Keytruda and dry mouth

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plastikos
Posts: 303
Joined: Wed Jan 14, 2015 6:09 am

Keytruda and dry mouth

Postby plastikos » Wed Sep 06, 2017 4:35 am

Anyone here on Keytruda experience extreme dryness of the mouth? Is this common? I just noticed it after my last dose. Eating anything dry (chips, biscuits, bread) is a task.
St. IV Colon CA @ 37, male, Kras wild, MSI-high (2014)
11/2014 Right Hemicolectomy + Liver Resection
12/2014 - 6/2015 FOLFOX + Cetuximab
10/2015 - Recurrence liver
Liver resection 10/2015
FOLFIRI 11/2015 - 5/2016
Recurrence liver, nodes 11/2016
Pembrolizumab started 12/2016 -> pseudoprogression(?) -> biliary obstruction -> biliary stenting
Chemo 4x: most mets inactive and smaller on PET-CT
March 2017 - Back on Pembrolizumab again
Sept 2017 - SIRT - > NED

veckon
Posts: 131
Joined: Thu Jul 27, 2017 7:44 am

Re: Keytruda and dry mouth

Postby veckon » Wed Sep 06, 2017 12:41 pm

plastikos wrote:Anyone here on Keytruda experience extreme dryness of the mouth? Is this common? I just noticed it after my last dose. Eating anything dry (chips, biscuits, bread) is a task.


Yes.
27 yo male
Metastatic rectal cancer diagnosed 12/16
Liver metastases and peritoneal carcinomatosis
Lynch syndrome, MSI-H
Failed liver resection 3/17
FOLFOX6 12/16 - 05/17
Keytruda 5/17 - present
@Memorial Sloan Kettering

User avatar
BeansMama
Posts: 959
Joined: Thu Jan 28, 2016 1:38 am
Location: North Carolina

Re: Keytruda and dry mouth

Postby BeansMama » Thu Sep 07, 2017 8:03 am

Definitely, I always have a drink with me.
41 yrs old
Tumor found 9/2015
Surgery 1 - 11/2015 LAR and colostomy
Surgery 2 - 11/2015 wound vac
Surgery 3 - 12/2015 revise resection, move colostomy
Mets to liver - tumor inoperable - one add'l met destroyed
Stage IVa (T3 N2a M1a)
Primary tumor 9 cm x 7.5 cm x 2 cm
Beginning Folfox 1/2016 - Failed
Beginning Folfiri and vectibix 8/2016 — Failed
Beginning Folfirinox + Avastin 11/2016 - Failed
Beginning Keytruda 1/2017
CEA drop from 345 to 7.3 after starting immunotherapy
Lynch positive 3/2016

plastikos
Posts: 303
Joined: Wed Jan 14, 2015 6:09 am

Re: Keytruda and dry mouth

Postby plastikos » Thu Sep 07, 2017 5:25 pm

Thank you for the replies.
St. IV Colon CA @ 37, male, Kras wild, MSI-high (2014)
11/2014 Right Hemicolectomy + Liver Resection
12/2014 - 6/2015 FOLFOX + Cetuximab
10/2015 - Recurrence liver
Liver resection 10/2015
FOLFIRI 11/2015 - 5/2016
Recurrence liver, nodes 11/2016
Pembrolizumab started 12/2016 -> pseudoprogression(?) -> biliary obstruction -> biliary stenting
Chemo 4x: most mets inactive and smaller on PET-CT
March 2017 - Back on Pembrolizumab again
Sept 2017 - SIRT - > NED

Stewsbetty
Posts: 129
Joined: Thu Jul 14, 2016 7:08 am

Re: Keytruda and dry mouth

Postby Stewsbetty » Mon Jan 01, 2018 3:23 am

Oh my goodness, the dry mouth is horrible! Thank goodness the medication is working for me. I drink way more water now which I guess is a benefit. I have had 5 cycles now and I am thinking the dry mouth gets worse toward the end? Not sure about this but that is how it seems to me. Just found this link as I was googling dry mouth. Has it gotten better for any of you?

Beth
42yo At diagnosis. Female in BC, Canada
Dx: CC ascending
Right Hemi colectomy 06/16 clear margins
Adenocarcinoma 6cm High Grade
pT3 pN2a Stage 3
10 out of 16 lymph involved
MSI-h, Kras mut, Braf wild
Finished chemo Feb. 2017
PET scan showing active area April 2017
July 2017 CT showing LN mass and spread to other LN
Stage 4
Aug 2017 failed Fofiri
Sept 2017 keytruda
Nov 2017 CT scans show significant shrinkage in tumours
Feb 2018 CT continued shrinkage
May 2018 CT shrinkage and stable spots

henry123
Posts: 126
Joined: Sun Oct 08, 2017 3:25 am

Re: Keytruda and dry mouth

Postby henry123 » Mon Jan 01, 2018 6:49 am

Yes .

Also very dry feet (not HFS), sneezing, runny nose and frequent BM. Applying regular moisturiser to feet .

I say to myself (visualise )with every BM, sneeze , phlegm that it is tumors being flushed out of my body. :idea:

PS : I am on Opdivo.
46yo M
5/16 lap AR 14/21 L nodes +ve
T4N2M1
7/16 Capox 9 cyc
9/16 cea 2
1/17 550
PET CT mets in lung & peri
iri+ avast fail
3/17 10577
msi-h Lynch
4/17 regro fail
5/17 cea 28800
5/17 CT inc in size of mes nodes , new onset of multi nodules in liver.
6/17 Opdivo start
7/17 26754
8/17 5623
9/17 497
10/17 52
11/17 12
CT all clear exc a nodule in Lung. liver normal
1/18 3.6
2/18 2.3
4/18 2.0
opdivo continue
Aspirin start
6/18 1.5 CT clear
8/18 1.3
NED
Vegan yoga juicing apricot


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