laparoscopic right hemicolectomy - bleeding, leak, infection
06/2017 CT scan, colonoscopy OK; CEA = 1.6
A lot of funny stuff discovered by CT scans in liver, kidney, lungs, arteries, gallbladder, lymph node, pancreas

NHMike
Posts: 2555
Joined: Fri Jul 21, 2017 3:43 am

Re: Cause of colon cancer discovered

Postby NHMike » Sun Feb 11, 2018 10:46 am

Reminds me of the discovery of H. Pylori.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8, 2/12 1.2
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal
2/19: Clean CT

User avatar
CRguy
Posts: 10473
Joined: Sun Feb 10, 2008 6:00 pm

Re: Cause of colon cancer discovered

Postby CRguy » Sun Feb 11, 2018 11:14 pm

NOT trying to be the wet rag here,
thrown on the embers of new hope ...... BUTT

the reference is from a 2015 study with a theory ... yada yada yada
= I am not buying in right now and .... I really don't follow anything on MSN channels

IF something shows up in the reviewed science journal feeds I may get excited
OR , I may not ... BECAUSE
both these "bacteria" are normal commensal inhabitants of human GITs

Utwo already posted : "correlation doesn't mean causation"

WORD !

I will always keep an open mind ...
just NOT so open my brain falls out ! :shock:

NOT trying to be obstreperous
just being me ... BUTT always enjoy the chance to exchange opinions and views with homies here

Cheers all
CR

being grumpy :twisted:
Caregiver x 4
Stage IV A rectal cancer/lung met
17 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

User avatar
Atoq
Posts: 412
Joined: Wed Oct 25, 2017 9:31 am

Re: Cause of colon cancer discovered

Postby Atoq » Mon Feb 12, 2018 7:14 am

It is very complicated to analyse this type of data, I am myself trying to analyse a dataset on intestinal microbiome in lundehund. Microbes in the guts affect each other and are affected by diet, age, immunsystem, genetics. Who is affecting who? Microbiome is also modulating immune response and affecting our brain. There are even papers showing how microbiome correlates with aging. It is indeed a promising field :D

Best

Claudia
1972, 2 kids
Dx rectal cancer 10.2017
T3N2aMX (met left lung 8 mm)
Lynch neg
CEA 1.8
Neoadjuvant chemoradio Xeloda + 25x2 Gy
05.12.17 laparotomic surg. for blockage, colostomy
25.01.18 laparotomic lar, hysterectomy, ileostomy
05.03.18 core needle lung biopsy
07.05.18 CAT scan, lung met 11 mm
04.06.18 ileo reversal
26.06.18 wedge VATS
24.08.18, 31.02.19 CAT scan
12.09.18, 06.02.19 scope, CEA 1.6
19.11.18 scope
20.08.19 CAT, eco
13.09.19 scope, CEA 1.2
18.03.20 CAT, eco, scope, NED
29.11.20 CAT, NED
2023 NED

Rikimaroo
Posts: 436
Joined: Tue Dec 20, 2016 8:48 pm
Location: Florida

Re: Cause of colon cancer discovered

Postby Rikimaroo » Mon Feb 12, 2018 10:36 am

For Colo rectal Cancer, I think its mainly what you eat and how your lifestyle is in regarding movement. If you sit all day and don't get up to allow blood circulation, or eat a lot of red meat, and drink a lot of alcohol I think this contributes more heavily then this study.

Most docs I know have said high consumption, especially grilling open fire of meats increases the carcinogenic activities in the meats. Plus sitting down all day doesn't help either LOL...
RC T3N1M0 12/16
MSS - NRAS Mutation
Chemo Rad, CCR - W&W 5/2017
Recurrence 11/2017
CT Scan 11/2017 Liver Met 5.5cm Stable, Stage IV
LAR/Liver Resect 4/2018
Reversal 10/18
CEA highest 500, lowest .8 throughout process, waiting for latest
Recurrence left vesical/pelvic sidewall - 10/7/2019 resect perm bag,
CEA rise Feb/May 3.7, 8.8, 30, Recurrence in Pelvic
CEA 40 right now, but was 57, so folfiri to beat it back down.
Lots of chemo for the past 4 years.

NHMike
Posts: 2555
Joined: Fri Jul 21, 2017 3:43 am

Re: Cause of colon cancer discovered

Postby NHMike » Mon Feb 12, 2018 11:38 am

Rikimaroo wrote:For Colo rectal Cancer, I think its mainly what you eat and how your lifestyle is in regarding movement. If you sit all day and don't get up to allow blood circulation, or eat a lot of red meat, and drink a lot of alcohol I think this contributes more heavily then this study.

