Hi - was just wondering if there are any BRAF mutation colon cancer patients on this forum. My husband is currently enrolled in the BEACON trial Phase III at Sloan Kettering. It has 3 arms to the trial - one is a control arm, one has two drugs used to target BRAF and MEK inhibitor, and another arm has the three drug combo used to target EGFR, BRAF and the MEK signaling pathway. He starts Tuesday Nov. 28th and was randomized to get the 3 drugs Encorafenab, Binimetinib, Cetux (spelling might be wrong, sorry). Dr. Rona Yaeger is heading it up. I will keep updating this line so people can see how it goes.
Would love to hear from anyone who has been dealing with this particular mutation, and what therapies are working for you. Standard chemo (FOLFOX) didn't help him, but we are very hopeful about this clinical trial he is on. They've come a long way with this, and the trial sounds like a game changer.
I hope all of you are well, and that your therapies are keeping your cancer in check. Doesn't seem like there are a lot of people with this mutation.
All The Best,
Mrs. Ziggy