Most docs I know have said high consumption, especially grilling open fire of meats increases the carcinogenic activities in the meats. Plus sitting down all day doesn't help either LOL...


I know people that are highly active that have had CRC and know those that are sedentary that have it.

Video of me playing tennis for 50 minutes on the next to last day of Chemo and Radiation:

https://www.youtube.com/watch?v=R_ipaq4HTk0&t=1284s

I ran over 40 miles the week before I was diagnosed, and, except for the tumor, felt fantastic. I do sit when I work but I get up a lot for quick trips to the gym for little workouts. The Adjuvant chemo has killed a lot of that but I'm eager to get back to getting in shape, running, playing tennis, doing weights, yoga and pilates.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8, 2/12 1.2
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal
2/19: Clean CT

Rikimaroo
Posts: 436
Joined: Tue Dec 20, 2016 8:48 pm
Location: Florida

Re: Cause of colon cancer discovered

Postby Rikimaroo » Mon Feb 12, 2018 11:45 am

i agree with you NHmike. It can happen to anyone no matter. But they have linked colorectal cancer to mainly what you eat and your lifestyle. I mean cancer can happen to a perfectly healthy person. Do I hate that red meat is linked to it or alcohol or sedentary sure...but it is what it is.

NHMike let me ask you did you eat alot of deli meats, steak, sausage, hot dogs, bacon (pork)?
RC T3N1M0 12/16
MSS - NRAS Mutation
Chemo Rad, CCR - W&W 5/2017
Recurrence 11/2017
CT Scan 11/2017 Liver Met 5.5cm Stable, Stage IV
LAR/Liver Resect 4/2018
Reversal 10/18
CEA highest 500, lowest .8 throughout process, waiting for latest
Recurrence left vesical/pelvic sidewall - 10/7/2019 resect perm bag,
CEA rise Feb/May 3.7, 8.8, 30, Recurrence in Pelvic
CEA 40 right now, but was 57, so folfiri to beat it back down.
Lots of chemo for the past 4 years.

User avatar
Atoq
Posts: 412
Joined: Wed Oct 25, 2017 9:31 am

Re: Cause of colon cancer discovered

Postby Atoq » Mon Feb 12, 2018 12:17 pm

Anyway, by adding genetics, lifestyle and diet as factors you will only find an increase in probability to get colon cancer when you have a large statistical sample.

So from a single person it is very difficult to extrapolate.

One can be very active, eating healthy and skinny, but might just got a casual mutation (error in DNA duplication) that went undetected, or maybe ate too many veggies or fruit coming from polluted areas.

There are so many unknown factors that can be summarized as «bad luck». Of course meat, diary products and sugar are not helping.

Claudia
1972, 2 kids
Dx rectal cancer 10.2017
T3N2aMX (met left lung 8 mm)
Lynch neg
CEA 1.8
Neoadjuvant chemoradio Xeloda + 25x2 Gy
05.12.17 laparotomic surg. for blockage, colostomy
25.01.18 laparotomic lar, hysterectomy, ileostomy
05.03.18 core needle lung biopsy
07.05.18 CAT scan, lung met 11 mm
04.06.18 ileo reversal
26.06.18 wedge VATS
24.08.18, 31.02.19 CAT scan
12.09.18, 06.02.19 scope, CEA 1.6
19.11.18 scope
20.08.19 CAT, eco
13.09.19 scope, CEA 1.2
18.03.20 CAT, eco, scope, NED
29.11.20 CAT, NED
2023 NED

NHMike
Posts: 2555
Joined: Fri Jul 21, 2017 3:43 am

Re: Cause of colon cancer discovered

Postby NHMike » Mon Feb 12, 2018 12:27 pm

Rikimaroo wrote:i agree with you NHmike. It can happen to anyone no matter. But they have linked colorectal cancer to mainly what you eat and your lifestyle. I mean cancer can happen to a perfectly healthy person. Do I hate that red meat is linked to it or alcohol or sedentary sure...but it is what it is.

NHMike let me ask you did you eat alot of deli meats, steak, sausage, hot dogs, bacon (pork)?


I do not eat pork or shellfish.

I had changed my diet 10 years ago to reduce red meat but not completely eliminate it.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8, 2/12 1.2
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal
2/19: Clean CT

NHMike
Posts: 2555
Joined: Fri Jul 21, 2017 3:43 am

Re: Cause of colon cancer discovered

Postby NHMike » Mon Feb 12, 2018 12:31 pm

Atoq wrote:Anyway, by adding genetics, lifestyle and diet as factors you will only find an increase in probability to get colon cancer when you have a large statistical sample.

So from a single person it is very difficult to extrapolate.

One can be very active, eating healthy and skinny, but might just got a casual mutation (error in DNA duplication) that went undetected, or maybe ate too many veggies or fruit coming from polluted areas.

There are so many unknown factors that can be summarized as «bad luck». Of course meat, diary products and sugar are not helping.

Claudia


I read an article indicating that your odds for cancer grow exponentially as you get older because all of the cell splits can result in wider and wider mutations. It's also possible to lose some of the mutation repair stuff over time. There's also Allele protection. I did some research into Alleles for the TIL stuff and found that we get six of these things and there are hundreds of different kinds and that the Alleles that you get protect you from various diseases. So you might be more prone to various illnesses depending on what Alleles you were coded from. Immunology is fascinating stuff.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8, 2/12 1.2
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal
2/19: Clean CT

Rikimaroo
Posts: 436
Joined: Tue Dec 20, 2016 8:48 pm
Location: Florida

Re: Cause of colon cancer discovered

Postby Rikimaroo » Mon Feb 12, 2018 12:37 pm

The statistics to get colorectal cancer at my age 39, is very low, I think like 2.4 percent I read somewhere. It is defintely some mutation or that one month in october of 2016 where I ate sausage every day cause we had like 40 left over from a bday party for my daughter. Who knows though really. I mean that year the the year before 2015 i ate alot of red meat and stuff, and sedentary lifestyle even though I am not fat.

You just never know, I mean I think I was still active enough to not get cancer, but I wonder all the time, why me and how the hell did this happen. I know people who eat way worse then me and big around the waistline and still no issues. I mean not sure what there old age will bring but always wonder you know guys.

We will keep the good fight, I just want to survive for my kids.
RC T3N1M0 12/16
MSS - NRAS Mutation
Chemo Rad, CCR - W&W 5/2017
Recurrence 11/2017
CT Scan 11/2017 Liver Met 5.5cm Stable, Stage IV
LAR/Liver Resect 4/2018
Reversal 10/18
CEA highest 500, lowest .8 throughout process, waiting for latest
Recurrence left vesical/pelvic sidewall - 10/7/2019 resect perm bag,
CEA rise Feb/May 3.7, 8.8, 30, Recurrence in Pelvic
CEA 40 right now, but was 57, so folfiri to beat it back down.
Lots of chemo for the past 4 years.

NHMike
Posts: 2555
Joined: Fri Jul 21, 2017 3:43 am

Re: Cause of colon cancer discovered

Postby NHMike » Mon Feb 12, 2018 12:44 pm

Rikimaroo wrote:The statistics to get colorectal cancer at my age 39, is very low, I think like 2.4 percent I read somewhere. It is defintely some mutation or that one month in october of 2016 where I ate sausage every day cause we had like 40 left over from a bday party for my daughter. Who knows though really. I mean that year the the year before 2015 i ate alot of red meat and stuff, and sedentary lifestyle even though I am not fat.

You just never know, I mean I think I was still active enough to not get cancer, but I wonder all the time, why me and how the hell did this happen. I know people who eat way worse then me and big around the waistline and still no issues. I mean not sure what there old age will bring but always wonder you know guys.

We will keep the good fight, I just want to survive for my kids.


I had the flu from about November 2016 to April 2017 and I attribute my cancer to that. Might have been weakened immune system, stomach bug that introduced something bad into my digestive system or the body just not being able to cope with work and illness at the same time. But that seems to be the most obvious trigger to me for me.
6/17: ER rectal bleeding; Colonoscopy
7/17: 3B rectal. T3N1bM0. 5.2 4.5 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6, 5 x 5
7/17-9/17: Xeloda radiation
7/5: CEA 2.7; 8/16: 1.9; 11/30: 0.6; 12/20 1.4; 1/10 1.8; 1/31 2.2; 2/28 2.6; 4/10 2.8; 5/1 2.8; 5/29 3.2; 7/13 4.5; 8/9 2.8, 2/12 1.2
MSS, KRAS G12D
10/17: 2.7 2.2 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 (-75%), 5 x 3 (-40%). 5.1 CM from AV
10/17: LAR, Temp Ileostomy, Path Complete Response
CapeOx (8) 12/17-6/18
7/18: Reversal, Port Removal
2/19: Clean CT


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